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Michael Maes
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==Neuro-Inflammatory and Oxidative Fatigue (NIOF) Theory== In 2015, Maes developed a new case definition of [[myalgic encephalomyelitis]]/[[chronic fatigue syndrome]] (ME/CFS) called [[Neuro-Inflammatory and Oxidative Fatigue]] (NIOF) "based on pattern recognition methods and using neuro-immune, inflammatory, oxidative and nitrosative stress (neuro-IO&NS) biomarkers as external validating criteria." These biomarkers include "[[Immuglobulin M|IgM]] / [[Immuglobulin A|IgA]] responses against LPS ([[lipopolysaccharide]]s) of gut commensal bacteria ([[leaky gut]]), IgM responses to O&NS modified neoepitopes, autoimmunity to serotonin, plasma interleukin-1 ([[interleukin 1|IL-1]]) and serum neopterin." Maes sees a "significant overlap between NIOF and chronic fatigue syndrome although NIOF criteria were much more restrictive."<ref name="Maes, 2015" /> Professor Maes proposes the ME/CFS, as well as other chronic diseases, can be treated by lessening the [[Neuro-Inflammatory and Oxidative Fatigue]] with foods and supplements that decrease inflammation and repair [[leaky gut]] such as [[curcumin]], [[N-acetyl-cysteine]] ββ(NAC), [[glutamine]], [[zinc]], and [[omega 3 fatty acid hypothesis|omega-3 fats]].<ref name="revitalis" />
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