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{{NeedsImage}} '''Mark A. Vink''', MD, is a General Practitioner and insurance doctor in [[Netherlands|The Netherlands]]. He lives with [[Severe and very severe ME|severe ME/CFS]] triggered by pneumonia and prolonged by [[graded exercise therapy]] (GET). As a result of his adverse experience with GET, he has been a vocal critic of the [[PACE trial]].<ref name="Vink2015" /> One piece written about the [[PACE trial]] garnished him a nomination for the 2016 [[John Maddox Prize]], an international award for an individual who promotes sound science despite difficulty or hostility in doing so.<ref>{{Cite web|url=http://senseaboutscience.org/activities/the-john-maddox-prize/ | title = The John Maddox Prize – Sense about Science|website=senseaboutscience.org|language=en-US|access-date=2018-11-12}}</ref> Before becoming ill with [[myalgic encephalomyelitis]], Mark Vink ran marathons, competed in triathlons, was a Dutch national hockey captain, and a brown belt in judo.<ref name="marathon">{{Cite web|url=http://anilvanderzee.com/for-patients-with-cfs-going-to-the-bathroom-is-similar-to-running-a-marathon/ | title = For patients with CFS, going to the bathroom is similar to running a marathon. | last=de Visser | first = Ellen | authorlink=Ellen de Visser | date = 2017-10-03 | website = [[Anil van der Zee]]|language=en-GB|archive-url=|archive-date=|url-status=|access-date=2018-12-29}}</ref> == Aerobic Threshold / Lactic Acid Study == While bedridden with [[Severe and very severe ME|severe M.E.]], Dr Vink carried out a biomedical study on himself, collecting blood with finger prick lancets and pediatric sized tubes. By measuring [[creatine kinase]], inorganic [[phosphate]] and [[Lactic acidosis|lactic acid]] before and after trivial [[exercise]] (i.e., walking the 5 to 6 yards from his bed to the toilet and back), he showed that his aerobic energy production and [[lactic acid]] excretion were both impeded.<ref name="Vink2015" /> The results of Vink's 2015 study were reported in a Dutch national newspaper as finding that the physical impact of going to the bathroom was similar to that of running a marathon for people with [[chronic fatigue syndrome]],<ref name="volkskrant">{{Cite web|url=https://www.volkskrant.nl/wetenschap/als-je-cvs-hebt-is-naar-de-wc-gaan-al-een-marathon~b4b45b16/ | title = Als je CVS hebt is naar de wc gaan al een marathon | last = de Visser | first = Ellen | authorlink=Ellen de Visser | date = Oct 3, 2017 | website = volkskrant.nl|archive-url=|archive-date=|url-status=|access-date=2018-12-29}}</ref><ref name="marathon" /> although what Vink found was that his own lactic acid levels were ''higher'' than those at which most professional atheletes would have quit.<ref name="Vink2015" /> ==An open letter to Psychological Medicine about "recovery" and the PACE trial== Dr. Vink was one of the signatories of [[an open letter to Psychological Medicine about “recovery” and the PACE trial]] dated March 13, 2017 urging ''Psychological Medicine'' to retract a paper claiming recovery for ME/CFS patients by using [[graded exercise therapy]] and [[cognitive behavioral therapy]]. ==Notable studies== *2022, Is It Useful to Question the Recovery Behaviour of Patients with ME/CFS or Long COVID?