Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Oxidative phosphorylation
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
{{Stub}} The '''oxidative phosphorylation''' or '''OXPHOS''' or '''OX-PHOS''' pathway, along with [[glycolysis]] are the two main energy-generating mitochondrial pathways.<ref name="Silvestre2019" /> ==Function== The oxidative phosphorylation pathway produces more than 95% of a cell's energy in the form of [[adenosine triphosphate|ATP]]. This is done by the [[mitochondria]], in a process called chemiosmosis.<ref name="Bio2e_7-4">{{Cite book |vauthors = Clark MA, Douglas M, Choi J|publisher=OpenStax | title = Biology 2e|chapter=Oxidative Phosphorylation | date = Mar 28, 2018 | location=Houston, Texas | url = https://openstax.org/books/biology-2e/pages/7-4-oxidative-phosphorylation}}</ref><ref name="dict">{{Cite web|website=Merrian-Webster Medical Dictionary|access-date=2021-02-20 | title = Definition of Oxidative phosphorylation | url = https://www.merriam-webster.com/dictionary/oxidative%20phosphorylation}}</ref><ref name="Brit">{{Cite web | url = https://www.britannica.com/science/oxidative-phosphorylation|website=Encyclopedia Britannica | title = Oxidative Phosphorylation |access-date = 2021-02-20}}</ref> ==ME/CFS== Vermeulen et al. (2010) conducted a small controlled trial of 15 female patients who performed a [[two-day cardiopulmonary exercise test]] (C-PET) and found that patients had a much lower oxygen consumption when they reached their anaerobic threshold on the maximal exercise test compared to controls, and this was much worse on the second test. Levels of oxygen phosphorylation was similar in patients and controls and creatin kinase remained low, suggesting lactate in patients was higher and mitochondrial ATP production was lower.<ref name="Vermeulen2010" /> They concluded that results suggested normal muscular mitochondrial oxidative phosphorylation lactate, and that did not show defects in mitochondrial oxidative phosphorylation.<ref name="Vermeulen2010" /> Silvestre et al. (2019) found that oxidative phosphorylation was deregulated in [[ME/CFS]] patients.<ref name="Silvestre2019" /> ==Notable studies == *2010, Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity<ref name="Vermeulen2010">{{Cite journal | last1 = Vermeulen | first1 = RC | author-link1 = | last2 = Kirk | first2 = RM | authorlink2 =| last3 = Visser | first3 = FC | authorlink3 = Frans Visser | last4 = Sluiter | first4 = W | authorlink4 =| last5 =Scholte | first5 = HR | authorlink5 = | title = Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity | journal = Journal of Translational Medicine | volume = 8 | issue = | page = 93 | date = October 2010 | pmid = 20937116 | doi = 10.1186/1479-5876-8-93}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964609/ (Full text)] *2019, Mitochondrial alterations in NK lymphocytes from ME/CFS patients<ref name="Silvestre2019">{{Cite journal | last = Barao-Silvestre | first = Isabel | authorlink = Isabel Barao-Silvestre | last2 = Dagda | first2 = Raul Y. | author-link2 = | last3 = Dagda | first3 = Ruben K. | author-link3 = | last4 = Darley-Usmar | first4 = Victor | author-link4 = | date = 2019-05-01 | title = Mitochondrial alterations in NK lymphocytes from ME/CFS patients |url = https://www.jimmunol.org/content/202/1_Supplement/126.39 | journal=The Journal of Immunology |language=en|volume=202|issue=1 Supplement|pages=126.39β126.39|doi=|issn=0022-1767|pmc=|pmid=|access-date=|quote=|via=}}</ref> [https://www.jimmunol.org/content/202/1_Supplement/126.39 (Abstract)] * 2020, A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction<ref name="Sweetman2020">{{Cite journal | last = Sweetman | first = Eiren | author-link = | last2 = Kleffmann | first2 = Torsten | author-link2 = | last3 = Edgar | first3 = Christina | authorlink3 = | last4 = de Lange | first4 = Michel | author-link4 = | last5 = Vallings | first5 = Rosamund | author-link5 = Rosamund Vallings | last6 = Tate | first6 = Warren | author-link6 = Warren Tate | date = 2020-09-24 | title = A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction | url = https://doi.org/10.1186/s12967-020-02533-3|journal=Journal of Translational Medicine|volume=18|issue=1|pages=365|doi=10.1186/s12967-020-02533-3|issn=1479-5876|pmc=7512220|pmid=|access-date=|quote=|via=}}</ref> - [https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02533-3 (Full text)] ==See also== * [[Adenosine triphosphate]] (ATP) *[[Mitochondria]] ==Learn more== *[https://openstax.org/books/biology-2e/pages/7-4-oxidative-phosphorylation Oxidative Phosphorylation] - OpenStax ==References== {{reflist}} [[Category:Metabolic pathways]] [[Category:Energy system]] [[Category:Biochemistry and cell biology]] [[Category:Cellular respiration]]
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Templates used on this page:
Template:Asbox
(
edit
)
Template:Cite book
(
edit
)
Template:Cite journal
(
edit
)
Template:Cite web
(
edit
)
Template:Full stop
(
edit
)
Template:Full stop character
(
edit
)
Template:GetFallback
(
edit
)
Template:Help improve text
(
edit
)
Template:LangSwitch
(
edit
)
Template:Main other
(
edit
)
Template:No fullstop
(
edit
)
Template:No fullstop/first
(
edit
)
Template:Reflist
(
edit
)
Template:Str endswith
(
edit
)
Template:Stub
(
view source
) (semi-protected)
Template:Stub text
(
edit
)
Template:Uselang
(
edit
)
Module:Arguments
(
edit
)
Module:Asbox
(
edit
)
Module:Buffer
(
edit
)
Module:Check for unknown parameters
(
edit
)
Module:Citation/CS1
(
edit
)
Module:Citation/CS1/COinS
(
edit
)
Module:Citation/CS1/Configuration
(
edit
)
Module:Citation/CS1/Date validation
(
edit
)
Module:Citation/CS1/Identifiers
(
edit
)
Module:Citation/CS1/Utilities
(
edit
)
Module:Citation/CS1/Whitelist
(
edit
)
Module:Navbar
(
edit
)
Module:No globals
(
edit
)
Module:String
(
edit
)
This page is a member of 2 hidden categories:
Category:All stub articles
Category:Stub pages last edited in 2023
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs