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Patricia Kane protocol
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The '''Patricia Kane protocol''' (PK protocol) is an experimental treatment for neurological disease involving intravenous infusion of [[phospholipid]]s and [[methylation cycle|methylation]] factors, along with dietary changes and supplements. It is based on the theory that in diseases that Kane classes as those of neurotoxicity (e.g., [[multiple sclerosis]], [[Parkinson's disease]], [[chronic fatigue syndrome]]), toxins destabilize cell membranes leading to dysfunctions in cell signaling and [[homeostasis]] and [[neurodegeneration]]. Patricia Kane does not have a doctorate from an accredited university.<ref>{{Cite web|title=Autism treatment: Science hijacked to support alternative therapies|url=https://www.chicagotribune.com/lifestyles/health/chi-autism-science-nov23-story.html|website=Chicago Tribune|access-date=2023-04-17}}</ref>. Ms. Kane has a history of making unsubstantiated claims, such as disputing the ALS diagnosis of a patient who later died of ALS and was later dismissed from Haverford Wellness Clinic partly in response to investigations of this case.<ref>{{Cite web|title=I-Team Follow-Up: False Hope - cbs3.com|url=https://web.archive.org/web/20090307114535/http://cbs3.com/investigations/i.team.investigation.2.814584.html|website=web.archive.org|date=2009-03-07|access-date=2023-04-17}}</ref>) ==Theory== She seeks to correct deficiencies of [[Omega 6 fatty acid |omega 6]] and [[arachidonic acid]] in cell membranes and correct the over-expression of [[very long chain fatty acid]]s. ==Protocol== The protocol is individualized but involves several key components: intravenous infusion of [[phosphatidylcholine]] and [[sodium phenylbutyrate]], pushes of [[glutathione]] and [[folinic acid]] (leucovorin), [[methylcobalamin]] injections, and increased intake of [[essential fatty acid]]s. [[Patricia Kane]] recommends elimination of all processed foods, regular intake of pastured [[egg]]s, and a "cell membrane stabilizing drink" consisting of liquid phosphatidylcholine, [[evening primrose oil]], [[whey]] protein, and a blend of [[safflower oil]] and [[flaxseed oil]] in a 4:1 ratio of Omega-6 to [[Omega 3 fatty acid|Omega 3]], and a blend of seeds. She also recommends a low carbohydrate, [[ketogenic diet|high fat]] diet. ==Medical applications== Kane believes her protocol can offer clinical benefit in a range of neurological disorders including [[amyotrophic lateral sclerosis |ALS]], [[Parkinson's disease]], [[Multiple sclerosis]], [[Alzheimer's]], [[autism]], pervasive developmental delay, [[seizure]] disorders, post stroke, [[traumatic brain injury]], metabolic]] and genetic abnormalities. ==Evidence== There have been no clinical trials of the PK protocol for the treatment of any disease. Some of the individual components of the protocol have been studied. ===Sodium phenylbutyrate=== In mouse models of Parkinson's, sodium phenylbutyrate was found to protect the loss of [[dopamine]]rgic neurons.<ref>{{Cite journal | last = Iannitti | first = Tommaso | author-link = | last2 = Palmieri | first2 = Beniamino | authorlink2 = | date = Sep 2011 | title = Clinical and Experimental Applications of Sodium Phenylbutyrate|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586072/|journal=Drugs in R&D|volume=11|issue=3|pages=227–249|doi=10.2165/11591280-000000000-00000|issn=1174-5886|pmc=3586072|pmid=21902286|access-date=|quote=|via=}}</ref><ref>{{Cite journal | last = Freed | first = Curt R. | last2 = Lebin | first2 = Jacob | last3 = Luong | first3 = Nancy | last4 = Cummiskey | first4 = Jessica | last5 = Bercury | first5 = Kathryn | last6 = Zhou | first6 = Wenbo | date = 2011-04-29 | title = Phenylbutyrate Up-regulates the DJ-1 Protein and Protects Neurons in Cell Culture and in Animal Models of Parkinson Disease|url=http://www.jbc.org/content/286/17/14941|journal=Journal of Biological Chemistry|language=en|volume=286|issue=17|pages=14941–14951|doi=10.1074/jbc.M110.211029|issn=0021-9258|pmid=21372141}}</ref><ref>{{Cite journal | last = Pahan | first = Kalipada | last2 = Gendelman | first2 = Howard E. | last3 = Brahmachari | first3 = Saurav | last4 = Liu | first4 = Xiaojuan | last5 = Jana | first5 = Arundhati | last6 = Ghosh | first6 = Anamitra | last7 = Roy | first7 = Avik | date = 2012-06-18 | title = Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease|url=https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038113|journal=PLOS ONE|language=en|volume=7|issue=6| pages = e38113|doi=10.1371/journal.pone.0038113|issn=1932-6203|pmc=3377667|pmid=22723850}}</ref> ==See also== *[[Omega 3 fatty acid hypothesis]] ==References== {{Reflist}} [[Category:Protocols]] [[Category:Potential treatments]] [[Category:Diets]]
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