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Mitochondrial antiviral signaling protein
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Mitochondrial antiviral-signaling protein (MAVS) is a protein encoded by the MAVS gene. It mediates the activation of [[NFฮบB]] and [[IRF]]s and the induction of [[interferon]]s in response to viral infection. MAVS is also a pro-apoptosis molecule that triggers disruption of the mitochondrial membrane potential and activation of [[caspase]]s.<ref>{{Cite journal | last = Yu | first = Chia-Yi | date = December 2009 | title = The Interferon Stimulator Mitochondrial Antiviral Signaling Protein Facilitates Cell Death by Disrupting the Mitochondrial Membrane Potential and by Activating Caspases|url=http://jvi.asm.org/content/84/5/2421.short|journal=Journal of Virology|volume=|pages=|via=}}</ref> Many viruses evade the host innate immune response by cleaving MAVS from mitochondria. [[Coxsackievirus B3]] cleaves MAVS protein to inhibit type I [[interferon]] induction.<ref>{{Cite journal | last = Mukherjee | first = A | date = March 2011 | title = The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling | url =https://www.ncbi.nlm.nih.gov/pubmed/21436888?dopt=Abstract|journal=PLoS Pathology|volume=7|pages=|via=}}</ref> MAVS plays a role in maintaining [[intestinal]] homeostasis. MAVS knockout mice developed more severe mortality and morbidity than [[wild type]] mice in an experimental model of [[colitis]].<ref>{{Cite journal | last = Li | first = Xiao-Dong | date = October 8, 2011 | title = Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis|url=http://www.pnas.org/content/108/42/17390|journal=Proceedings of the National Academy of Sciences|volume=108|pages=17390-17395|via=}}</ref> ==References== {{Reflist}} [[Category:Genes]] [[Category:Proteins]] {{Reflist}} [[Category:Mitochondria]]
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