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[[File:Nancy klimas.jpg|thumb]] | [[File:Nancy klimas.jpg|thumb]] | ||
'''Nancy G. Klimas''', MD, is an American researcher and physician who is the Director at the [[Institute for Neuro Immune Medicine]] at Nova Southeastern University in Miami and Ft. Lauderdale, Florida. She is, also: Director of Clinical Immunology Research, Miami VAMC; Professor of Medicine, Department of Clinical Immunology, College of Osteopathic Medicine, Nova Southeastern University; Chair, Department of Clinical Immunology, College of Osteopathic Medicine, Nova Southeastern University; and Professor Emerita, University of Miami, School of Medicine.<ref>http://www.nova.edu/nim/clinic/dr.-nancy-klimas-bio-page.html</ref> | '''Nancy G. Klimas''', MD, is an American researcher and physician who is the Director at the [[Institute for Neuro Immune Medicine]] at Nova Southeastern University in Miami and Ft. Lauderdale, Florida. She is, also: Director of Clinical Immunology Research, Miami VAMC; Professor of Medicine, Department of Clinical Immunology, College of Osteopathic Medicine, Nova Southeastern University; Chair, Department of Clinical Immunology, College of Osteopathic Medicine, Nova Southeastern University; and Professor Emerita, University of Miami, School of Medicine.<ref name="bio">http://www.nova.edu/nim/clinic/dr.-nancy-klimas-bio-page.html</ref> | ||
==Awards== | ==Awards== | ||
*2011, Nelson Gantz Outstanding Clinician Award awarded to a physician who emulates Nelson Gantz's clinical acumen, his passion for medicine, and his empathy for persons with CFS/FM awarded by [[IACFS/ME]]<ref name=":0">{{Cite web|url= | *2011, Nelson Gantz Outstanding Clinician Award awarded to a physician who emulates Nelson Gantz's clinical acumen, his passion for medicine, and his empathy for persons with CFS/FM awarded by [[International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis|IACFS/ME]]<ref name=":0">[[International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis]]{{Cite web|url=https://www.iacfsme.org/iacfs-me-awardees | title = IACFS/ME Awardees|website= | ||
*2014, Rudy Perpich Senior Lectureship Award, presented to a distinguished [[CFS]]/[[FMS]] scientist, physician or healthcare worker awarded by [[IACFS/ME]].<ref name=":0" /> | IACFS/ME|access-date=2020-04-23}}</ref> | ||
*2014, Rudy Perpich Senior Lectureship Award, presented to a distinguished [[Chronic fatigue syndrome|CFS]]/[[fibromyalgia|FMS]] scientist, physician or healthcare worker awarded by [[International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis|IACFS/ME]].<ref name=":0" /> | |||
== Committees == | == Committees == | ||
=====2015 Institute of Medicine report===== | =====2015 Institute of Medicine report===== | ||
Dr. Klimas was one of the [[ME/CFS]] experts on the "Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome" that was convened to produce the 2015 [[Institute of Medicine report]].<ref>{{Cite web|url=http://iom.nationalacademies.org/~/media/Files/Report%20Files/2015/MECFS/MECFScliniciansguide.pdf|title=Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Redefining an Illness|last=Clayton|first=Ellen Wright|date=2015|website= | * Dr. Klimas was one of the [[ME/CFS]] experts on the "Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome" that was convened to produce the 2015 [[Institute of Medicine report]].<ref>{{Cite web|url=http://iom.nationalacademies.org/~/media/Files/Report%20Files/2015/MECFS/MECFScliniciansguide.pdf | title = Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Redefining an Illness | last = Clayton | first = Ellen Wright | date = 2015 | website = National Academies|archive-url=|archive-date=|url-status=|access-date= | authorlink = Ellen Wright Clayton | last2 = Alegria | first2 = Margarita | authorlink2 = Margarita Alegria | authorlink3 = Lucinda Bateman | authorlink4 = Lily Chu | authorlink5 = Charles Cleeland | authorlink6 = Ronald Davis | authorlink7 = Betty Diamond | authorlink8 = Theodore Ganiats | authorlink9=Betsy Keller | last3 = Bateman | first3 = Lucinda | last4 = Chu | first4 = Lily | last5 = Cleeland | first5 = Charles | last6 = Davis | first6 = Ronald | last7 = Diamond | first7 = Betty | last8 = Ganiats | first8 = Theodore | last9 = Keller | first9 = Betsy | last10 = Klimas | first10 = Nancy | authorlink10=Nancy Klimas | last11 = Lerner | first11 = A Martin | authorlink11=Martin Lerner | last12 = Mulrow | first12 = Cynthia | authorlink12=Cynthia Mulrow | last13 = Natelson | first13 = Benjamin | authorlink13 = Benjamin Natelson | last14 = Rowe | first14 = Peter | authorlink14=Peter Rowe | last15 = Shelanski | first15 = Michael | authorlink15=Michael Shelanski}}</ref> | ||
=====Case definition authorships===== | =====Case definition authorships===== | ||
Klimas is one of the authors of the 2011 case definition, [[International Consensus Criteria]],<ref>{{Cite journal|last=Carruthers|first=Bruce M.| | * Klimas is one of the authors of the 2011 case definition, [[International Consensus Criteria]],<ref name="ICC">{{Cite journal | last = Carruthers | first = Bruce M. | authorlink = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | author-link4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | author-link5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | authorlink6 = Terry Mitchell | last7 = Staines | first7 = Donald | author-link7 = Donald Staines | last8 = Powles | first8 = A.C. Peter | authorlink8 = A C Peter Powles | last9 = Speight | first9 = Nigel | authorlink9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | authorlink11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | authorlink12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | author-link14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | author-link15 = John Chia | last16 = Darragh | first16 = Austin | author-link16 = Austin Darragh | last17 = Jo | first17 = Daehyun | author-link17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> the 2006 Pediatric Case Definition for Myalgic Encephalomyelitis and Chronic Fatigue Syndrome<ref name="JasonL2006paed" />, as well as, one of the authors of the 2003 [[Canadian Consensus Criteria]] for ME/CFS, published as '''Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols'''<ref name="canadianconsensus">{{Cite journal | last1 = Carruthers | first1 = Bruce M. | authorlink1 = Bruce Carruthers | last2 = Jain | first2 = Anil Kumar | authorlink2 = Anil Kumar Jain | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Peterson | first4 = Daniel L. | authorlink4 = Daniel Peterson | last5 = Klimas | first5 = Nancy G. | authorlink5 = Nancy Klimas | last6 = Lerner | first6 = A. Martin | authorlink6 = Martin Lerner | last7 =Bested | first7 = Alison C. | authorlink7 = Alison Bested | last8 = Flor-Henry | first8 = Pierre | authorlink8 = Pierre Flor-Henry | last9 =Joshi | first9 = Pradip | authorlink9 = Pradip Joshi | last10 = Powles | first10 = AC Peter | authorlink10 = A C Peter Powles | last11 = Sherkey | first11 = Jeffrey A. | authorlink11 = Jeffrey Sherkey | last12 = van de Sande | first12 = Marjorie I. | authorlink12 = Marjorie van de Sande | title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols | journal = Journal of Chronic Fatigue Syndrome | volume = 11 | issue = 2 | pages = 7-115 | date = 2003 | pmid = | doi = 10.1300/J092v11n01_02 | url = http://www.investinme.org/Documents/PDFdocuments/CanadianDefinitionME-CFS.pdf }}</ref> | ||
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=====Chronic Fatigue Syndrome Advisory Committee===== | =====Chronic Fatigue Syndrome Advisory Committee===== | ||
Dr. Klimas served as a voting member of the [[Chronic Fatigue Syndrome Advisory Committee]] for the [[U.S. Department of Health and Human Services]] from April 1, 2007 to April 1, 2011.<ref>http://nih.granicus.com/DocumentViewer.php?file=nih_e174f9bd-ae0f-4a45-9955-827cb608db2f.pdf</ref> | * Dr. Klimas served as a voting member of the [[Chronic Fatigue Syndrome Advisory Committee]] for the [[U.S. Department of Health and Human Services]] from April 1, 2007 to April 1, 2011.<ref>http://nih.granicus.com/DocumentViewer.php?file=nih_e174f9bd-ae0f-4a45-9955-827cb608db2f.pdf</ref> | ||
=====International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis===== | =====International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis===== | ||
Dr. Klimas served as past President of the Board of Directors of the [[International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis]] ( | * Dr. Klimas served as past President of the Board of Directors of the [[International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis]] (IACFS/ME) from 2004-2009.<ref>http://iacfsme.org/Organization/Committees-of-the-IACFS-ME.aspx</ref> She has been awarded the IACFS/ME Nelson Gantz Outstanding Clinician Award (in 2011) and the IACFS/ME Rudy Perpich Senior Lectureship Award (in 2014).<ref name=":0" /> | ||
Dr. Klimas serves on the | * Dr. Klimas serves on the editorial board of the journal, [[Fatigue: Biomedicine, Health & Behavior]], published on behalf of the IACFS/ME.<ref>{{Cite web|url=https://www.tandfonline.com/action/journalInformation?show=editorialBoard&journalCode=rftg20& | title = Fatigue: Biomedicine, Health & Behavior|website=Taylor and Francis Online|access-date=2019-11-01}}</ref> | ||
=====ME/CFS Common Data Elements (CDE) Project===== | =====ME/CFS Common Data Elements (CDE) Project===== | ||
Co-chair of the Immune Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the [[National Institute of Neurological Disorders and Stroke]] and the [[Centers for Disease Control | * Co-chair of the Immune Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the [[National Institute of Neurological Disorders and Stroke]] and the [[Centers for Disease Control and Prevention]].<ref>{{Cite web|url=https://www.commondataelements.ninds.nih.gov/Myalgic%20Encephalomyelitis/Chronic%20Fatigue%20Syndrome#pane-138 | title = Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster | last = | first = | authorlink = | date = |website=NIH|archive-url=|archive-date=|url-status=|access-date=2019-10-11}}</ref> | ||
== ME/CFS Gene Study == | == ME/CFS Gene Study == | ||
Nancy Klimas is part of the Institute for Neuroimmune Medicine's [[ME/CFS Gene Study]], which aims to "create a one of a kind genetic database for ME/CFS."<ref name=":1">{{Cite web|url=https://www.nova.edu/nim/research/mecfs-genes.html|title=ME/CFS Genes Study {{!}} NSU Institute for Neuro Immune Medicine|last=Nova Southeastern University|first=|date=|website=NSU|language=en|archive-url=|archive-date=| | Nancy Klimas is part of the Institute for Neuroimmune Medicine's [[ME/CFS Gene Study]], which aims to "create a one of a kind genetic database for ME/CFS."<ref name=":1">{{Cite web|url=https://www.nova.edu/nim/research/mecfs-genes.html | title = ME/CFS Genes Study {{!}} NSU Institute for Neuro Immune Medicine | last = Nova Southeastern University | first = | date = |website=NSU|language=en|archive-url=|archive-date=|url-status=|access-date=2018-11-01}}</ref> The ME/CFS Gene Study is a worldwide internet-based study that asks for either people with ME/CFS or Healthy Controls to submit gene information they have acquired themselves. Participants answer a questionnaire to check they can take part, then arrange their own gene testing through [[23andMe]] or [[Ancestry DNA]], which need saliva samples to be sent by post. They then send the results electronically to the study group.<ref name=":1" /> | ||
==Research studies== | ==Research studies== | ||
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=== Recent studies === | === Recent studies === | ||
*2016, [[Sleep dysfunction|Poor sleep quality]] is associated with greater circulating pro-inflammatory [[cytokines]] and severity and frequency of | *2016, [[Sleep dysfunction|Poor sleep quality]] is associated with greater circulating pro-inflammatory [[cytokines]] and severity and frequency of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) symptoms in women<ref name="Milrad2016">{{Cite journal | last1 = Milrad | first1 = Sara F. | last2 = Hall | first2 = Daniel L. | last3 = Jutagir | first3 = Devika R. | last4 = Lattie | first4 = Emily G. | last5 = Ironson | first5 = Gail H. | last6 = Wohlgemuth | first6 = William | last7 = Vera Nunez | first7 = Maria| authorlink7 = Maria Vera | last8 = Garcia | first8 = Lina | last9 = Czaja | first9 = Sara J. | last10 = Perdomo | first10 = Dolores M. | last11 = Fletcher | first11 = Mary Ann | authorlink11 = Mary Ann Fletcher | last12 = Klimas | first12 = Nancy| authorlink12 = Nancy Klimas | last13 = Antoni | first13 = Michael H. | authorlink13 =Michael Antoni | title = Poor sleep quality is associated with greater circulating pro-inflammatory cytokines and severity and frequency of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) symptoms in women|journal= Journal of Neuroimmunology| volume = 0 | issue = 0 | page = | date = 2016|doi= 10.1016/j.jneuroim.2016.12.008}}</ref> - [http://www.jni-journal.com/action/showFullTextImages?pii=S0165-5728%2816%2930449-0 (Abstract)] | ||
|last1= Milrad| first1 = Sara F.|last2= Hall| first2 = Daniel L.|last3= Jutagir| first3 = Devika R.|last4= Lattie| first4 = Emily G.|last5= Ironson| first5 = Gail H.|last6= Wohlgemuth| first6 = William|last7= Vera Nunez| first7 = Maria| authorlink7 = Maria Vera |last8= Garcia| first8 = Lina|last9= Czaja| first9 = Sara J.|last10= Perdomo| first10 = Dolores M.|last11= Fletcher| first11 = Mary Ann| authorlink11 = Mary Ann Fletcher|last12= Klimas| first12 = Nancy| authorlink12 = Nancy Klimas|last13= Antoni| first13 = Michael H.| authorlink13 =Michael Antoni|title=Poor sleep quality is associated with greater circulating pro-inflammatory cytokines and severity and frequency of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) symptoms in women|journal= Journal of Neuroimmunology| volume = 0| issue = 0 | page =|date= 2016|doi= 10.1016/j.jneuroim.2016.12.008}}</ref> - [http://www.jni-journal.com/action/showFullTextImages?pii=S0165-5728%2816%2930449-0 (Abstract)] | |||
*2016, Illness progression in chronic fatigue syndrome: a shifting immune baseline<ref name="IllnessProgressionBMC2016" /> -[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785654/ (Full Text)] | *2016, Illness progression in chronic fatigue syndrome: a shifting immune baseline<ref name="IllnessProgressionBMC2016" /> -[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785654/ (Full Text)] | ||
