List of herpesvirus infection studies

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Revision as of 21:38, August 19, 2020 by Hip (talk | contribs) (Added refs)

Herpesvirus family viruses including Epstein-Barr virus, human herpesvirus 6 (HHV-6) and cytomegalovirus are associated with myalgic encephalomyelitis. This article lists herpesvirus studies examining the role and prevalence of herpesviruses in ME/CFS patients. Positive studies (finding herpesvirus more prevalent in ME/CFS patients than healthy controls) are indicated by a + symbol, whereas negative studies (finding no significant difference in prevalence between patients and healthy) are indicated by the − symbol.

Epstein-Barr virus studies[edit | edit source]

Epstein-Barr virus (EBV) is found in 95% of the adult population (usually in a latent state),[1] and is the most common cause of mononucleosis.

Study Title Date Details
+ Chronic fatigue syndrome after infectious mononucleosis in adolescents

Ben Z Katz, Yukiko Shiraishi, Cynthia J Mears, Helen J Binns, Renee Taylor [2]

2009 This study of 301 adolescents with infectious mononucleosis found that at 6, 12, and 24 months after mononucleosis, 13%, 7%, and 4% of these adolescents respectively met the criteria for ME/CFS.
+ Antibody to Epstein-Barr virus deoxyuridine triphosphate nucleotidohydrolase and deoxyribonucleotide polymerase in a chronic fatigue syndrome subset

A Martin Lerner, Maria E Ariza, Marshall Williams, Leonard Jason, Safedin Beqaj, James T Fitzgerald, Stanley Lemeshow, Ronald Glaser [3]

2012 This study of 20 ME/CFS patients and 20 healthy controls found 94% of patients were positive for EBV early antigen diffuse, versus 32% of the healthy controls; 44% of patients were positive for EBV dUTPase, versus 0% of the controls; 79% of patients were positive for EBV DNA polymerase, versus 0% of the controls.
+ XXXX

XXXX

XXXX XXXX.

HHV-6 studies[edit | edit source]

HHV-6 is found in nearly 100% of adults (usually in a latent state).[4]

Study Title Date Details
+ Prevalence of human herpesvirus 6 variants A and B in patients with chronic fatigue syndrome

S Yalcin, H Kuratsune, K Yamaguchi, T Kitani, K Yamanishi [5]

2000 This study examined 13 cases of ME/CFS and 13 healthy controls. In the peripheral blood mononuclear cells, HHV-6 DNA was detected in 53% of the patients, but no HHV-6 DNA was detected in the controls. Higher antibody levels to the HHV-6 late antigen were found in patients, and antibodies to HHV-6 early antigen were more prevalent in patients.
+ XXXX

XXXX

XXXX XXXX.

Cytomegalovirus studies[edit | edit source]

Cytomegalovirus is found in 58% of adults (usually in a latent state).[6] Cytomegalovirus is a rarer cause of mononucleosis.

Study Title Date Details
+ XXXX

XXXX

XXXX XXXX.

Varicella zoster virus studies[edit | edit source]

Varicella zoster virus (VZV) is found in 88% of the adult population (usually in a latent state).[7] It causes chickenpox and shingles.

Study Title Date Details
+ XXXX

XXXX

XXXX XXXX.

Herpes simplex virus studies[edit | edit source]

Herpes simplex virus I is found in 54% of adults, and herpes simplex virus II in 16% of adults (usually in a latent state).[8] HSV causes oral mouth sores.

Study Title Date Details
+ XXXX

XXXX

XXXX XXXX.

HHV-7 studies[edit | edit source]

HHV-7 is found in more than 95% of the adult population (usually in a latent state).[9]

Study Title Date Details
+ XXXX

XXXX

XXXX XXXX.