<ref name="Vink2022review">{{Cite journal | title = Is It Useful to Question the Recovery Behaviour of Patients with ME/CFS or Long COVID? | date = Feb 2022|url=https://www.mdpi.com/2227-9032/10/2/392|journal=Healthcare|volume=10|issue=2 | pages = 392 | last = Vink|first = Mark | authorlink = Mark Vink | last2 = Vink-Niese | first2 = Friso | authorlink2 = |language=en|doi=10.3390/healthcare10020392|pmc=|pmid=|access-date=|issn=2227-9032|quote=|via=}}</ref> - [https://www.mdpi.com/2227-9032/10/2/392/htm (Full text)] *2021, CFS patients remain severely disabled after specialist treatment with CBT in the UK<ref name="Vink2021-CBT">{{Cite journal | title = CFS patients remain severely disabled after specialist treatment with CBT in the UK | date = 2021-05-27|url=https://dx.doi.org/10.1177/01410768211013447|journal=Journal of the Royal Society of Medicine|volume=114|issue=6|pages=284–284 | last = Vink|first = Mark | authorlink = Mark Vink | last2 = Vink-Niese | first2 = Alexandra | authorlink2 = |doi=10.1177/01410768211013447|pmc=PMC8212546|pmid=34042529|access-date=|issn=0141-0768|quote=|via=}}</ref> - [https://www.researchgate.net/profile/Mark-Vink-2/publication/351914009_CFS_patients_remain_severely_disabled_after_specialist_treatment_with_CBT_in_the_UK/links/60afa16c458515bfb0aaebdf/CFS-patients-remain-severely-disabled-after-specialist-treatment-with-CBT-in-the-UK.pdf (Full text)] *2021, The draft updated NICE guidance for ME/CFS highlights the unreliability of subjective outcome measures in non-blinded trials<ref name="Vink2021a">{{Cite journal | title = The draft updated NICE guidance for ME/CFS highlights the unreliability of subjective outcome measures in non-blinded trials | date = 2021-01-28|url=https://journals.sagepub.com/doi/abs/10.1177/1359105321990810|journal=Journal of Health Psychology|volume=27|issue=1 | pages = 9–12 | last = Vink|first = Mark | authorlink = Mark Vink | last2 = Vink-Niese | first2 = Alexandra | authorlink2 = |doi=10.1177/1359105321990810|pmc=|pmid=|access-date=|issn=1359-1053|quote=|via=}}</ref> - [https://www.researchgate.net/profile/Mark-Vink-2/publication/348858442_The_draft_updated_NICE_guidance_for_MECFS_highlights_the_unreliability_of_subjective_outcome_measures_in_non-blinded_trials/links/60271f5a45851589399ee2e3/The-draft-updated-NICE-guidance-for-ME-CFS-highlights-the-unreliability-of-subjective-outcome-measures-in-non-blinded-trials.pdf (Full text)] *2021, Is ME/CVS-patiënten op hun herstelgedrag aanspreken zinvol? Een review van de literatuur<ref name="Vink2021-lit">{{Cite journal | title = Is ME/CVS-patiënten op hun herstelgedrag aanspreken zinvol? | date = 2021-04-01|url=https://www.researchgate.net/publication/350718562_Is_MECVS-patienten_op_hun_herstelgedrag_aanspreken_zinvol_Een_review_van_de_literatuur|journal=TBV – Tijdschrift voor Bedrijfs- en Verzekeringsgeneeskunde|volume=29|issue=4 | pages = 44–49 | last = Vink|first = Mark | authorlink = Mark Vink | last2 = Vink-Niese | first2 = Friso | authorlink2 = |language=nl|doi=10.1007/s12498-021-1362-x|pmc=|pmid=|access-date=|issn=1876-5858|quote=|via=}}</ref> - [https://www.researchgate.net/publication/350718562_Is_MECVS-patienten_op_hun_herstelgedrag_aanspreken_zinvol_Een_review_van_de_literatuur (Full text)] - In Dutch *2020, Could Cognitive Behavioural Therapy Be an Effective Treatment for Long COVID and Post COVID-19 Fatigue Syndrome? Lessons from the Qure Study for Q-Fever Fatigue Syndrome<ref name="Vink2020LC">{{Cite journal | title = Could Cognitive Behavioural Therapy Be an Effective Treatment for Long COVID and Post COVID-19 Fatigue Syndrome? Lessons from the Qure Study for Q-Fever Fatigue Syndrome | date = 2020-12-11|url=https://www.mdpi.com/2227-9032/8/4/552|journal=Healthcare|volume=8|issue=4 | pages = 552 | last = Vink|first = Mark | authorlink = Mark