*2016, Tracking post-infectious fatigue in clinic using routine Lab tests<ref>{{Cite journal|last=Harvey|first=Jeanna M.|last2=Broderick|first2=Gordon|last3=Bowie|first3=Alanna|last4=Barnes|first4=Zachary M.|last5=Katz|first5=Ben Z.|last6= | *2016, Tracking post-infectious fatigue in clinic using routine Lab tests<ref name="Harvey2016">{{Cite journal | last = Harvey | first = Jeanna M. | authorlink = Jeanna Harvey | last2 = Broderick | first2 = Gordon | authorlink2 = Gordon Broderick | last3 = Bowie | first3 = Alanna | authorlink3 = Alanna Bowie | last4 = Barnes | first4 = Zachary M. | authorlink4 = Zachary Barnes | last5 = Katz | first5 = Ben Z. | authorlink5 = Ben Katz | last6 = O'Gorman | first6 = Maurice R.G. | author-link6 = Maurice O'Gorman | last7 = Vernon | first7 = Suzanne D. | authorlink7 = Suzanne Vernon | last8 = Fletcher | first8 = Mary Ann | authorlink8 = Mary Ann Fletcher | last9 = Klimas | first9 = Nancy G. | authorlink9 = Nancy Klimas | date = 2016-04-26 | title = Tracking post-infectious fatigue in clinic using routine Lab tests|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847210/|journal=BMC Pediatrics|doi=10.1186/s12887-016-0596-8|issn=1471-2431|pmc=4847210|pmid=27118537|volume=15|issue= | pages = 54|quote=}}</ref> - [https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-016-0596-8 (Full Text)] | ||
*2016, Gastric Enterovirus Infection: A Possible Causative Etiology of [[Gastroparesis]]<ref name="BarkinJA, 2016">{{ | *2016, Gastric Enterovirus Infection: A Possible Causative Etiology of [[Gastroparesis]]<ref name="BarkinJA, 2016">{{Cite journal | last1 = Barkin | first1 = JA | authorlink = | last2 = Czul | first2 = F | authorlink2 = | last3 = Barkin | first3 = JS | authorlink3 = | last4 = Klimas | first4 = NG | authorlink4 = Nancy Klimas | last5 = Rey | first5 = IR | authorlink5 = Irma Rey | last6 = Moshiree | first6 = B | authorlink6 = | title = Gastric Enterovirus Infection: A Possible Causative Etiology of Gastroparesis|journal=Digestive Diseases and Sciences|volume=61|issue=8 | page = 2344-50 | date = 2016 | pmid=27344315|doi=10.1007/s10620-016-4227-x}}</ref> - [https://link.springer.com/article/10.1007/s10620-016-4227-x (Abstract)] | ||
*2017, [[Depression]], evening salivary [[cortisol]] and [[inflammation]] in [[chronic fatigue syndrome]]: A psychoneuroendocrinological structural regression model<ref name="Milrad, 2017">{{ | *2017, [[Depression]], evening salivary [[cortisol]] and [[inflammation]] in [[chronic fatigue syndrome]]: A psychoneuroendocrinological structural regression model<ref name="Milrad, 2017">{{Cite journal | last1 = Milrad | first1 = Sara F. | last2 = Hall | first2 = Daniel L. | last3 = Jutagir | first3 = Devika R. | last4 = Lattie | first4 = Emily G. | last5 = Czaja | first5 = Sara J. | last6 = Perdomo | first6 = Dolores M. | last7 = Fletcher | first7 = Mary Ann | authorlink7 = Mary Ann Fletcher | last8 = Klimas | first8 = Nancy | authorlink8 = Nancy Klimas | last9 = Antoni|first9 = Michael H. | author-link9 = Michael Antoni | title = Depression, evening salivary cortisol and inflammation in chronic fatigue syndrome: A psychoneuroendocrinological structural regression model|journal=Int J Psychophysiol| volume = 0 | issue = 0 | page = | date = 2017|doi= 10.1016/j.ijpsycho.2017.09.009}}</ref> - [https://www.sciencedirect.com/science/article/abs/pii/S0167876017301629 (Abstract)] | ||
*2017, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and [[Gulf War Illness]] patients exhibit increased humoral responses to the [[Herpesviruses]]-encoded dUTPase: Implications in disease pathophysiology: | *2017, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and [[Gulf War Illness]] patients exhibit increased humoral responses to the [[Herpesviruses]]-encoded dUTPase: Implications in disease pathophysiology: Herpesviruses in ME/CFS and [[Gulf War Illness]]<ref name="Halpin, 2017" /> - [https://doi.org/10.1002/jmv.24810 (Abstract)] | ||
*2017, Fecal metagenomic profiles in subgroups of patients with | *2017, Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome<ref name="Nagy-Szakal, 2017" /> - [https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-017-0261-y (Full Text)] | ||
*2017, Multi-Site Clinical Assessment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (MCAM): Design and Implementation of a Prospective/Retrospective Rolling Cohort Study<ref name="Unger, 2017" /> - [https://www.ncbi.nlm.nih.gov/pubmed/28338983 (Abstract)] | *2017, Multi-Site Clinical Assessment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (MCAM): Design and Implementation of a Prospective/Retrospective Rolling Cohort Study<ref name="Unger, 2017" /> - [https://www.ncbi.nlm.nih.gov/pubmed/28338983 (Abstract)] | ||
*2017, Telephone-administered versus live group cognitive behavioral stress management for adults with CFS<ref name="Hall, 2017" /> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270375/ (Full Text)] | *2017, Telephone-administered versus live group cognitive behavioral stress management for adults with CFS<ref name="Hall, 2017" /> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270375/ (Full Text)] | ||
*2018, KPAX002 as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A prospective, randomized trial<ref name="Montoya, 2018" /> - [http://www.ijcem.com/files/ijcem0065685.pdf (Full Text)] | *2018, KPAX002 as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A prospective, randomized trial<ref name="Montoya, 2018" /> - [http://www.ijcem.com/files/ijcem0065685.pdf (Full Text)] | ||
*2018, Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive [[metabolomics]]<ref name="Nagy-Szakal, 2018" /> - [https://www.nature.com/articles/s41598-018-28477-9.pdf (Full Text)] | *2018, Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive [[metabolomics]]<ref name="Nagy-Szakal, 2018" /> - [https://www.nature.com/articles/s41598-018-28477-9.pdf (Full Text)] | ||
*2018, Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA methylation patterns<ref>{{Cite journal|last=Trivedi|first=Malav S.|last2=Oltra|first2=Elisa| | *2018, Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA methylation patterns<ref name="Trivedi2018">{{Cite journal | last = Trivedi | first = Malav S. | last2 = Oltra | first2 = Elisa | authorlink2 = Elisa Oltra | last3 = Sarria | first3 = Leonor | last4 = Rose | first4 = Natasha | last5 = Beljanski | first5 = Vladimir | last6 = Fletcher | first6 = Mary Ann | authorlink6 = Mary Ann Fletcher | last7 = Klimas | first7 = Nancy G. | authorlink7 = Nancy Klimas | last8 = Nathanson | first8 = Lubov | authorlink8 = Lubov Nathanson | date = Jul 2018 | title = Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA methylation patterns|url=http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201066|journal=PlosOne|volume=|pages=|doi=10.1371/journal.pone.0201066|via=}}</ref> - [[pubmed:30036399|(Full Text)]] | ||
*2019, From [[Diagnostic biomarker|biomarkers]] to targeted treatment: The myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and gulf war illness (GWI) story<ref>{{Cite journal|last=Klimas|first=N.G.| | *2019, From [[Diagnostic biomarker|biomarkers]] to targeted treatment: The myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and gulf war illness (GWI) story<ref name="Klimas2019">{{Cite journal | last = Klimas | first = N.G. | authorlink = Nancy Klimas | last2 = Fletcher | first2 = M.A. | authorlink2 = Mary Ann Fletcher | last3 = Abreu | first3 = M.M. | authorlink3 = | last4 = Aenlle | first4 = K. | authorlink4 = | last5 = Craddock | first5 = T. | authorlink5 = Travis Craddock | last6 = Broderick | first6 = G. | authorlink6 = Gordon Broderick | date = Feb 2019 | title = From biomarkers to targeted treatment: The myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and gulf war illness (GWI) story|url=https://linkinghub.elsevier.com/retrieve/pii/S0889159118311413|journal=Brain, Behavior, and Immunity|language=en|volume=76|issue=| pages = e40|doi=10.1016/j.bbi.2018.11.301|quote=|via=}}</ref> | ||
*2019, Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome<ref>{{Cite journal|last=Morris|first=Matthew C.| | *2019, Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome<ref name="Morris2019">{{Cite journal | last = Morris | first = Matthew C. | authorlink = Matthew Morris | last10 = Fletcher | first10 = Mary Ann | authorlink10 = Mary Ann Fletcher | last2 = Cooney | first2 = Katherine E. | authorlink2 = | last3 = Sedghamiz | first3 = Hooman | author-link3 = | last4 = Abreu | first4 = Maria | authorlink4 = | last5 = Collado | first5 = Fanny | authorlink5 = | last6 = Balbin | first6 = Elizabeth G. | authorlink6 = Elizabeth Balbin | last7 = Craddock | first7 = Travis J.A. | authorlink7 = Travis Craddock | last8 = Klimas | first8 = Nancy G. | authorlink8 = Nancy Klimas | last9 = Broderick | first9 = Gordon | authorlink9 = Gordon Broderick | date = Mar 2019 | title = Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome|url=https://linkinghub.elsevier.com/retrieve/pii/S0149291819301122|journal=Clinical Therapeutics|language=en|volume=|issue=|pages=|doi=10.1016/j.clinthera.2019.03.002|quote=|via=}}</ref> - [https://www.sciencedirect.com/science/article/abs/pii/S0149291819301122?via%3Dihub (Abstract)] | ||
*2019, Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary<ref>{{Cite journal|last=Richman|first=Spencer| | *2019, Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary<ref>{{Cite journal | last = Richman | first = Spencer | authorlink = | last2 = Morris | first2 = Matthew C. | authorlink2 = Matthew Morris | last3 = Broderick | first3 = Gordon | author-link3 = Gordon Broderick | last4 = Craddock | first4 = Travis J.A. | authorlink4 = Travis Craddock | last5 = Klimas | first5 = Nancy G. | authorlink5 = Nancy Klimas | last6 = Fletcher | first6 = Mary Ann | date = Mar 2019 | title = Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary|url=https://linkinghub.elsevier.com/retrieve/pii/S0149291819300712|journal=Clinical Therapeutics|language=en|volume=|issue=|pages=|doi=10.1016/j.clinthera.2019.02.011|quote=|via= | authorlink6 = Mary Ann Fletcher}}</ref> - [[pubmed:30871727|(Abstract)]] | ||
*2019, Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of [[Gene expression|Gene-expression]] Modules<ref>{{Cite journal|last=Jeffrey|first=Mary G.| | *2019, Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of [[Gene expression|Gene-expression]] Modules<ref name="Jeffrey2019">{{Cite journal | last= Jeffrey | first = Mary G. | authorlink = | last2 = Nathanson | first2 = Lubov | authorlink2 = Lubov Nathanson | last3 = Aenlle | first3 = Kristina | authorlink3 = | last4 = Barnes | first4 = Zachary M. | authorlink4 = Zachary Barnes | last5 = Baig | first5 = Mirza | authorlink5 = | last6 = Broderick | first6 = Gordon | authorlink6 = Gordon Broderick | last7 = Klimas | first7 = Nancy G. | authorlink7 = Nancy Klimas | last8 = Fletcher | first8 = Mary Ann | authorlink8 = Mary Ann Fletcher | last9 = Craddock | first9 = Travis J.A. | authorlink9 = Travis Craddock | date = Mar 2019 | title = Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of Gene-expression Modules|url=https://linkinghub.elsevier.com/retrieve/pii/S0149291819300475|journal=Clinical Therapeutics|language=en|volume=|issue=|pages=|doi=10.1016/j.clinthera.2019.01.011|quote=|via=}}</ref> - [[pubmed:30851951|(Abstract)]] | ||
*2019, Genetic Predisposition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study<ref>{{Cite journal|last=Perez|first=Melanie| | *2019, Genetic Predisposition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study<ref name="Perez2019">{{Cite journal | last = Perez | first = Melanie | authorlink = | last2 = Jaundoo | first2 = Rajeev | authorlink2 = | last3 = Hilton | first3 = Kelly | authorlink3 = | last4 = Del Alamo | first4 = Ana | authorlink4 = Ana Del Alamo | last5 = Gemayel | first5 = Kristina | authorlink5 = | last6 = Klimas | first6 = Nancy G. | authorlink6 = Nancy Klimas | last7 = Craddock | first7 = Travis J. | authorlink7 = Travis Craddock | last8 = Nathanson | first8 = Lubov | authorlink8 = Lubov Nathanson | date = May 2019 | title = Genetic Predisposition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study|url=https://www.frontiersin.org/articles/10.3389/fped.2019.00206/abstract|journal=Frontiers in Pediatrics|volume=7|issue=|pages=206|doi=10.3389/fped.2019.00206|quote=|via=}}</ref> - [https://www.frontiersin.org/articles/10.3389/fped.2019.00206/abstract (Abstract)] | ||
* 2019, Relationship satisfaction, communication self-efficacy, and chronic fatigue syndrome-related fatigue<ref>{{Cite journal|last=Milrad|first=Sara F.| | * 2019, Relationship satisfaction, communication self-efficacy, and chronic fatigue syndrome-related fatigue<ref name="MilradHall2019">{{Cite journal | last = Milrad | first = Sara F. | authorlink = | last2 = Hall | first2 = Daniel L. | authorlink2 = | last3 = Jutagir | first3 = Devika R. | authorlink3 = | last4 = Lattie | first4 = Emily G. | authorlink4 = | last5 = Czaja | first5 = Sara J. | authorlink5 = | last6 = Perdomo | first6 = Dolores M. | authorlink6 = | last7 = Ironson | first7 = Gail | last8 = Doss | first8 = Brian D. | last9 = Mendez | first9 = Armando | last10 = Fletcher | first10 = Mary Ann | authorlink10 = Mary Ann Fletcher | last11 = Klimas | first11 = Nancy | authorlink11 = Nancy Klimas | last12 = Antoni | first12 = Michael H. | authorlink12 = Michael Antoni | date = Jul 2019 | title = Relationship satisfaction, communication self-efficacy, and chronic fatigue syndrome-related fatigue|url=https://linkinghub.elsevier.com/retrieve/pii/S0277953619303776|journal=Social Science & Medicine|language=en|volume=|issue=|pages=112392|doi=10.1016/j.socscimed.2019.112392|quote=|via=}}</ref> - [https://www.sciencedirect.com/science/article/abs/pii/S0277953619303776 (Abstract)] | ||
*2020, Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender‐specific changes in the microRNA expression profiling in ME/CFS<ref name="Cheema2020">{{Cite journal | last = Cheema | first = Amanpreet K. | authorlink = | last2 = Sarria | first2 = Leonor | authorlink2 = | last3 = Bekheit | first3 = Mina | authorlink3 = | last4 = Collado | first4 = Fanny | authorlink4 = Fanny Collado | last5 = Almenar‐Pérez | first5 = Eloy | authorlink5 = | last6 = Martín‐Martínez | first6 = Eva | authorlink6 = | last7 = Alegre | first7 = Jose | authorlink7 = José Alegre | last8 = Castro‐Marrero | first8 = Jesus | authorlink8 = Jesús Castro-Marrero | last9 = Fletcher | first9 = Mary A. | authorlink9 = Mary Ann Fletcher | date = Apr 14, 2020 | title = Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender-specific changes in the microRNA expression profiling in ME/CFS|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.15260|journal=Journal of Cellular and Molecular Medicine|language=en|volume=00|issue=|pages=1-13|doi=10.1111/jcmm.15260|issn=1582-4934|pmc=|pmid=32291908|access-date=|quote=|via= | last10 = Klimas | first10 = Nancy | authorlink10 = Nancy Klimas | last11 = Oltra | first11 = Elisa | authorlink11 = Elisa Oltra | last12 = Nathanson | first12 = Lubov | authorlink12 = Lubov Nathanson}}</ref> - [https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.15260 (Full text)] | |||
