Muscle fatigability

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Revision as of 11:09, November 30, 2022 by Notjusttired (talk | contribs) (Text replacement - ". A. | " to ".A. |")

Muscle fatigability in ME is a symptom in which muscles become weaker after minor exertion and a long period (3-5 days or longer) may elapse before full muscle power is restored. According to Melvin Ramsay, it is the defining feature of myalgic encephalomyelitis, without which a diagnosis of ME should not be made,[1] though this symptom is noted to improve during remission. Similar muscle effects are known to occur in other neurological diseases such as multiple sclerosis[2] and post-polio syndrome.[3]

Prevalence[edit | edit source]

Symptom recognition[edit | edit source]

  • In the Holmes criteria, unexplained generalized muscle weakness is an optional criteria for diagnosis, under the section Minor Symptom Criteria.[6]

Notable studies[edit | edit source]

Possible causes[edit | edit source]

  • Muscle biopsies have shown evidence of mitochondrial degeneration,[7] deletions of mitochondrial DNA,[8][9] and the reduction of mitochondrial activity.[10]
  • In addition, evidence of oxidative damage to muscles has been found in CFS.[11]
  • Studies have found reduced levels of serum carnitine which return to normal after recovery and correlate with symptom severity.[12]
  • Exercise has also been found to induce both early and excessive lactic acid formation in the muscles[13] with a reduced intraceullar concentrations of ATP and acceleration of glycolysis.[14]
  • Neurologist Peter Behan noted that ME patients were found to lack an important muscle enzyme called myoadenylate deaminase. A small peer-reviewed study found this present in only 5.5% of patients, and associated primarily with muscle pain rather than fatigue.[15] Myoadenylate deaminase has since been ruled out as the sole cause of ME/CFS.[16]

Potential treatments[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. "Ramsay's Definition of M.E., 1986". cfids-me.org. Retrieved August 28, 2019.
  2. Managing MS Symptoms - Fatigue and Fatigability
  3. "The Late Effects of Polio: An Overview". post-polio.org. Retrieved August 28, 2019.
  4. De Becker, Pascale; McGregor, Neil; De Meirleir, Kenny (December 2001). "A definition‐based analysis of symptoms in a large cohort of patients with chronic fatigue syndrome". Journal of Internal Medicine. 250 (3): 234–240. doi:10.1046/j.1365-2796.2001.00890.x.
  5. Berne, Katrina (December 1, 1995). Running on Empty: The Complete Guide to Chronic Fatigue Syndrome (CFIDS) (2nd ed.). Hunter House. p. 59. ISBN 978-0897931915.
  6. "Holmes Definition of Chronic Fatigue Syndrome, U.S. CDC 1988". cfids-me.org. Retrieved August 28, 2019.
  7. Behan, W. M. H.; More, I. A. R.; Behan, P. O. (December 1991). "Mitochondrial abnormalities in the postviral fatigue syndrome". Acta Neuropathologica. 83 (1): 61–65. doi:10.1007/BF00294431. ISSN 0001-6322. Unknown parameter |authorlinklink3= ignored (help); Cite has empty unknown parameter: |authorlinklink= (help)
  8. Vecchiet, L.; Montanari, G.; Pizzigallo, E.; Iezzi, S.; de Bigontina, P.; Dragani, L.; Vecchiet, J.; Giamberardino, M.A. (April 19, 1996). "Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome". Neuroscience Letters. 208 (2): 117–120. doi:10.1016/0304-3940(96)12559-3. ISSN 0304-3940. PMID 8859904.
  9. Zhang, C.; Baumer, A.; Mackay, I.R.; Linnane, A. W.; Nagley, P. (April 1995). "Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome". Human Molecular Genetics. 4 (4): 751–754. doi:10.1093/hmg/4.4.751. ISSN 0964-6906. PMID 7633428. Cite has empty unknown parameters: |authorlinklink= and |authorlinklink3= (help)
  10. Vecchiet, L.; Montanari, G.; Pizzigallo, E.; Iezzi, S.; de Bigontina, P.; Dragani, L.; Vecchiet, J.; Giamberardino, M.A. (April 19, 1996). "Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome". Neuroscience Letters. 208 (2): 117–120. doi:10.1016/0304-3940(96)12559-3. ISSN 0304-3940. PMID 8859904.
  11. Fulle, S.; Mecocci, P.; Fanó, G.; Vecchiet, I.; Vecchini, A.; Racciotti, D.; Cherubini, A.; Pizzigallo, E.; Vecchiet, L. (December 15, 2000). "Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome". Free Radical Biology & Medicine. 29 (12): 1252–1259. doi:10.1016/s0891-5849(00)00419-6. ISSN 0891-5849. PMID 11118815.
  12. Kuratsune, H.; Yamaguti, K.; Takahashi, M.; Misaki, H.; Tagawa, S.; Kitani, T. (January 1994). "Acylcarnitine deficiency in chronic fatigue syndrome". Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. 18 (Suppl 1): S62–67. doi:10.1093/clinids/18.supplement_1.s62. ISSN 1058-4838. PMID 8148455. Cite has empty unknown parameters: |authorlinklink= and |authorlinklink3= (help)
  13. Plioplys, A.V.; Plioplys, S. (1995). "Serum levels of carnitine in chronic fatigue syndrome: clinical correlates". Neuropsychobiology. 32 (3): 132–138. doi:10.1159/000119226. ISSN 0302-282X. PMID 8544970.
  14. McCully, K. K.; Natelson, B. H.; Iotti, S.; Sisto, S.; Leigh, J. S. (May 1996). "Reduced oxidative muscle metabolism in chronic fatigue syndrome". Muscle & Nerve. 19 (5): 621–625. doi:10.1002/(SICI)1097-4598(199605)19:53.0.CO;2-Q. ISSN 0148-639X. PMID 8618560. Cite has empty unknown parameters: |authorlinklink= and |authorlinklink3= (help)
  15. R.H. Edwards, H. Gibson, J.E. Clague, T. Helliwell Muscle histopathology and physiology in chronic fatigue syndrome. CIBA Found. Symp., 173 (1993), pp. 102-117 (discussion 117–131)
  16. Edwards, R. H. T.; Gibson, H.; Clague, J. E.; Helliwell, T. (September 28, 2007), "Muscle Histopathology and Physiology in Chronic Fatigue Syndrome", Ciba Foundation Symposium 173‐Chronic Fatigue Syndrome, Chichester, UK: John Wiley & Sons, Ltd., pp. 102–131, ISBN 978-0-470-51438-2 Cite has empty unknown parameters: |authorlinklink3= and |authorlinklink= (help)