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==ME/CFS== Obesity is not considered a [[:Category:Triggers and risk factors|trigger or risk factor]] for ME/CFS, and is not a sign or symptom of ME/CFS. Obesity is a [[differential diagnosis]] for ME/CFS and it can cause [[fatigue]]; clinicians are advised to consider this along with other symptoms, test results, and a personal history (e.g. whether symptoms began suddenly or any recent weight change).<ref name="ICC2011primer">{{citation | last1 = Carruthers | first1 = BM | authorlink1 = Bruce Carruthers | last2 = van de Sande | first2 = MI | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = KL | authorlink3 = Kenny de Meirleir | last4 = Klimas | first4 = NG | authorlink4 = Nancy Klimas | last5 = Broderick | first5 = G | authorlink5 = Gordon Broderick | last6 = Mitchell | first6 = T | authorlink6 = Terry Mitchell | last7 = Staines | first7 = D | authorlink7 = Donald Staines | last8 = Powles | first8 = ACP | authorlink8 = A C Peter Powles | last9 = Speight | first9 = N | authorlink9 = Nigel Speight | last10 = Vallings | first10 = R | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = L | authorlink11 = Lucinda Bateman | last12 = Bell | first12 = DS | authorlink12 = David Bell | last13 = Carlo-Stella | first13 = N | authorlink13 = Nicoletta Carlo-Stella | last14 = Chia | first14 = J | authorlink14 = John Chia | last15 = Darragh | first15 = A | authorlink15 = Austin Darragh | last16 = Gerken | first16 = A | authorlink16 = Anne Gerken | last17 = Jo | first17 = D | authorlink17 = Daehyun Jo | last18 = Lewis | first18 = DP | authorlink18 = Donald Lewis | last19 = Light | first19 = AR | authorlink19= Alan Light | last20 = Light | first20 = KC | authorlink20 = Kathleen Light | last21 = Marshall-Gradisnik | first21 = S | authorlink21 = Sonya Marshall-Gradisnik | last22 = McLaren-Howard | first22 = J | authorlink22 = John McLaren-Howard | last23 = Mena | first23 = I | authorlink23 = Ismael Mena | last24 = Miwa | first24 = K | authorlink24 = Kunihisa Miwa | last25 = Murovska | first25 = M | authorlink25= Modra Murovska | last26 = Stevens | first26 = SR | authorlink26 = Staci Stevens | title = Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners | date = 2012| isbn = 978-0-9739335-3-6 | url = http://www.investinme.org/Documents/Guidelines/Myalgic%20Encephalomyelitis%20International%20Consensus%20Primer%20-2012-11-26.pdf}}</ref><ref name="canadianconsensus-CCC">{{Citation | last1 = Carruthers | first1 = Bruce M. | authorlink1 = Bruce Carruthers | last2 = Jain | first2 = Anil Kumar | authorlink2 = Anil Kumar Jain | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Peterson | first4 = Daniel L. | authorlink4 = Daniel Peterson | last5 = Klimas | first5 = Nancy G. | authorlink5 = Nancy Klimas | last6 = Lerner | first6 = A. Martin | authorlink6 = Martin Lerner | last7 = Bested | first7 = Alison C. | authorlink7 = Alison Bested | last8 =Flor-Henry | first8 = Pierre | authorlink8 = Pierre Flor-Henry | last9 = Joshi | first9 = Pradip | authorlink9 = Pradip Joshi | last10 = Powles | first10 = AC Peter | authorlink10 = A C Peter Powles | last11 = Sherkey | first11 = Jeffrey A. | authorlink11 = Jeffrey Sherkey | last12 = van de Sande | first12 = Marjorie I. | authorlink12 = Marjorie van de Sande | title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols| journal = Journal of Chronic Fatigue Syndrome | volume = 11 | issue = 2 | pages = 7-115 | date = 2003 | pmid = | doi = 10.1300/J092v11n01_02| url = http://www.investinme.org/Documents/PDFdocuments/CanadianDefinitionME-CFS.pdf}}</ref> According to the US ME/CFS Clinician Coalition, obesity is a potential comorbidity in people with ME/CFS, although it is not listed as a common comorbidity in either the [[Canadian Consensus Criteria]] or the [[International Consensus Criteria]].<ref name="UScoalition2020">{{Cite web | title = Diagnosing and Treating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) | last=U.S. ME/CFS Clinician Coalition |edition=2 | date = July 2020 | url= https://bridgesandpathways.org.au/wp-content/uploads/2021/02/DiagnosingAndTreatingMECFSV2_USCoalition_2020.pdf | pages = 4}}</ref> ===Weight changes in ME/CFS === Medications taken for some ME/CFS symptoms can increase weight, particularly: *[[amitriptyline]] and other [[:Category:Tricyclic antidepressants|tricyclic antidepressants]], which are often used for [[pain]], especially in [[Fibromyalgia]], or for [[sleep dysfunction]] *[[quetiapine]], which may be used off-label for sleep problems *[[Lyrica]] (pregabelin) which is commonly used for pain<ref name="canadianconsensus-CCC" /> Marked [[weight loss]] or [[weight gain]] can also be a result of the [[neuroendocrine symptoms]] in some people with ME/CFS, or result from changed behaviors caused by [[reactive depression]], which is relatively common in ME/CFS.<ref name="canadianconsensus-CCC" /> ===Exercise === The [[exercise intolerance]] caused by ME/CFS means that many patients are unable to do as much physical activity as they would like to. Physical activity and a [[healthy, balanced diet]] are the main ways to prevent and reduce obesity.<ref name="management">{{Cite web|url=https://www.cdc.gov/obesity/strategies/index.html | title = Strategies to Prevent & Manage Obesity {{!}} Overweight & Obesity | last = | first = | authorlink = | date = 2021-04-09 | website = CDC|language=en-us|archive-url=|archive-date=|url-status=|access-date=2022-01-11}}</ref>
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