*2020, Using Plasma Autoantibodies of Central Nervous System Proteins to Distinguish Veterans with [[Gulf War Illness]] from Healthy and Symptomatic Controls<ref>{{Cite journal | last = Abou-Donia | first = Mohamed B. | last2 = Lapadula | first2 = Elizabeth S. | last3 = Krengel | first3 = Maxine H. | last4 = Quinn | first4 = Emily | last5 = LeClair | first5 = Jessica | last6 = Massaro | first6 = Joseph | last7 = Conboy | first7 = Lisa A. | last8 = Kokkotou | first8 = Efi | last9 = Abreu | first9 = Maria | date = 2020-09-05 | title = Using Plasma Autoantibodies of Central Nervous System Proteins to Distinguish Veterans with Gulf War Illness from Healthy and Symptomatic Controls|url=https://www.mdpi.com/2076-3425/10/9/610|journal=Brain Sciences|language=en|volume=10|issue=9 | pages = 610|doi=10.3390/brainsci10090610|issn=2076-3425}}</ref> - [https://www.mdpi.com/2076-3425/10/9/610/htm (Full text)] | |||
==Talks and interviews== | ==Talks and interviews== | ||
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*[http://www.nbcdfw.com/news/health/Tired-Of-Chronic-Fatigue-404085946.html Dec 1, 2016 NBCDFW video interview and transcription] | *[http://www.nbcdfw.com/news/health/Tired-Of-Chronic-Fatigue-404085946.html Dec 1, 2016 NBCDFW video interview and transcription] | ||
*[https://www.youtube.com/watch?v=v0gm5gwM5aU&feature=em-subs_digest Dec 2, 2016, Episode 84 of] [[ME/CFS Alert]] - Dr Nancy Klimas on ME/CFS Research, Treatment | *[https://www.youtube.com/watch?v=v0gm5gwM5aU&feature=em-subs_digest Dec 2, 2016, Episode 84 of] [[ME/CFS Alert]] - Dr Nancy Klimas on ME/CFS Research, Treatment | ||
*2 | *Jun 2, 2017, Speaker at the 12th [[Invest in ME International ME Conference]]; Speech title: ''Genetic Signature Study''<ref>http://www.investinme.org/iimec12.shtml</ref> - [https://www.youtube.com/watch?v=Uh7hxwpJWlI (Video)] | ||
*13 | *Sept 13, 2017, [https://www.cfs-me-network.com/2017/09/13/interview-nancy-klimas-cfs/ Interview with CFS/ME researcher Dr. Nancy Klimas] conducted by Zach Elwood | ||
*May 31, 2019, Speaker at the 14th [[Invest in ME International ME Conference]]; Speech title: ''Integrative Medicine Approach to Treatment of ME''<ref>{{Cite web|url=http://www.investinme.org/IIMEC14.shtml | title = Invest in ME Research - IIMEC14 14th Invest in ME Reseaerch International ME Conference 2019 | website = [[Invest in ME Research]]|access-date=2020-02-25}}</ref> ''-'' [https://www.youtube.com/watch?v=VOpLORv4GgE (Video)] | |||
==Quotations== | ==Quotations== | ||
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===Open Letter to ''The Lancet''=== | ===Open Letter to ''The Lancet''=== | ||
Two [[open letter to the Lancet | open letters to the editor of ''The Lancet'']] urged the editor to commission a fully independent review of the [[PACE trial]], which the journal had published in 2011. In 2016, Dr. Klimas, along with 41 colleagues in the | Two [[open letter to the Lancet | open letters to the editor of ''The Lancet'']] urged the editor to commission a fully independent review of the [[PACE trial]], which the journal had published in 2011. In 2016, Dr. Klimas, along with 41 colleagues in the ME/CFS field, signed the second letter. | ||
*10 February 2016, [http://www.virology.ws/2016/02/10/open-letter-lancet-again/ An open letter to The Lancet, again - Virology blog] | *10 February 2016, [http://www.virology.ws/2016/02/10/open-letter-lancet-again/ An open letter to The Lancet, again - Virology blog] | ||
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==References== | ==References== | ||
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| last8 | <ref name="Nagy-Szakal, 2017">{{Citation | last1 = Nagy-Szakal | first1 = Dorottya | authorlink1 = Dorottya Nagy-Szakal | last2 = Williams | first2 = Brent L. | authorlink2 = | last3 = Mishra | first3 = Nischay | authorlink3 = | last4 = Che | first4 = Xiaoyu | authorlink4 = | last5 = Lee | first5 = Bohyun | authorlink5 = | last6 = Bateman | first6 = Lucinda | authorlink6 = Lucinda Bateman | last7 = Klimas | first7 = Nancy G. | authorlink7 = Nancy Klimas | last8 = Komaroff | first8 = Anthony L. | authorlink8 = Anthony Komaroff | last9 = Levine | first9 = Susan | authorlink9 = Susan Levine | last10 = Montoya | first10 = Jose G. | authorlink10 = Jose Montoya | last11 =Peterson | first11 = Daniel L. | authorlink11 = Daniel Peterson | last12 = Ramanan | first12 = Devi | authorlink12 = | last13 = Jain | first13 = Komal | authorlink13 = | last14 = Eddy | first14 = Meredith L. | authorlink14 = | last15 = Hornig | first15 = Mady | authorlink15 = Mady Hornig | last16 = Lipkin | first16 = W. Ian | authorlink16 = Ian Lipkin | title = Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome | journal = Microbiome | volume = 5 | issue = 44 | page = | date = 2017 | pmid = | doi = 10.1186/s40168-017-0261-y }}</ref> | ||
| title | <ref name="Nagy-Szakal, 2018">{{Citation | last1 = Nagy-Szakal | first1 = Dorottya | authorlink1 = Dorottya Nagy-Szakal | last2 = Barupal | first2 = Dinesh K. | authorlink2 = | last3 = Lee | first3 = Bohyun | authorlink3 = | last4 = Che | first4 = Xiaoyu | authorlink4 = | last5 = Williams | first5 = Brent L. | authorlink5 = | last6 = Kahn | first6 = Ellie J. R. | authorlink6 = | last7 =Ukaigwe | first7 = Joy E. | authorlink7 = | last8 = Bateman | first8 = Lucinda | authorlink8 = Lucinda Bateman | last9 = Klimas | first9 = Nancy G. | authorlink9 = Nancy Klimas | last10 = Komaroff | first10 = Anthony L. | authorlink10 = Anthony Komaroff | last11 = Levine | first11 = Susan | authorlink11 = Susan Levine | last12 = Montoya | first12 = Jose G. | authorlink12 = Jose Montoya | last13 = Peterson | first13 = Daniel L. | authorlink13 = Daniel Peterson | last14 = Levin | first14 = Bruce | authorlink14 = Bruce Levin | last15 = Hornig | first15 = Mady| authorlink15 = Mady Hornig | last16 = Fiehn | first16 = Oliver | authorlink16 = | last17 = Lipkin | first17 = W. Ian | authorlink17 = Ian Lipkin | title = Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics | journal = Scientific Reports | volume = 8 | issue = 1 | page = 10056 | date = 2018 | pmid = | doi = 10.1038/s41598-018-28477-9 }}</ref> | ||
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Latest revision as of 14:04, July 25, 2023
Nancy G. Klimas, MD, is an American researcher and physician who is the Director at the Institute for Neuro Immune Medicine at Nova Southeastern University in Miami and Ft. Lauderdale, Florida. She is, also: Director of Clinical Immunology Research, Miami VAMC; Professor of Medicine, Department of Clinical Immunology, College of Osteopathic Medicine, Nova Southeastern University; Chair, Department of Clinical Immunology, College of Osteopathic Medicine, Nova Southeastern University; and Professor Emerita, University of Miami, School of Medicine.[1]
