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Oxaloacetate
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{{stub}} '''Oxaloacetate''' or '''oxaloacetic acid''' '''(OAA)''' or '''Anhydrous Enol-Oxaloacetate''' or '''(AEO)''', also available under the brand name '''Jubilance''', is nutritional supplement currently under investigation as a treatment for [[chronic fatigue]] and mental fatigue in [[ME/CFS]]<ref name="NCT05273372">{{Cite web| title = A Randomized Double Blind Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in ME/CFS| date = 2022-02-28|url=https://clinicaltrials.gov/ct2/show/NCT05273372 | website = ClinicalTrials.gov | last = Terra Biological LLC | first = | authorlink = | last2 = Bateman Horne Center | first2 = | authorlink2 = Bateman Horne Center|access-date=Aug 29, 2022|quote=|via=}}</ref> and [[Long COVID]].<ref name="NCT04592354">{{Cite web| title = Anhydrous Enol-Oxaloacetate (AEO) on Improving Fatigue in Post-COVID-19 Survivors| date = 2020-10-16 | website = clinicaltrials.gov|url=https://clinicaltrials.gov/ct2/show/NCT04592354 | last = Terra Biological LLC}}</ref> The Jubilance brand has limited evidence that it "may help alleviate the mild to moderate psychological and/or behavioral symptoms associated with [[Premenstrual syndrome|Premenstrual Syndrome]] (PMS)".<ref name="TullyPMS2021">{{Cite journal| title = Oxaloacetate reduces emotional symptoms in premenstrual syndrome (PMS): results of a placebo-controlled, cross-over clinical trial| date = Mar 2020|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073356/|journal=Obstetrics & Gynecology Science|volume=63|issue=2|pages=195–204 | last = Tully | first = Lisa | authorlink = | last2 = Humiston | first2 = John | author-link2 = | last3 = Cash | first3 = Alan | authorlink3 = |doi=10.5468/ogs.2020.63.2.195|pmc=7073356|pmid=32206660|access-date=|issn=2287-8572|quote=|via=}}</ref> ==Theory== Oxaloacetate is produced by the body, and additional oxaloacetate may provide [[mitochondria]] support in ME/CFS.{{citation needed| date = 2022}} ==Evidence== In 2022, Cash et al. (2022) reported: :"Anhydrous Enol-Oxaloacetate, (AEO) a nutritional supplement, has been anecdotally reported to relieve physical and mental fatigue and is dimished in ME/CFS patients. Here, we examine the use of higher dosage AEO as a medical food to relieve pathological fatigue." "76 ME/CFS patients (73.7% women, median age of 47) showed an average reduction in fatigue at 6 weeks as measured by the "[[chalder fatigue syndrome|Chalder Fatigue Questionnaire]]" of 22.5% to 27.9% from baseline (P < 0.005) (Likert scoring). ==Clinicians== ==Risks and safety== ==Costs and availability== ==Notable studies == * 2022, Oxaloacetate Treatment For Mental And Physical Fatigue In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long-COVID fatigue patients: a non-randomized controlled clinical trial<ref name="Cash2022">{{Cite journal| title = Oxaloacetate Treatment For Mental And Physical Fatigue In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long-COVID fatigue patients: a non-randomized controlled clinical trial| date = 2022-06-28|url=https://doi.org/10.1186/s12967-022-03488-3|journal=Journal of Translational Medicine|volume=20|issue=1|pages=295 | last = Cash | first = Alan | authorlink = | last2 = Kaufman | first2 = David Lyons | authorlink2 = David Kaufman|doi=10.1186/s12967-022-03488-3|pmc=PMC9238249|pmid=35764955|access-date=|issn=1479-5876|quote=|via=}}</ref> - [https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03488-3 (Full text)] ==See also== ==Learn more== <!-- *Outside articles: e.g. WebMD, Merck Manual, drugs.com, drugbank.ca, Memorial Sloan Kettering, or ScienceDirect --> ==References== {{reflist}} [[Category:Potential treatments]] [[Category:Alternative medicine]] [[Category:Medicinal foods]] [[Category:Supplements]]
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