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Myalgic encephalomyelitis/he
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== Sex differences == [[File:Florence Nightingale.png|200px|thumb|right|[[Florence Nightingale]] was a British citizen and pioneer of modern nursing. Nightingale was stationed in Crimea when she developed "Crimean fever" (a bacterial infection now known as [[brucellosis]]) and never recovered. She remained [[Severe and very severe ME|mostly bedbound]] the rest of her life. Although ME and CFS were not defined in her lifetime, many current physicians and medical historians believe she developed ME/CFS as a result of a chronic brucellosis infection]] {{Main article |page_name = Sex differences in myalgic encephalomyelitis and chronic fatigue syndrome}} A Norwegian [[CFS/ME]] study shows that the disease affects all ages, with two peak ages of 10-19 years and 30-39 years; it is more common in women than in men.<ref>{{Cite journal | last = Bakken | first = Inger Johanne | last2 = Tveito | first2 = Kari | last3 = Gunnes | first3 = Nina | last4 = Ghaderi | first4 = Sara | last5 = Stoltenberg | first5 = Camilla | last6 = Trogstad | first6 = Lill | last7 = H åberg | first7 = Siri Eldevik | last8 = Magnus | first8 = Per | date = 2014-10-01 | title = Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008-2012|url=http://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-014-0167-5|journal=BMC Medicine|language=en|volume=12|issue=1|pages=|doi=10.1186/s12916-014-0167-5|issn=1741-7015|pmid=25274261|via=}}</ref> Research by the [[Open Medicine Foundation]] cited in its paper, [[Metabolic features of chronic fatigue syndrome|''Metabolic features of chronic fatigue syndrome'']] which studied severe [[Chronic fatigue syndrome|CFS]], found that the disease is different in men and women but this is not related to testosterone or estrogen. [[Michael VanElzakker]] notes there are [[Michael_VanElzakker#Male_and_female_differences_in_neuropathic_pain|male and female differences in neuropathic pain]]. A study of UK and Dutch cohorts found "younger children had a more equal gender balance compared to adolescents and adults."<ref>{{Cite journal | last = Collin | first = Simon M. | last2 = Nuevo | first2 = Roberto | last3 = van de Putte | first3 = Elise M. | last4 = Nijhof | first4 = Sanne L. | last5 = Crawley | first5 = Esther | date = 2015-10-28 | title = Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME) is different in children compared to in adults: a study of UK and Dutch clinical cohorts|url=https://www.ncbi.nlm.nih.gov/pubmed/26510728|journal=BMJ open|volume=5|issue=10| pages = e008830|doi=10.1136/bmjopen-2015-008830|issn=2044-6055|pmid=26510728|via=}}</ref>
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