Long COVID pathophysiology: Difference between revisions
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'''[[Long COVID]]''', '''long tail covid''', '''Post-Acute Sequelae of COVID-19''' '''(PASC)''', '''post-acute COVID-19''' and '''ongoing COVID''' are terms used to describe a group of long term health problems that are found in a significant minority of people who developed [[COVID-19]] and remain ill a number of weeks or months later. | '''[[Long COVID]]''', '''long tail covid''', '''Post-Acute Sequelae of COVID-19''' '''(PASC)''', '''post-acute COVID-19''' and '''ongoing COVID''' are terms used to describe a group of long term health problems that are found in a significant minority of people who developed [[COVID-19]] and remain ill a number of weeks or months later. | ||
== Overview == | |||
{{Main article|page_name=Long COVID}} | |||
== Pathophysiology == | == Pathophysiology == | ||
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== References == | == References == | ||
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Revision as of 14:41, August 11, 2021
Long COVID, long tail covid, Post-Acute Sequelae of COVID-19 (PASC), post-acute COVID-19 and ongoing COVID are terms used to describe a group of long term health problems that are found in a significant minority of people who developed COVID-19 and remain ill a number of weeks or months later.
Overview[edit | edit source]
Pathophysiology[edit | edit source]
Infection and immunity[edit | edit source]
A range of antibodies have been found in patients with persistent post-acute COVID symptoms. Elevated G-protein coupled receptor autoantibodies have been found.[1] One study founded elevated antinuclear antibody (ANA) titles in 43.6% of long COVID patients twelve months after symptom onset.[2]
Neurological and neuropsychiatric[edit | edit source]
Cardiovascular[edit | edit source]
Pulmonary[edit | edit source]
Comparison to other conditions[edit | edit source]
Post-acute SARS[edit | edit source]
ME/CFS[edit | edit source]
POTS[edit | edit source]
MCAS[edit | edit source]
Alzheimer’s[edit | edit source]
Traumatic Brain Injury[edit | edit source]
Findings | Long COVID | Post-acute SARS | ME/CFS | POTS | MCAS |
---|---|---|---|---|---|
G-protein coupled receptor autoantibodies | β2- and α1-adrenoceptors, angiotensin II AT1-, muscarinic M2-, MAS-, nociceptin- and ETA-receptors | M3 and M4 muscarinic acetylcholine receptors, as well as ß2 adrenergic receptors | α1, β1 and β2 adrenergic receptor autoantibodies | ||
See also[edit | edit source]
Learn more[edit | edit source]
- Long COVID Resource Hub (database of Long COVID research)
References[edit | edit source]
- ↑ "Functional autoantibodies against G-protein coupled receptors in patients with persistent Long-COVID-19 symptoms". Journal of Translational Autoimmunity. 4: 100100. January 1, 2021. doi:10.1016/j.jtauto.2021.100100. ISSN 2589-9090.
- ↑ Seeßle, Jessica; Waterboer, Tim; Hippchen, Theresa; Simon, Julia; Kirchner, Marietta; Lim, Adeline; Müller, Barbara; Merle, Uta (July 5, 2021). "Persistent symptoms in adult patients one year after COVID-19: a prospective cohort study". Clinical Infectious Diseases (ciab611). doi:10.1093/cid/ciab611. ISSN 1058-4838.