Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
N-acetylcysteine
(section)
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
==ME/CFS== In a presentation to the 2016 [[International IACFS/ME Research and Clinical Conference|IACFS/ME conference]] Dr [[Dikoma Shungu]] of Cornell University gave a presentation on a trial of NAC in [[ME/CFS]] patients.<ref name="IACFSME2016">{{Cite web|url= http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx|url-status=dead|archive-url=https://www.healthrising.org/forums/threads/nac-for-neuroinflammation-in-me-cfs-and-fibromyalgia.5046/post-26022|archive-date=2016-11-21 | title = N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy | first = N. | last= Weiduschat | first2 = X. | last2 = Mao | first3 = D. | last3 = Vub | first4 = M. | last4 = Blate | first5 = G. | last5 = Kang | first6 = H.S. | last6 = Mangat | first7 = A. | last7 = Artis | first8 = S. | last8 = Banerjee | first9 = G. | last9 = Lange | first10 = C. | last10 = Henchcliff | first11 = B.H. | last11 = Natelson | first12 = D.C. | last12 = Shungu|work=IACFS/ME Syllabus | date = 2016 | page=35}}</ref> Previously his team had found a 36% deficit of the tissue anti-oxidant occipital cortex [[glutathione]] (GSH) in the cortical areas of the brains of ME/CFS patients.<ref>[https://www.ncbi.nlm.nih.gov/pubmed/22281935 Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. Shungu et al]</ref> The trial supplemented patients (meeting the [[Fukuda criteria|CDC criteria]] for CFS) with 1800mg daily of GSH precursor n-acetylcysteine for 4 weeks and looked at levels of cortical GSH. The study found that cortical GSH had increased in patients and that CFS symptoms (as assessed with the [[Centers for Disease Control and Prevention|CDC]] CFS symptom inventory) were significantly reduced.<ref name="IACFSME2016" /> In 2020, a double-blind placebo controlled clinical trial of NAC was registered, and is due to take place at Cornell University in conjunction with [[National Institute of Neurological Disorders and Stroke|NINDS]], to measure the effects of 900mg and 3600mg of NAC compared to a placebo in ME/CFS patients.<ref name="NCT04542161">{{Cite web|url=https://clinicaltrials.gov/ct2/show/NCT04542161 | title = Assessment of N-Acetylcysteine as Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | last = | first = | authorlink = | date = |website=clinicaltrials.gov|language=en|archive-url=|archive-date=|url-status=|access-date=2020-09-11}}</ref> The trial will take part in two different locations, with the principle investigator is [[Dikoma Shungu]].<ref name="NCT04542161" /> The trial aims to measure the effect of NAC on patients with ME/CFS who have low GSH levels.<ref name="NCT04542161" />
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
This page is a member of 2 hidden categories:
Category:All articles with unsourced statements
Category:Articles with unsourced statements from 2021
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs