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==Definition== All patients should fulfill the following five criteria: # A new onset of significantly abnormal levels of [[muscle fatigability]] and/or [[muscle weakness]], [[post-exertional malaise|precipitated by relatively minor levels of activity]]. Symptoms typically worsen during the next 24-48 hours. # The presence of symptoms indicating the involvement of the [[brain]] and [[central nervous system]] (e.g. [[memory problems|impaired short-term memory]] and [[attention deficit|concentration]], [[sleep dysfunction|disturbed sleep]] patterns, [[balance problems]]). # Periods of [[poor circulation|impaired circulation]] compatible with [[autonomic dysfunction]] (e.g. [[facial pallor]], disturbances in thermoregulation including [[excessive sweating|inappropriate sweating]] and [[temperature sensitivity|sensitivity to both heat and cold]]; [[postural hypotension]] and/or [[orthostatic intolerance]]). # [[Fluctuating illness|Fluctuation of symptoms, from hour to hour and day to day]]. # These symptoms must have been present during the past three months (to exclude patients with the debility which often follows illnesses such as influenza).
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