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London criteria
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== Criticism == The citation for the original London criteria typically given is:<br> EG Dowsett, E Goudsmit, A Macintyre, C Shepherd, et al., London criteria for M.E., Report from The National Task Force on Chronic Fatigue Syndrome (CFS), Post Viral Fatigue Syndrome (PVFS), Myalgic Encephalomyelitis (ME). Westcare, 1994, pp. 96-98. However, [[Malcolm Hooper]] and [[Margaret Williams]] both point out that this report does not include any author names.<ref name="Williams">{{Cite web|url=https://www.margaretwilliams.me/2005/cs-discrepancy-re-lc-on-co-cure.pdf | first = Margaret|last = Williams | authorlink = Margaret Williams | date = May 18, 2005 | title = Correct Citation for the "London" criteria?}}</ref> === Use in the PACE-trial === The London criteria came back into the center of attention when [[Peter White|White]] et al. announced they were going to use the London criteria to diagnose ME patients in the [[PACE trial]].<ref>{{Cite journal|last = White | first = Peter D | last2 = Sharpe | first2 = Michael C | last3 = Chalder | first3 = Trudie | last4 = DeCesare | first4 = Julia C | last5 = Walwyn | first5 = Rebecca | date = 2007-03-08 | title = Protocol for the PACE trial: A randomised controlled trial of adaptive pacing, cognitive behaviour therapy, and graded exercise as supplements to standardised specialist medical care versus standardised specialist medical care alone for patients with the chronic fatigue syndrome/myalgic encephalomyelitis or encephalopathy|url=http://dx.doi.org/10.1186/1471-2377-7-6|journal=BMC Neurology|volume=7|issue=1|doi=10.1186/1471-2377-7-6|issn=1471-2377}}</ref> The actual version used in the [[PACE trial]] was however a modified version of the London criteria, not approved by any of the authors. [[Ellen Goudsmit]] for example wrote: “The version used in the PACE trial was not written by any of those who were involved with the London criteria. I’ve seen the manual and don’t recognize it.”<ref name="Londoncriteria" /> The [[PACE trial|PACE]] authors referred to the report from the National Task Force on ME, yet not all details of the London Criteria were published in that report.The directive to exclude psychological disorders for example was not mentioned. In the 1993 version, made available online by [[Charles Shepherd]] and the ME Association, the following passage was included:<blockquote> “Of particular importance is to eliminate chronic fatigue primarily associated with psychological factors. If there are signs of persistent anhedonia, apathy, low self-esteem, feelings of worthlessness and guilt, the possibility: of primary depressive illness should be actively considered and, if there is any doubt whatsoever, the subject eliminated from the research study.”<ref name="Londoncriteria" /></blockquote>The published data of the [[PACE trial]] do not make clear if psychological disorders had been excluded, as the original London criteria required.<ref>{{Cite journal|last = Goudsmit | first = Ellen | last2 = Howes | first2 = Sandra | date = 2017-05-29 | title = Bias, misleading information and lack of respect for alternative views have distorted perceptions of myalgic encephalomyelitis/chronic fatigue syndrome and its treatment|url=http://journals.sagepub.com/doi/pdf/10.1177/1359105317707216|journal=Journal of Health Psychology|language=en|volume=22|issue=9|pages=1159–1167|doi=10.1177/1359105317707216|issn=1359-1053}}</ref> According to [[Ellen Goudsmit|Goudsmit]], the fact that the London criteria (LC) were used in the [[PACE trial]], instigated a backlash against the criteria among ME advocates: <blockquote>"The LC were generally considered a good thing when the study was published in 1995. It became an issue only when the LC were included in the protocol for the PACE Trial. This introduced a political element, i.e. some argued that if one could show that the LC were no good, what was it doing in an expensive, government funded trial and the only proper action was to stop that trial. We all got that. Activists therefore began questioning everything they could about the LC."<ref name="Londoncriteria" /></blockquote>[[Malcolm Hooper]] had for example written: <blockquote>The 'London Criteria' have no known authors; they have never been published; there is no methods paper which specifically describes them as a "case definition"; they have never been approved nor have they even been finally defined (there are various versions); they have never been validated and they are not on PubMed thus are not available for scrutiny so they cannot be accessed for comparison. This means that [[Peter White|Professor White]] was essentially able to create his own version of the London Criteria.<ref>{{Cite news | url=https://forums.phoenixrising.me/index.php?threads/pace-study-and-oxford-criteria.8880/page-2 | title = PACE study and oxford criteria|work=Phoenix Rising ME / CFS Forums|access-date=2018-08-30|language=en-US|last = Hooper | first = Malcolm | authorlink = Malcolm Hooper | date = |archive-url=|archive-date=|url-status=}}</ref></blockquote>
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