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Mast cell activation syndrome
(section)
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==Diagnosis== MCAS can be difficult to diagnose as the cause of the syndrome is still considered to be unknown. In 2010, a criteria for diagnosing MCAS was proposed by Dr. Cem Akin and colleagues. These criteria suggest that two or more organ systems must be affected; this can include gastrointestinal, [[Cardiovascular system|cardiovascular]], skin, or respiratory. If given anti-histamine or mast cell therapy, the patient's symptoms must improve. Thirdly, the patient should be tested for serum [[tryptase]], an enzyme secreted by mast cells during the peak of a symptomatic episode. If tryptase is >15ng/mL, the patient may have MCAS. Urine and blood tests should be collected more than once to confirm a positive diagnosis. Prostaglandin and histamine levels can be also be tested.<ref name="Akin2010">{{Cite journal | last = Akin | first = Cem | date = 2010 | title=Mast Cell Activation Syndrome: Proposed Diagnostic Criteria|url=https://pubmed.ncbi.nlm.nih.gov/21035176/|journal=J Allergy and Clinical Immuno|volume=126|issue=6|pages=1099-104.e4| doi=10.1016/j.jaci.2010.08.035|via=}}</ref>
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