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Neural strain
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=== Compression === Compression of nerves can result in low blood flow;<ref>{{Cite journal | last = Rydevik | first = B. | last2 = Lundborg | first2 = G. | last3 = Bagge | first3 = U. | date = 1981-01-01 | title = Effects of graded compression on intraneural blood flow: An in vivo study on rabbit tibial nerve|url=http://www.sciencedirect.com/science/article/pii/S0363502381800032|journal=The Journal of Hand Surgery|volume=6|issue=1|pages=3β12|doi=10.1016/S0363-5023(81)80003-2|issn=0363-5023}}</ref> changes in microcirculation and ischemia;<ref>{{Cite journal | last = Rydevik | first = B. | last2 = Lundborg | first2 = G. | last3 = Bagge | first3 = U. | date = 1981-01-01 | title = Effects of graded compression on intraneural blood flow: An in vivo study on rabbit tibial nerve|url=http://www.sciencedirect.com/science/article/pii/S0363502381800032|journal=The Journal of Hand Surgery|volume=6|issue=1|pages=3β12|doi=10.1016/S0363-5023(81)80003-2|issn=0363-5023}}</ref> changes in vascular permeability, edema,<ref>{{Cite journal | last = Powell | first = H. | last2 = Myers | first2 = R. | last3 = Lundborg | first3 = G. | date = 1983-12-01 | title = Nerve compression injury and increased endoneurial fluid pressure: a "miniature compartment syndrome".|url=https://jnnp.bmj.com/content/46/12/1119|journal=Journal of Neurology, Neurosurgery & Psychiatry|language=en|volume=46|issue=12|pages=1119β1124|doi=10.1136/jnnp.46.12.1119|issn=0022-3050|pmid=6663311}}</ref> axonal damage; and has been associated with demyelination.<ref name=":0" /><ref>{{Cite journal | last = Myers | first = R.R. | last2 = Powell | first2 = H.C. | date = Jul 1986 | title = Pathology of experimental nerve compression.|url=http://europepmc.org/abstract/med/3724067|journal=Laboratory investigation; a journal of technical methods and pathology|volume=55|issue=1 | pages = 91β100|issn=0023-6837|pmid=3724067}}</ref><ref>{{Cite journal | last = Dahlin | first = L.B. | last2 = Lundborg | first2 = G. | date = Jun 1992 | title = The pathophysiology of nerve compression.|url=http://europepmc.org/abstract/med/1613031|journal=Hand clinics|volume=8|issue=2|pages=215β227|issn=0749-0712|pmid=1613031}}</ref><ref>{{Cite journal | last = Dahlin | first = L.B. | last2 = Lundborg | first2 = G. | date = May 1996 | title = Anatomy, function, and pathophysiology of peripheral nerves and nerve compression.|url=http://europepmc.org/abstract/med/8724572|journal=Hand clinics|volume=12|issue=2|pages=185β193|issn=0749-0712|pmid=8724572}}</ref> Prologned compression can result in [[inflammation]] and activation of endoneurial fibroblasts, mast cells, and macrophages.<ref>{{Cite journal | last = Powell | first = H.C. | last2 = Myers | first2 = R.R. | date = Jul 1986 | title = Pathology of experimental nerve compression | url =https://www.ncbi.nlm.nih.gov/pubmed/3724067|journal=Laboratory Investigation; a Journal of Technical Methods and Pathology|volume=55|issue=1 | pages = 91β100|issn=0023-6837|pmid=3724067}}</ref>
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