Oxaloacetate
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Oxaloacetate or oxaloacetic acid (OAA) or Anhydrous Enol-Oxaloacetate or (AEO), also available under the brand name Jubilance, is nutritional supplement currently under investigation as a treatment for chronic fatigue and mental fatigue in ME/CFS[1] and Long COVID.[2] The Jubilance brand has limited evidence that it "may help alleviate the mild to moderate psychological and/or behavioral symptoms associated with Premenstrual Syndrome (PMS)".[3]
Theory[edit | edit source]
Oxaloacetate is produced by the body, and additional oxaloacetate may provide mitochondria support in ME/CFS.[citation needed]
Evidence[edit | edit source]
In 2022, Cash et al. (2022) reported:
- "Anhydrous Enol-Oxaloacetate, (AEO) a nutritional supplement, has been anecdotally reported to relieve physical and mental fatigue and is dimished in ME/CFS patients. Here, we examine the use of higher dosage AEO as a medical food to relieve pathological fatigue."
"76 ME/CFS patients (73.7% women, median age of 47) showed an average reduction in fatigue at 6 weeks as measured by the "Chalder Fatigue Questionnaire" of 22.5% to 27.9% from baseline (P < 0.005) (Likert scoring).
Clinicians[edit | edit source]
Risks and safety[edit | edit source]
Costs and availability[edit | edit source]
Notable studies[edit | edit source]
- 2022, Oxaloacetate Treatment For Mental And Physical Fatigue In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long-COVID fatigue patients: a non-randomized controlled clinical trial[4] - (Full text)
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- ↑ Terra Biological LLC; Bateman Horne Center (February 28, 2022). "A Randomized Double Blind Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in ME/CFS". ClinicalTrials.gov. Retrieved August 29, 2022.
- ↑ Terra Biological LLC (October 16, 2020). "Anhydrous Enol-Oxaloacetate (AEO) on Improving Fatigue in Post-COVID-19 Survivors". clinicaltrials.gov.
- ↑ Tully, Lisa; Humiston, John; Cash, Alan (March 2020). "Oxaloacetate reduces emotional symptoms in premenstrual syndrome (PMS): results of a placebo-controlled, cross-over clinical trial". Obstetrics & Gynecology Science. 63 (2): 195–204. doi:10.5468/ogs.2020.63.2.195. ISSN 2287-8572. PMC 7073356. PMID 32206660.
- ↑ Cash, Alan; Kaufman, David Lyons (June 28, 2022). "Oxaloacetate Treatment For Mental And Physical Fatigue In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long-COVID fatigue patients: a non-randomized controlled clinical trial". Journal of Translational Medicine. 20 (1): 295. doi:10.1186/s12967-022-03488-3. ISSN 1479-5876. PMC 9238249. PMID 35764955.