Vink | last2 = Vink-Niese | first2 = Alexandra | authorlink2 = |language=en|doi=10.3390/healthcare8040552|pmc=PMC7764131|pmid=33322316|access-date=|issn=2227-9032|quote=|via=}}</ref> - [https://www.mdpi.com/2227-9032/8/4/552 (Full text)] *2020, Graded exercise therapy doesn't restore the ability to work in ME/CFS. Rethinking of a Cochrane review<ref name="Vink2020GET">{{Cite journal | title = Graded exercise therapy does not restore the ability to work in ME/CFS – Rethinking of a Cochrane review | date = 2020-01-01|url=https://www.researchgate.net/profile/Mark-Vink-2/publication/342323894_Graded_exercise_therapy_doesn't_restore_the_ability_to_work_in_MECFS_Rethinking_of_a_Cochrane_review/links/5f1add8745851515ef44e56d/Graded-exercise-therapy-doesnt-restore-the-ability-to-work-in-ME-CFS-Rethinking-of-a-Cochrane-review.pdf | journal=Work|volume=66|issue=2|pages=283–308 | last = Vink|first = Mark | authorlink = | last2 = Vink-Niese | first2 = Friso | authorlink2 = |language=en|doi=10.3233/WOR-203174|pmc=|pmid=|access-date=|issn=1051-9815|quote=|via=}}</ref> - [https://www.researchgate.net/profile/Mark-Vink-2/publication/342323894_Graded_exercise_therapy_doesn't_restore_the_ability_to_work_in_MECFS_Rethinking_of_a_Cochrane_review/links/5f1add8745851515ef44e56d/Graded-exercise-therapy-doesnt-restore-the-ability-to-work-in-ME-CFS-Rethinking-of-a-Cochrane-review.pdf (Full text)] *2019, Work Rehabilitation and Medical Retirement for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients. A Review and Appraisal of Diagnostic Strategies<ref name="Vink2019rehab">{{Cite journal | last = Vink | last2 = Vink-Niese | date = 2019-09-20 | title = Work Rehabilitation and Medical Retirement for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients. A Review and Appraisal of Diagnostic Strategies|url=https://www.mdpi.com/2075-4418/9/4/124|journal=Diagnostics|language=en|volume=9|issue=4|pages=124|doi=10.3390/diagnostics9040124|issn=2075-4418|first = Mark | first2 = Alexandra|pmc=|pmid=|quote= | author-link = Mark Vink | authorlink2 = Alexandra Vink-Niese|access-date=|via=}}</ref> - [https://www.mdpi.com/2075-4418/9/4/124/htm (Full text)] *2019, Cognitive behavioural therapy for myalgic encephalomyelitis/chronic fatigue syndrome is not effective. Re-analysis of a Cochrane review<ref name="Vink2019CBT">{{Cite journal | title = Cognitive behavioural therapy for myalgic encephalomyelitis/chronic fatigue syndrome is not effective. Re-analysis of a Cochrane review | date = Jan 2019|url=https://journals.sagepub.com/doi/full/10.1177/2055102919840614|journal=Health Psychology Open|volume=6|issue=1|pages=205510291984061 | last = Vink|first = Mark | authorlink = Mark Vink | last2 = Vink-Niese | first2 = Alexandra | authorlink2 = |doi=10.1177/2055102919840614|pmc=PMC6498783|pmid=31080632|access-date=|issn=2055-1029|quote=|via=}}</ref> - [https://journals.sagepub.com/doi/full/10.1177/2055102919840614 (Full text)] *2018, Multidisciplinary rehabilitation treatment is not effective for myalgic encephalomyelitis/chronic fatigue syndrome: A review of the FatiGo trial<ref name="Vink2018MRT">{{Cite journal | last = Vink|first = Mark | authorlink = Mark Vink | last2 = Vink-Niese | first2 = Alexandra | date = Jul 2018 | title = Multidisciplinary rehabilitation treatment is not effective for myalgic encephalomyelitis/chronic fatigue syndrome: A review of the FatiGo trial|url=http://journals.sagepub.com/doi/10.1177/2055102918792648|journal=Health Psychology Open|language=en|volume=5|issue=2|pages=205510291879264|doi=10.1177/2055102918792648|issn=2055-1029|pmc=|pmid=30094055|via=|quote= | authorlink2 = Alexandra Vink-Niese}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080079/ (Full text)] *2018, Graded exercise therapy for myalgic encephalomyelitis/chronic fatigue syndrome is not effective and unsafe. Re-analysis of a Cochrane review<ref name="Vink2018GET">{{Cite journal | last = Vink|first = Mark | authorlink = Mark Vink | last2 = Vink-Niese | first2 = Alexandra | date = Jul 2018 | title = Graded exercise therapy for myalgic encephalomyelitis/chronic fatigue syndrome is not effective and unsafe. Re-analysis of a Cochrane review | url =https://www.ncbi.nlm.nih.gov/pubmed/30305916|journal=Health Psychology Open|volume=5|issue=2|pages=2055102918805187|doi=10.1177/2055102918805187|issn=2055-1029|pmc=|pmid=30305916|via=|quote= | authorlink2 = Alexandra Vink-Niese}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176540/ (Full Text)] * 2017, FITNET's Internet-Based Cognitive Behavioural Therapy Is Ineffective and May Impede Natural Recovery in Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. A Review<ref name="Ghatineh2017">{{Cite journal | last = Ghatineh|first = Simin | authorlink = Simin Ghatineh | last2 = Vink | first2 = Mark | authorlink2 = Mark Vink | authorlink5 = | date = 2017-08-11 | title = FITNET’s Internet-Based Cognitive Behavioural Therapy Is Ineffective and May Impede Natural Recovery in Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. A Review | url =https://www.mdpi.com/2076-328X/7/3/52|journal=Behavioral Sciences|language=en|volume=7|issue=3 | pages = 52|doi=10.3390/bs7030052|pmc=5618060|pmid=28800089|quote=|via=}}</ref> - [http://www.mdpi.com/2076-328X/7/3/52/htm (Full text)] *2017, PACE trial authors continue to ignore their own null effect<ref name="Vink2017null">{{Cite journal | last = Vink|first = Mark | date = 2017-04-27 | title = PACE trial authors continue to ignore their own null effect|url=http://journals.sagepub.com/doi/10.1177/1359105317703785|journal=Journal of Health Psychology|language=en|volume=22|issue=9|pages=1134–1140|doi=10.1177/1359105317703785|issn=1359-1053}}</ref> - [http://journals.sagepub.com/doi/10.1177/1359105317703785 (Full text)] *2017, Assessment of Individual PACE Trial Data: in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Cognitive Behavioral and Graded Exercise Therapy are Ineffective, Do Not Lead to Actual Recovery and Negative Outcomes may be Higher than Reported<ref name="Vinl2017data">{{Cite journal | last = Vink|first = Mark | date = 2017 | title=Assessment of Individual PACE Trial Data in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Cognitive Behavioual Therapy and Graded Exercise Therapy are Ineffective, Do Not Lead to Actual Recovery and Negative Outcomes may be Higher than Reported | url =https://www.researchgate.net/publication/312328779_Assessment_of_Individual_PACE_Trial_Data_in_Myalgic_EncephalomyelitisChronic_Fatigue_Syndrome_Cognitive_Behavioral_and_Graded_Exercise_Therapy_are_Ineffective_Do_Not_Lead_to_Actual_Recovery_and_Negati|journal=J Neuro Neurobiol|volume=3|issue=1|pages=|doi=10.16966/2379-7150.136|quote=|via=}}</ref> - [https://www.researchgate.net/publication/312328779_Assessment_of_Individual_PACE_Trial_Data_in_Myalgic_EncephalomyelitisChronic_Fatigue_Syndrome_Cognitive_Behavioral_and_Graded_Exercise_Therapy_are_Ineffective_Do_Not_Lead_to_Actual_Recovery_and_Negati (Full text)] *2016, The PACE Trial Invalidates the Use of Cognitive Behavioral and Graded Exercise Therapy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review<ref