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Nortriptyline
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'''Nortriptyline''' is a tricyclic [[antidepressant]].<ref name="medline">{{Cite web|url=https://medlineplus.gov/druginfo/meds/a682620.html | title = Nortriptyline: MedlinePlus Drug Information|website=medlineplus.gov|language=en|access-date=2019-01-08}}</ref> It is also marketed under the brand names Aventyl and Pamelor.<ref name="medline" /> ==Theory== ==Potential uses== Nortriptyline is licensed for use for clinical [[depression]], and may be used off-label for [[anxiety]], [[sleep dysfunction|insomnia or sleep problems]], nerve pain or [[chronic pain]].<ref name="drugscom">{{Cite web|url=https://www.drugs.com/nortriptyline.html | title = Nortriptyline: Uses, Dosage & Side Effects|website=Drugs.com|language=en|access-date=2021-02-12}}</ref><ref name="VRPS">{{Cite web|url=https://www.nhs.uk/conditions/complex-regional-pain-syndrome/treatment/ | title = Complex regional pain syndrome - Treatment | last = | first = | authorlink = National Health Service | date = 2017-10-19 | website = National Health Service|language=en|archive-url=|archive-date=|url-status=|access-date=2021-02-12}}</ref> ==Evidence == A [[Cochrane]] review in 2015 found insufficient evidence to recommend nortriptyline for [[pain#neuropathic_pain|nerve pain]] in adults.<ref name="CochranePain">{{Cite web|url=https://www.cochrane.org/CD011209/SYMPT_nortriptyline-neuropathic-pain-adults | title = Nortriptyline for neuropathic pain in adults | last = | first = | authorlink = Cochrane | date = 2015 | website = Cochrane|language=en|archive-url=|archive-date=|url-status=|access-date=2021-02-12}}</ref> The medical practitioners' primer for the [[International Consensus Criteria]] of [[myalgic encephalomyelitis]] suggests nortriptyline may be useful for pain in patients with ME/CFS, but suggests other drugs for sleep problems and [[Depression#Secondary|secondary depression]]. There is more evidence for the use of nortriptyline in [[fibromyalgia]].<ref name="ICC2011primer" /> ==Risks and safety == Side effects can be severe.<ref name="ICC2011primer">{{citation | last1 = Carruthers | first1 = BM | authorlink1 = Bruce Carruthers | last2 = van de Sande | first2 = MI | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = KL | authorlink3 = Kenny de Meirleir | last4 = Klimas | first4 = NG | authorlink4 = Nancy Klimas | last5 = Broderick | first5 = G | authorlink5 = Gordon Broderick | last6 = Mitchell | first6 = T | authorlink6 = Terry Mitchell | last7 = Staines | first7 = D | authorlink7 = Donald Staines | last8 = Powles | first8 = ACP | authorlink8 = A C Peter Powles | last9 = Speight | first9 = N | authorlink9 = Nigel Speight | last10 = Vallings | first10 = R | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = L | authorlink11 = Lucinda Bateman | last12 = Bell | first12 = DS | authorlink12 = David Bell | last13 = Carlo-Stella | first13 = N | authorlink13 = Nicoletta Carlo-Stella | last14 = Chia | first14 = J | authorlink14 = John Chia | last15 = Darragh | first15 = A | authorlink15 = Austin Darragh | last16 = Gerken | first16 = A | authorlink16 = Anne Gerken | last17 = Jo | first17 = D | authorlink17 = Daehyun Jo | last18 = Lewis | first18 = DP | authorlink18 = Donald Lewis | last19 = Light | first19 = AR | authorlink19 = Alan Light | last20 = Light | first20 = KC | authorlink20 = Kathleen Light | last21 = Marshall-Gradisnik | first21 = S | authorlink21 = Sonya Marshall-Gradisnik | last22 = McLaren-Howard | first22 = J | authorlink22 = John McLaren-Howard | last23 = Mena | first23 = I | authorlink23 = Ismael Mena | last24 = Miwa | first24 = K | authorlink24 = Kunihisa Miwa | last25 = Murovska | first25 = M | authorlink25= Modra Murovska | last26 = Stevens | first26 = SR | authorlink26 = Staci Stevens | title = Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners | date = 2012 | isbn = 978-0-9739335-3-6 | url = http://www.investinme.org/Documents/Guidelines/Myalgic%20Encephalomyelitis%20International%20Consensus%20Primer%20-2012-11-26.pdf }}</ref> ==Costs and availability== Nortriptyline is an inexpensive prescription-only medicine. ==Learn more == *[https://medlineplus.gov/druginfo/meds/a682620.html Nortriptyline: MedlinePlus Drug Information] *[https://www.drugs.com/nortriptyline.html Nortriptyline - drugs.com] ==See also == *[[Amitriptyline]] ==References== {{reflist}} {{stub}} [[Category:Antidepressants]] [[Category:Potential treatments]] [[Category:Analgesics]] [[Category:Sleep aids and hypnotics]] [[Category:Sedating antidepressants]] [[Category:Tricyclic antidepressants]]
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