Awards[edit | edit source]
- 2011, Nelson Gantz Outstanding Clinician Award awarded to a physician who emulates Nelson Gantz's clinical acumen, his passion for medicine, and his empathy for persons with CFS/FM awarded by IACFS/ME[2]
- 2014, Rudy Perpich Senior Lectureship Award, presented to a distinguished CFS/FMS scientist, physician or healthcare worker awarded by IACFS/ME.[2]
Committees[edit | edit source]
2015 Institute of Medicine report[edit | edit source]
- Dr. Klimas was one of the ME/CFS experts on the "Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome" that was convened to produce the 2015 Institute of Medicine report.[3]
Case definition authorships[edit | edit source]
- Klimas is one of the authors of the 2011 case definition, International Consensus Criteria,[4] the 2006 Pediatric Case Definition for Myalgic Encephalomyelitis and Chronic Fatigue Syndrome[5], as well as, one of the authors of the 2003 Canadian Consensus Criteria for ME/CFS, published as Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols[6]
Chronic Fatigue Syndrome Advisory Committee[edit | edit source]
- Dr. Klimas served as a voting member of the Chronic Fatigue Syndrome Advisory Committee for the U.S. Department of Health and Human Services from April 1, 2007 to April 1, 2011.[7]
International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[edit | edit source]
- Dr. Klimas served as past President of the Board of Directors of the International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (IACFS/ME) from 2004-2009.[8] She has been awarded the IACFS/ME Nelson Gantz Outstanding Clinician Award (in 2011) and the IACFS/ME Rudy Perpich Senior Lectureship Award (in 2014).[2]
- Dr. Klimas serves on the editorial board of the journal, Fatigue: Biomedicine, Health & Behavior, published on behalf of the IACFS/ME.[9]
ME/CFS Common Data Elements (CDE) Project[edit | edit source]
- Co-chair of the Immune Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke and the Centers for Disease Control and Prevention.[10]
ME/CFS Gene Study[edit | edit source]
Nancy Klimas is part of the Institute for Neuroimmune Medicine's ME/CFS Gene Study, which aims to "create a one of a kind genetic database for ME/CFS."[11] The ME/CFS Gene Study is a worldwide internet-based study that asks for either people with ME/CFS or Healthy Controls to submit gene information they have acquired themselves. Participants answer a questionnaire to check they can take part, then arrange their own gene testing through 23andMe or Ancestry DNA, which need saliva samples to be sent by post. They then send the results electronically to the study group.[11]
Research studies[edit | edit source]
Earlier studies[edit | edit source]
For earlier studies: Research studies of Nancy Klimas
Recent studies[edit | edit source]
- 2016, Poor sleep quality is associated with greater circulating pro-inflammatory cytokines and severity and frequency of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) symptoms in women[12] - (Abstract)
- 2016, Illness progression in chronic fatigue syndrome: a shifting immune baseline[13] -(Full Text)
- 2016, Tracking post-infectious fatigue in clinic using routine Lab tests[14] - (Full Text)
- 2016, Gastric Enterovirus Infection: A Possible Causative Etiology of Gastroparesis[15] - (Abstract)
- 2017, Depression, evening salivary cortisol and inflammation in chronic fatigue syndrome: A psychoneuroendocrinological structural regression model[16] - (Abstract)
- 2017, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Gulf War Illness patients exhibit increased humoral responses to the Herpesviruses-encoded dUTPase: Implications in disease pathophysiology: Herpesviruses in ME/CFS and Gulf War Illness[17] - (Abstract)
- 2017, Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome[18] - (Full Text)
- 2017, Multi-Site Clinical Assessment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (MCAM): Design and Implementation of a Prospective/Retrospective Rolling Cohort Study[19] - (Abstract)
- 2017, Telephone-administered versus live group cognitive behavioral stress management for adults with CFS[20] - (Full Text)
- 2018, KPAX002 as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A prospective, randomized trial[21] - (Full Text)
- 2018, Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics[22] - (Full Text)
- 2018, Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA methylation patterns[23] - (Full Text)
- 2019, From biomarkers to targeted treatment: The myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and gulf war illness (GWI) story[24]
- 2019, Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome[25] - (Abstract)
- 2019, Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary[26] - (Abstract)
- 2019, Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of Gene-expression Modules[27] - (Abstract)
- 2019, Genetic Predisposition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study[28] - (Abstract)
- 2019, Relationship satisfaction, communication self-efficacy, and chronic fatigue syndrome-related fatigue[29] - (Abstract)
- 2020, Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender‐specific changes in the microRNA expression profiling in ME/CFS[30] - (Full text)
- 2020, Using Plasma Autoantibodies of Central Nervous System Proteins to Distinguish Veterans with Gulf War Illness from Healthy and Symptomatic Controls[31] - (Full text)
Talks and interviews[edit | edit source]
There are many videos on YouTube of Nancy Klimas speaking about her work.[32]
- 2009 Readers Ask: A Virus Linked to Chronic Fatigue Syndrome
- From Bedside to Bench and Back Again: Untangling the Mystery of Gulf War Illness and Chronic Fatigue Syndrome
- 2011 ME/CFS Management A Pathogenesis Based Approach (sponsored by ANZMES)
- ME/CFS and Exercise: VO2 Max Testing with Nancy Klimas M.D. PREVIEW
- 2014 ME/CFS Diagnosis and Name with Dr. Nancy Klimas
- 2014 ME/CFS Treatment Options Part 1 with Dr. Nancy Klimas
- 2014 ME/CFS Treatment Options Part 2 with Dr. Nancy Klimas
- Dec 1, 2016 NBCDFW video interview and transcription
- Dec 2, 2016, Episode 84 of ME/CFS Alert - Dr Nancy Klimas on ME/CFS Research, Treatment
- Jun 2, 2017, Speaker at the 12th Invest in ME International ME Conference; Speech title: Genetic Signature Study[33] - (Video)
- Sept 13, 2017, Interview with CFS/ME researcher Dr. Nancy Klimas conducted by Zach Elwood
- May 31, 2019, Speaker at the 14th Invest in ME International ME Conference; Speech title: Integrative Medicine Approach to Treatment of ME[34] - (Video)
Quotations[edit | edit source]
- "They experience a level of disability equal to that of patients with late-stage AIDS and patients undergoing chemotherapy"[35]
- "I split my clinical time between the two illnesses, and I can tell you if I had to choose between the two illnesses (in 2009) I would rather have H.I.V."[36]
Advocacy[edit | edit source]
Open Letter to The Lancet[edit | edit source]
Two open letters to the editor of The Lancet urged the editor to commission a fully independent review of the PACE trial, which the journal had published in 2011. In 2016, Dr. Klimas, along with 41 colleagues in the ME/CFS field, signed the second letter.