name="Vink2016PACE">{{Cite journal | last = Vink|first = Mark | date = 2016 | title=The PACE Trial Invalidates the Use of Cognitive Behavioral and Graded Exercise Therapy in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome: A Review | url =http://dx.doi.org/10.16966/2379-7150.124|journal=Journal of Neurology and Neurobiology|volume=2|issue=3|doi=10.16966/2379-7150.124|issn=2379-7150}}</ref> - [https://www.researchgate.net/publication/301202396_The_PACE_Trial_Invalidates_the_Use_of_Cognitive_Behavioral_and_Graded_Exercise_Therapy_in_Myalgic_Encephalomyelitis_Chronic_Fatigue_Syndrome_A_Review?ev=prf_high (Full text)] *2015, The Aerobic Energy Production and the Lactic Acid Excretion are both Impeded in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome<ref name="Vink2015">{{Cite journal | last = Vink|first = Mark | date = 2015-09-10 | title = The Aerobic Energy Production and the Lactic Acid Excretion are both Impeded in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|url=https://www.researchgate.net/publication/282133390_The_Aerobic_Energy_Production_and_the_Lactic_Acid_Excretion_are_both_Impeded_in_Myalgic_EncephalomyelitisChronic_Fatigue_Syndrome|journal=Journal of Neurology and Neurobiology (ISSN 2379-7150)|volume=1|doi=10.16966/2379-7150.112}}</ref> - [https://www.researchgate.net/publication/282133390_The_Aerobic_Energy_Production_and_the_Lactic_Acid_Excretion_are_both_Impeded_in_Myalgic_EncephalomyelitisChronic_Fatigue_Syndrome (Full text)] ==Talks and interviews== * 3 Oct 2017 - Interview of Dr Mark Vink in Volkskrant [https://www.volkskrant.nl/wetenschap/als-je-cvs-hebt-is-naar-de-wc-gaan-al-eenmarathon~a4519279/?hash=028240debc501ca3d04f32b616572aace48beca9 'Als je CVS hebt is naar de wc gaan al een marathon']<ref name="volkskrant" />/ [http://anilvanderzee.com/for-patients-with-cfs-going-to-the-bathroom-is-similar-to-running-a-marathon/ 'For patients with CFS, going to the bathroom is similar to running a marathon.']<ref name="marathon" /> ==Online presence== *[https://www.researchgate.net/profile/Mark_Vink ResearchGate] *[https://twitter.com/Huisarts_Vink?lang=en Twitter] *[https://scholar.google.com/citations?user=1ChM2bUAAAAJ&hl=en Google Scholar] *[https://www.linkedin.com/in/mark-a-vink-1678b418/ LinkedIn] ==Learn more== *Sep 25, 2015 - [https://www.healthrising.org/blog/2015/09/25/walking-marathon-me-cfs-case-study/ "How Walking to Bathroom Can Be Harder Than Running a Marathon: A Doctor’s ME/CFS Case Study"]<ref>{{Cite web|url=https://www.healthrising.org/blog/2015/09/25/walking-marathon-me-cfs-case-study/ | title = How Walking to Bathroom Can Be Harder Than Running a Marathon: A Doctor's ME/CFS Case Study | last = Johnson | first =Cort | authorlink=Cort Johnson | date = 2015-09-25 | website = [[Health Rising]]|language=en-GB|archive-url=|archive-date=|url-status=|access-date=2018-12-29}}</ref> by [[Cort Johnson]] in [[Health Rising]] ==See also== *[[PACE trial]] *[[FatiGo trial]] *[[FITNET trial]] *[[An open letter to Psychological Medicine about “recovery” and the PACE trial]] ==References== {{Reflist}} [[Category:Researchers]] [[Category:Netherlands researchers]] [[Category:Clinicians]] [[Category:Dutch clinicians]] [[Category:People with ME, CFS, and/or FMS]] [[Category:PACE trial critics]] [[Category:Advocates or allies]] [[Category:Dutch advocates or allies]] [[Category:Citizen scientists]] [[Category:Psychological paradigm critics]] [[Category:Dutch famous people with ME, CFS, and/or FMS]]
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