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NTRK
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{{stub}} '''Neurotrophic Receptor Tyrosine Kinase''' or '''NTRK''' is a superfamily of receptor tyrosine kinases<ref name="Thiriet2011">{{Cite book | title = Signaling at the Cell Surface in the Circulatory and Ventilatory Systems | pages = 648|isbn=978-1-4614-1991-4|edition=|volume=|language=en|title-link=|url=https://books.google.co.uk/books?id=MF_kmIWZRrMC&lpg=PA654&dq=NTRK%20Neurotrophic%20receptor%20tyrosine%20kinase&pg=PA654#v=onepage&q=NTRK%20Neurotrophic%20receptor%20tyrosine%20kinase&f=true|access-date= | date = 2011-12-14|publisher=Springer Science & Business Media | last = Thiriet | first = Marc | authorlink = |veditors=|others=|doi=|oclc=|quote=|archive-url=|archive-date=|location=}}</ref> these are protein-encoding genes that may be linked to [[myalgic encephalomyelitis]]/<wbr>[[chronic fatigue syndrome]].<ref name="AlmenarPerez2020" /> ===NTRK1=== Neurotrophic Tyrosine Kinase Receptor 1 is one of the NTKR family of protein-encoding genes.<ref name="genecards">{{Cite web|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=NTRK1 | title = NTRK1 Gene {{!}} NTRK1 Protein {{!}} NTRK1 Antibody | last = GeneCards | first = | authorlink = | date = | website = genecards.org|archive-url=|archive-date=|url-status=|access-date=2020-02-12}}</ref> ==ME/CFS == Almenar-Pérez et al (2020) found that NTRK appeared to be affected in patients with severe ME/CFS, which could relate to "symptoms such as [[cognitive dysfunction |cognitive disability]] and sensorial dysfunctions (altered [[Allodynia|pain sensitivity]])<sup>44</sup>".<ref name="AlmenarPerez2020" /> In this small study of patients with [[severe and very severe ME|severe ME]], '''NTRK1''' levels were found to be significantly higher in the severely ill patients compared to healthy controls.<ref name="AlmenarPerez2020" /> == Notable studies == * Feb 7, 2020 - Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/<wbr>Chronic Fatigue Syndrome.<ref name="AlmenarPerez2020">{{Cite journal | last = Almenar-Pérez | first = Eloy | authorlink = | last2 = Sarría | first2 = Leonor | authorlink2 = | last3 = Nathanson | first3 = Lubov | authorlink3 = Lubov Nathanson | last4 = Oltra | first4 = Elisa | authorlink4 = Elisa Oltra | date = 2020-02-07 | title = Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|url=https://www.nature.com/articles/s41598-020-58506-5|journal=Scientific Reports|language=en|volume=10|issue=1|pages=1–15|doi=10.1038/s41598-020-58506-5|issn=2045-2322|pmc=|pmid=|access-date=Feb 12, 2020|quote=|via=}}</ref> ==See also == * [[Tyrosine]] * [[Diagnostic biomarker]] ==Learn more == * [https://www.genecards.org/cgi-bin/carddisp.pl?gene=NTRK1 NTRK1] - Gene cards ==References == [[Category:Genes]] [[Category:Biochemistry and cell biology]] {{Reflist}} [[Category:Enzymes]]
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