Mitochondrial antiviral signaling protein: Difference between revisions
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Mitochondrial antiviral-signaling protein (MAVS) is a protein encoded by the MAVS gene. It mediates the activation of [[NFκB]] and [[IRF]]s and the induction of [[interferon]]s in response to viral infection. | Mitochondrial antiviral-signaling protein (MAVS) is a protein encoded by the MAVS gene. It mediates the activation of [[NFκB]] and [[IRF]]s and the induction of [[interferon]]s in response to viral infection. | ||
MAVS is also a pro- | MAVS is also a pro-apoptosis molecule that triggers disruption of the mitochondrial membrane potential and activation of [[caspase]]s.<ref>{{Cite journal|last=Yu|first=Chia-Yi|date=December 2009|title=The Interferon Stimulator Mitochondrial Antiviral Signaling Protein Facilitates Cell Death by Disrupting the Mitochondrial Membrane Potential and by Activating Caspases|url=http://jvi.asm.org/content/84/5/2421.short|journal=Journal of Virology|volume=|pages=|via=}}</ref> | ||
Many viruses evade the host innate immune response by cleaving MAVS from mitochondria. [[Coxsackievirus B3]] cleaves MAVS protein to inhibit type I [[interferon]] induction.<ref>{{Cite journal|last=Mukherjee|first=A|date=March 2011|title=The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling|url=https://www.ncbi.nlm.nih.gov/pubmed/21436888?dopt=Abstract|journal=PLoS Pathology|volume=7|pages=|via=}}</ref> | Many viruses evade the host innate immune response by cleaving MAVS from mitochondria. [[Coxsackievirus B3]] cleaves MAVS protein to inhibit type I [[interferon]] induction.<ref>{{Cite journal|last=Mukherjee|first=A|date=March 2011|title=The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling|url=https://www.ncbi.nlm.nih.gov/pubmed/21436888?dopt=Abstract|journal=PLoS Pathology|volume=7|pages=|via=}}</ref> |
Revision as of 22:45, January 14, 2020
Mitochondrial antiviral-signaling protein (MAVS) is a protein encoded by the MAVS gene. It mediates the activation of NFκB and IRFs and the induction of interferons in response to viral infection.
MAVS is also a pro-apoptosis molecule that triggers disruption of the mitochondrial membrane potential and activation of caspases.[1]
Many viruses evade the host innate immune response by cleaving MAVS from mitochondria. Coxsackievirus B3 cleaves MAVS protein to inhibit type I interferon induction.[2]
MAVS plays a role in maintaining intestinal homeostasis. MAVS knockout mice developed more severe mortality and morbidity than wild type mice in an experimental model of colitis.[3]
References[edit | edit source]
- ↑ Yu, Chia-Yi (December 2009). "The Interferon Stimulator Mitochondrial Antiviral Signaling Protein Facilitates Cell Death by Disrupting the Mitochondrial Membrane Potential and by Activating Caspases". Journal of Virology.
- ↑ Mukherjee, A (March 2011). "The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling". PLoS Pathology. 7.
- ↑ Li, Xiao-Dong (October 8, 2011). "Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis". Proceedings of the National Academy of Sciences. 108: 17390–17395.