Lactic acid: Difference between revisions
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'''Lactic acid''' is a biologically important acid and a by-product of anaerobic metabolism. The conjugate base of lactic acid is called '''lactate'''. Most of the time, the term "lactic acid" refers to L-lactic acid, the form of lactic acid produced in animals. Some bacteria produce a different form, called [[D-Lactate|D-lactic acid]]. There is evidence that lactic acid in animals may be an important fuel for myocardial [[energy metabolism]].<ref>{{Cite journal|last=Chatham|first=John C|date=2002-07-15|title=Lactate – the forgotten fuel!|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290415/|journal=The Journal of Physiology|volume=542|issue=Pt 2|pages=333|doi=10.1113/jphysiol.2002.020974|issn=0022-3751|pmc=2290415|pmid=12122132}}</ref> | '''Lactic acid''' is a biologically important acid and a by-product of anaerobic metabolism. The conjugate base of lactic acid is called '''lactate'''. Most of the time, the term "lactic acid" refers to L-lactic acid, the form of lactic acid produced in animals. Some bacteria produce a different form, called [[D-Lactate|D-lactic acid]]. There is evidence that lactic acid in animals may be an important fuel for myocardial [[energy metabolism]].<ref>{{Cite journal|last=Chatham|first=John C|date=2002-07-15|title=Lactate – the forgotten fuel!|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290415/|journal=The Journal of Physiology|volume=542|issue=Pt 2|pages=333|doi=10.1113/jphysiol.2002.020974|issn=0022-3751|pmc=2290415|pmid=12122132}}</ref> | ||
== In human disease == | |||
=== ME/CFS === | |||
Elevated blood lactate has been found in both resting ME/CFS patients<ref name=":0">{{Cite journal|last=Ghali|first=Alaa|last2=Lacout|first2=Carole|last3=Ghali|first3=Maria|last4=Gury|first4=Aline|last5=Beucher|first5=Anne-Berengere|last6=Lozac’h|first6=Pierre|last7=Lavigne|first7=Christian|last8=Urbanski|first8=Geoffrey|date=2019-12-11|title=Elevated blood lactate in resting conditions correlate with post-exertional malaise severity in patients with Myalgic encephalomyelitis/Chronic fatigue syndrome|url=https://www.nature.com/articles/s41598-019-55473-4|journal=Scientific Reports|language=en|volume=9|issue=1|pages=1–9|doi=10.1038/s41598-019-55473-4|issn=2045-2322}}</ref> and following exertion. ME/CFS patients with higher elevated lactate at rest may have more severe post-exertional malaise after activity.<ref name=":0" /> | |||
== See also == | == See also == | ||
Revision as of 06:18, December 13, 2019
Lactic acid is a biologically important acid and a by-product of anaerobic metabolism. The conjugate base of lactic acid is called lactate. Most of the time, the term "lactic acid" refers to L-lactic acid, the form of lactic acid produced in animals. Some bacteria produce a different form, called D-lactic acid. There is evidence that lactic acid in animals may be an important fuel for myocardial energy metabolism.[1]
In human disease[edit | edit source]
ME/CFS[edit | edit source]
Elevated blood lactate has been found in both resting ME/CFS patients[2] and following exertion. ME/CFS patients with higher elevated lactate at rest may have more severe post-exertional malaise after activity.[2]
See also[edit | edit source]
Learn more[edit | edit source]
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References[edit | edit source]
- ↑ Chatham, John C (July 15, 2002). "Lactate – the forgotten fuel!". The Journal of Physiology. 542 (Pt 2): 333. doi:10.1113/jphysiol.2002.020974. ISSN 0022-3751. PMC 2290415. PMID 12122132.
- ↑ 2.0 2.1 Ghali, Alaa; Lacout, Carole; Ghali, Maria; Gury, Aline; Beucher, Anne-Berengere; Lozac’h, Pierre; Lavigne, Christian; Urbanski, Geoffrey (December 11, 2019). "Elevated blood lactate in resting conditions correlate with post-exertional malaise severity in patients with Myalgic encephalomyelitis/Chronic fatigue syndrome". Scientific Reports. 9 (1): 1–9. doi:10.1038/s41598-019-55473-4. ISSN 2045-2322.