- 10 February 2016, An open letter to The Lancet, again - Virology blog
Online presence[edit | edit source]
Learn more[edit | edit source]
See also[edit | edit source]
- Dr. Gordon Broderick
- Dr. Mary Ann Fletcher
- Dr. Irma Rey
- Dr. Maria Vera
- Institute for Neuro Immune Medicine
- Research studies of Nancy Klimas
References[edit | edit source]
- ↑ http://www.nova.edu/nim/clinic/dr.-nancy-klimas-bio-page.html
- ↑ 2.0 2.1 2.2 International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis"IACFS/ME Awardees". IACFS/ME. Retrieved April 23, 2020.
- ↑ Clayton, Ellen Wright; Alegria, Margarita; Bateman, Lucinda; Chu, Lily; Cleeland, Charles; Davis, Ronald; Diamond, Betty; Ganiats, Theodore; Keller, Betsy; Klimas, Nancy; Lerner, A Martin; Mulrow, Cynthia; Natelson, Benjamin; Rowe, Peter; Shelanski, Michael (2015). "Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Redefining an Illness" (PDF). National Academies.
- ↑ Carruthers, Bruce M.; van de Sande, Marjorie I.; De Meirleir, Kenny L.; Klimas, Nancy G.; Broderick, Gordon; Mitchell, Terry; Staines, Donald; Powles, A.C. Peter; Speight, Nigel; Vallings, Rosamund; Bateman, Lucinda; Baumgarten-Austrheim, Barbara; Bell, David; Carlo-Stella, Nicoletta; Chia, John; Darragh, Austin; Jo, Daehyun; Lewis, Donald; Light, Alan; Marshall-Gradisnik, Sonya; Mena, Ismael; Mikovits, Judy; Miwa, Kunihisa; Murovska, Modra; Pall, Martin; Stevens, Staci (August 22, 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327–338. doi:10.1111/j.1365-2796.2011.02428.x. ISSN 0954-6820. PMC 3427890. PMID 21777306.
- ↑ Jason, Leonard A; Jordan, Karen; Miike, Teruhisa; Bell, David S; Lapp, Charles; Torres-Harding, Susan; Rowe, Kathy; Gurwitt, Alan; De Meirleir, Kenny; Van Hoof, Elke LS (2006), "A Pediatric Case Definition for Myalgic Encephalomyelitis and Chronic Fatigue Syndrome", Journal of Chronic Fatigue Syndrome, 13 (2–3): 1–44, doi:10.1300/J092v13n02_01
- ↑ Carruthers, Bruce M.; Jain, Anil Kumar; De Meirleir, Kenny L.; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison C.; Flor-Henry, Pierre; Joshi, Pradip; Powles, AC Peter; Sherkey, Jeffrey A.; van de Sande, Marjorie I. (2003). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols" (PDF). Journal of Chronic Fatigue Syndrome. 11 (2): 7–115. doi:10.1300/J092v11n01_02.
- ↑ http://nih.granicus.com/DocumentViewer.php?file=nih_e174f9bd-ae0f-4a45-9955-827cb608db2f.pdf
- ↑ http://iacfsme.org/Organization/Committees-of-the-IACFS-ME.aspx
- ↑ "Fatigue: Biomedicine, Health & Behavior". Taylor and Francis Online. Retrieved November 1, 2019.
- ↑ "Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster". NIH. Retrieved October 11, 2019.
- ↑ 11.0 11.1 Nova Southeastern University. "ME/CFS Genes Study | NSU Institute for Neuro Immune Medicine". NSU. Retrieved November 1, 2018.
- ↑ Milrad, Sara F.; Hall, Daniel L.; Jutagir, Devika R.; Lattie, Emily G.; Ironson, Gail H.; Wohlgemuth, William; Vera Nunez, Maria; Garcia, Lina; Czaja, Sara J.; Perdomo, Dolores M.; Fletcher, Mary Ann; Klimas, Nancy; Antoni, Michael H. (2016). "Poor sleep quality is associated with greater circulating pro-inflammatory cytokines and severity and frequency of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) symptoms in women". Journal of Neuroimmunology. 0 (0). doi:10.1016/j.jneuroim.2016.12.008.
- ↑ Russell, Lindsey; Broderick, Gordon; Taylor, Renee; Fernandes, Henrique; Harvey, Jeanna; Barnes, Zachary; Smylie, AnneLiese; Collado, Fanny; Balbin, Elizabeth; Katz, Ben; Klimas, Nancy; Fletcher, Mary Ann (2016), "Illness progression in chronic fatigue syndrome: a shifting immune baseline", BMC Immunology, doi:10.1186/s12865-016-0142-3
- ↑ Harvey, Jeanna M.; Broderick, Gordon; Bowie, Alanna; Barnes, Zachary M.; Katz, Ben Z.; O'Gorman, Maurice R.G.; Vernon, Suzanne D.; Fletcher, Mary Ann; Klimas, Nancy G. (April 26, 2016). "Tracking post-infectious fatigue in clinic using routine Lab tests". BMC Pediatrics. 15: 54. doi:10.1186/s12887-016-0596-8. ISSN 1471-2431. PMC 4847210. PMID 27118537.
- ↑ Barkin, JA; Czul, F; Barkin, JS; Klimas, NG; Rey, IR; Moshiree, B (2016). "Gastric Enterovirus Infection: A Possible Causative Etiology of Gastroparesis". Digestive Diseases and Sciences. 61 (8): 2344-50. doi:10.1007/s10620-016-4227-x. PMID 27344315.
- ↑ Milrad, Sara F.; Hall, Daniel L.; Jutagir, Devika R.; Lattie, Emily G.; Czaja, Sara J.; Perdomo, Dolores M.; Fletcher, Mary Ann; Klimas, Nancy; Antoni, Michael H. (2017). "Depression, evening salivary cortisol and inflammation in chronic fatigue syndrome: A psychoneuroendocrinological structural regression model". Int J Psychophysiol. 0 (0). doi:10.1016/j.ijpsycho.2017.09.009.
