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Nightingale Research Foundation definition
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====5. Diffuse Brain Injury Observed on Brain SPECT==== If the patient’s illness is not measurable using a dedicated brain [[SPECT]] scan such as a Picker 3000 or equivalent, then the patient does not have M.E. For legal purposes these changes may be confirmed by PET [[brain scans]] with appropriate software and /or [[QEEG]]. These changes can be roughly characterized as to severity and probable chronicity using the following two scales: '''A)''' Extent of injury and '''B)''' degree of injury of CNS vascular function. :'''Extent of Injury''' ::'''Type 1:''' One side of the cortex is involved. Those patients labeled as 1A have the best chance of recovery. ::'''Type 2:''' Both sides of the cortex are involved. These patients have the least chance of spontaneous recovery. ::'''Type 3:''' Both sides of the cortex, and either one or all of the following: posterior chamber organs, (the pons and cerebellum), limbic system, the subcortical and brainstem structures are involved. Type 3B are the most severely affected patients and the most likely to be progressive or demonstrate little or no improvement with time. :'''Degree of injury''' ::'''Type A:''' Anatomical integrity is largely maintained in the Brain SPECT scan. ::'''Type B:''' Anatomical integrity is not visible in the CNS SPECT scan. Type 3B are some of the most severely and chronically injured patients.
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