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ "Epstein-barr | Mononucleosis | About Virus | Mono | CDC". www.cdc.gov. January 28, 2019. Retrieved August 19, 2020.
  2. ↑ Katz, Ben Z.; Shiraishi, Yukiko; Mears, Cynthia J.; Binns, Helen J.; Taylor, Renee (2009-07). "Chronic fatigue syndrome after infectious mononucleosis in adolescents". Pediatrics. 124 (1): 189–193. doi:10.1542/peds.2008-1879. ISSN 1098-4275. PMC 2756827. PMID 19564299. Check date values in: |date= (help)
  3. ↑ Lerner, A. Martin; Ariza, Maria E.; Williams, Marshall; Jason, Leonard; Beqaj, Safedin; Fitzgerald, James T.; Lemeshow, Stanley; Glaser, Ronald (2012). "Antibody to Epstein-Barr virus deoxyuridine triphosphate nucleotidohydrolase and deoxyribonucleotide polymerase in a chronic fatigue syndrome subset". PloS One. 7 (11): e47891. doi:10.1371/journal.pone.0047891. ISSN 1932-6203. PMC 3498272. PMID 23155374.
  4. ↑ Ansari, Asad; Li, Shaobing; Abzug, Mark J.; Weinberg, Adriana (2004-8). "Human Herpesviruses 6 and 7 and Central Nervous System Infection in Children1". Emerging Infectious Diseases. 10 (8): 1450–1454. doi:10.3201/eid1008.030788. ISSN 1080-6040. PMC 3320425. PMID 15496247. Check date values in: |date= (help)
  5. ↑ Yalcin, S.; Kuratsune, H.; Yamaguchi, K.; Kitani, T.; Yamanishi, K. (1994). "Prevalence of human herpesvirus 6 variants A and B in patients with chronic fatigue syndrome". Microbiology and Immunology. 38 (7): 587–590. doi:10.1111/j.1348-0421.1994.tb01827.x. ISSN 0385-5600. PMID 7968694.
  6. ↑ Dollard, Sheila C.; Staras, Stephanie A. S.; Amin, Minal M.; Schmid, D. Scott; Cannon, Michael J. (2011-11). "National prevalence estimates for cytomegalovirus IgM and IgG avidity and association between high IgM antibody titer and low IgG avidity". Clinical and vaccine immunology: CVI. 18 (11): 1895–1899. doi:10.1128/CVI.05228-11. ISSN 1556-679X. PMC 3209034. PMID 21918114. Check date values in: |date= (help)
  7. ↑ Fatha, Noorul; Ang, Li Wei; Goh, Kee Tai (2014-05). "Changing seroprevalence of varicella zoster virus infection in a tropical city state, Singapore". International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases. 22: 73–77. doi:10.1016/j.ijid.2013.10.003. ISSN 1878-3511. PMID 24269652. Check date values in: |date= (help)
  8. ↑ Bradley, Heather; Markowitz, Lauri E.; Gibson, Theda; McQuillan, Geraldine M. (February 1, 2014). "Seroprevalence of herpes simplex virus types 1 and 2--United States, 1999-2010". The Journal of Infectious Diseases. 209 (3): 325–333. doi:10.1093/infdis/jit458. ISSN 1537-6613. PMID 24136792.
  9. ↑ Clark, D. A.; Freeland, M. L.; Mackie, L. K.; Jarrett, R. F.; Onions, D. E. (1993-07). "Prevalence of antibody to human herpesvirus 7 by age". The Journal of Infectious Diseases. 168 (1): 251–252. doi:10.1093/infdis/168.1.251. ISSN 0022-1899. PMID 8390545. Check date values in: |date= (help)

antibodies Antibody/immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.

antibodies Antibody/immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.

antibodies Antibody/immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.

antibodies Antibody/immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.

cytomegalovirus (CMV) - A common herpesvirus found in humans. Like other herpesviruses, it is a life-long infection that remains in a latent state inside the human body, until it is 'reactivated' by appropriate conditions. CMV infects between 60% to 70% of adults in industrialized countries and close to 100% in emerging countries. Much is unknown about this virus, although it has been found in salivary glands and myeloid blood cells such as monocytes. It has also been linked to the development of certain cancers. Congenital CMV is a leading infectious cause of deafness, learning disabilities, and intellectual disability. A common treatment for CMV is valganciclovir, commonly known as Valcyte.

Retrieved from "https://me-pedia.org/w/index.php?title=List_of_herpesvirus_infection_studies&oldid=83660"