- ↑ Halpin, P; Williams, MV; Klimas, NG; Fletcher, MA; Barnes, Zachary; Ariza, ME (2017), "Myalgic encephalomyelitis/chronic fatigue syndrome and gulf war illness patients exhibit increased humoral responses to the herpesviruses-encoded dUTPase: Implications in disease pathophysiology", Journal of Medical Virology, doi:10.1002/jmv.24810, PMID 28303641
- ↑ Nagy-Szakal, Dorottya; Williams, Brent L.; Mishra, Nischay; Che, Xiaoyu; Lee, Bohyun; Bateman, Lucinda; Klimas, Nancy G.; Komaroff, Anthony L.; Levine, Susan; Montoya, Jose G.; Peterson, Daniel L.; Ramanan, Devi; Jain, Komal; Eddy, Meredith L.; Hornig, Mady; Lipkin, W. Ian (2017), "Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome", Microbiome, 5 (44), doi:10.1186/s40168-017-0261-y
- ↑ Unger, Elizabeth R.; Lin, Jin-Mann S.; Tian, Hao; Natelson, Benjamin H; Lange, Gudrun; Vu, Diana; Blate, Michelle; Klimas, Nancy G.; Balbin, Elizabeth G.; Bateman, Lucinda; Allen, Ali; Lapp, Charles W.; Springs, Wendy; Kogelnik, Andreas M.; Phan, Catrina C.; Danver, Joan; Podell, Richard N.; Fitzpatrick, Trisha; Peterson, Daniel L.; Gottschalk, C. Gunnar; Rajeevan, Mangalathu S.; MCAM Study Group (2017), "Multi-Site Clinical Assessment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (MCAM): Design and Implementation of a Prospective/Retrospective Rolling Cohort Study.", American Journal of Epidemiology, 1–10, doi:10.1093/aje/kwx029
- ↑ Hall, DL; Lattie, EG; Milrad, SF; Czaja, S; Fletcher, MA; Klimas, N; Perdomo, D; Antoni, MH (2017), "Telephone-administered versus live group cognitive behavioral stress management for adults with CFS", J Psychosom Res, 93: 41-47, doi:10.1016/j.jpsychores.2016.12.004
- ↑ Montoya, Jose G; Anderson, Jill N; Adolphs, Danya L; Bateman, Lucinda; Klimas, Nancy; Levine, Susan M; Garvert, Donn W; Kaiser, Jon D (2018), "KPAX002 as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A prospective, randomized trial" (PDF), International Journal of Clinical and Experimental Medicine, 11 (3): 2890-2900
- ↑ Nagy-Szakal, Dorottya; Barupal, Dinesh K.; Lee, Bohyun; Che, Xiaoyu; Williams, Brent L.; Kahn, Ellie J. R.; Ukaigwe, Joy E.; Bateman, Lucinda; Klimas, Nancy G.; Komaroff, Anthony L.; Levine, Susan; Montoya, Jose G.; Peterson, Daniel L.; Levin, Bruce; Hornig, Mady; Fiehn, Oliver; Lipkin, W. Ian (2018), "Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics", Scientific Reports, 8 (1): 10056, doi:10.1038/s41598-018-28477-9
- ↑ Trivedi, Malav S.; Oltra, Elisa; Sarria, Leonor; Rose, Natasha; Beljanski, Vladimir; Fletcher, Mary Ann; Klimas, Nancy G.; Nathanson, Lubov (July 2018). "Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA methylation patterns". PlosOne. doi:10.1371/journal.pone.0201066.
- ↑ Klimas, N.G.; Fletcher, M.A.; Abreu, M.M.; Aenlle, K.; Craddock, T.; Broderick, G. (February 2019). "From biomarkers to targeted treatment: The myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and gulf war illness (GWI) story". Brain, Behavior, and Immunity. 76: e40. doi:10.1016/j.bbi.2018.11.301.
- ↑ Morris, Matthew C.; Cooney, Katherine E.; Sedghamiz, Hooman; Abreu, Maria; Collado, Fanny; Balbin, Elizabeth G.; Craddock, Travis J.A.; Klimas, Nancy G.; Broderick, Gordon; Fletcher, Mary Ann (March 2019). "Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome". Clinical Therapeutics. doi:10.1016/j.clinthera.2019.03.002.
- ↑ Richman, Spencer; Morris, Matthew C.; Broderick, Gordon; Craddock, Travis J.A.; Klimas, Nancy G.; Fletcher, Mary Ann (March 2019). "Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary". Clinical Therapeutics. doi:10.1016/j.clinthera.2019.02.011.
- ↑ Jeffrey, Mary G.; Nathanson, Lubov; Aenlle, Kristina; Barnes, Zachary M.; Baig, Mirza; Broderick, Gordon; Klimas, Nancy G.; Fletcher, Mary Ann; Craddock, Travis J.A. (March 2019). "Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of Gene-expression Modules". Clinical Therapeutics. doi:10.1016/j.clinthera.2019.01.011.
- ↑ Perez, Melanie; Jaundoo, Rajeev; Hilton, Kelly; Del Alamo, Ana; Gemayel, Kristina; Klimas, Nancy G.; Craddock, Travis J.; Nathanson, Lubov (May 2019). "Genetic Predisposition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study". Frontiers in Pediatrics. 7: 206. doi:10.3389/fped.2019.00206.
- ↑ Milrad, Sara F.; Hall, Daniel L.; Jutagir, Devika R.; Lattie, Emily G.; Czaja, Sara J.; Perdomo, Dolores M.; Ironson, Gail; Doss, Brian D.; Mendez, Armando; Fletcher, Mary Ann; Klimas, Nancy; Antoni, Michael H. (July 2019). "Relationship satisfaction, communication self-efficacy, and chronic fatigue syndrome-related fatigue". Social Science & Medicine: 112392. doi:10.1016/j.socscimed.2019.112392.
- ↑ Cheema, Amanpreet K.; Sarria, Leonor; Bekheit, Mina; Collado, Fanny; Almenar‐Pérez, Eloy; Martín‐Martínez, Eva; Alegre, Jose; Castro‐Marrero, Jesus; Fletcher, Mary A.; Klimas, Nancy; Oltra, Elisa; Nathanson, Lubov (April 14, 2020). "Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender-specific changes in the microRNA expression profiling in ME/CFS". Journal of Cellular and Molecular Medicine. 00: 1–13. doi:10.1111/jcmm.15260. ISSN 1582-4934. PMID 32291908.
- ↑ Abou-Donia, Mohamed B.; Lapadula, Elizabeth S.; Krengel, Maxine H.; Quinn, Emily; LeClair, Jessica; Massaro, Joseph; Conboy, Lisa A.; Kokkotou, Efi; Abreu, Maria (September 5, 2020). "Using Plasma Autoantibodies of Central Nervous System Proteins to Distinguish Veterans with Gulf War Illness from Healthy and Symptomatic Controls". Brain Sciences. 10 (9): 610. doi:10.3390/brainsci10090610. ISSN 2076-3425.
- ↑ YouTube - nancy klimas
- ↑ http://www.investinme.org/iimec12.shtml
- ↑ "Invest in ME Research - IIMEC14 14th Invest in ME Reseaerch International ME Conference 2019". Invest in ME Research. Retrieved February 25, 2020.
- ↑ University of Miami ME/CFS Researcher Nancy Klimas, MD, Explains Complexity of Chronic Fatigue Syndrome in Terms That Anybody Can Understand
- ↑ Readers Ask: A Virus Linked to Chronic Fatigue Syndrome
