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Nitric oxide hypothesis
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The '''NO/ONOO''' cycle (pronounced no/oh no) is also known as the nitric oxide cycle theory, is a hypothesis developed by Dr [[Martin Pall]]. ==Theory== Dr [[Martin Pall|Martin L. Pall]] states: "I propose here a novel hypothesis of [[Chronic fatigue syndrome|CFS]] in which either viral or bacterial [[infection]] induces one or more [[Cytokine|cytokines]], [[Interleukin 1|IL-1beta]] [[Interleukin 6|IL-6]], [[TNF-alpha]] and [[IFN-gamma]]. These induce [[nitric oxide]] synthase (iNOS), leading to increased nitric oxide levels. Nitric oxide, in turn, reacts with [[superoxide radicals]] to generate the potent oxidant [[peroxynitrite]]. Multiple amplification and positive feedback mechanisms are proposed by which once peroxynitrite levels are elevated, they tend to be sustained at a high level."<ref>{{Cite journal | last = Pall | first = Martin L. | authorlink = Martin Pall | date = Jan 2000 | title = Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/10790736|journal=Medical Hypotheses|volume=54|issue=1|pages=115β125|doi=10.1054/mehy.1998.0825|issn=0306-9877|pmid=10790736|quote=|via=}}</ref> ==Evidence== == Notable studies == ==Learn more== *[http://www.townsendletter.com/FebMarch2010/cureNO0210.html How Can We Cure NO/ONOOβ Cycle Diseases?], Martin L. Pall, 2010 *[http://phoenixrising.me/archives/18836 Nitric oxide and its possible implication in ME/CFS (Part 1 of 2)], Phoenix Rising, August 25, 2014 *[http://phoenixrising.me/archives/25528 Nitric oxide and its possible implication in ME/CFS (Part 2 of 2)], Phoenix Rising, August 28, 2014 *[https://www.sciencedirect.com/science/article/pii/B9780080450469006847 Nitric oxide - Encyclopaedia of Neuroscience] *[http://www.cortjohnson.org/forums/threads/fluge-mella-take-out-patent-on-nitric-oxide-treatment-for-me-cfs.2829/ Fluge/Mella Take out Patent on Nitric Oxide Treatment for ME/CFS], Health Rising, Jul 31, 2015 ==See also== *[[Martin Pall]] *[[Nitric oxide]] *[[Explaining "Unexplained Illnesses"|Explaining "Unexplained illnesses"]] *[[N-acetylcysteine]] *[[Neurotransmitter]] == References == {{Reflist}} [[Category:Medical hypotheses]] [[Category:Energy system]] [[Category:Immunology]]
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