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Lactate dehydrogenase
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'''Lactate dehydrogenase''' (LDH) converts [[lactic acid]] to [[pyruvate]] and back. Increased serum concentrations of LDH have been found in ME patients during the acute phase.<ref name="Fegan1983">{{Citation | last = Fegan | first1 = KG | authorlink1 = K G Fegan | last2 = Behan | first2 = PO | authorlink2 = Peter Behan | last3 = Bell | first3 = EJ | authorlink3 = Eleanor Bell | title = Myalgic encephalomyelitis--report of an epidemic. | journal =J R Coll Gen Pract | volume = 33 | issue = 251 | pages = 335-337 | date = Jun 1983 | pmid = 6310104 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972867/ }}</ref> Abnormally high LDH was found in patients of the [[1955 Royal Free Hospital outbreak]].<ref name=":02">{{Cite journal | last = Ramsay | first = A. Melvin | date = November 1978 | title = 'Epidemic neuromyasthenia' 1955-1978|url=https://www.ncbi.nlm.nih.gov/pubmed/746017|journal=Postgraduate Medical Journal|volume=54 | pages = 718-721|via=}}</ref> One study on 579 CDC-criteria CFS patients found lower levels of LDH relative to controls.<ref>{{Cite journal | title = Clinical Laboratory Test Findings in Patients With Chronic Fatigue Syndrome | date = 1995-01-09|url=https://doi.org/10.1001/archinte.1995.00430010105014|journal=Archives of Internal Medicine|volume=155|issue=1 | pages = 97β103 | last = Bates | first = David W. | last2 = Buchwald | first2 = Dedra | last3 = Lee | first3 = Joshua | last4 = Kith | first4 = Phalla | last5 = Doolittle | first5 = Teresa | last6 = Rutherford | first6 = Cynthia | last7 = Churchill | first7 = W. Hallowell | last8 = Schur | first8 = Peter H. | last9 = Wener | first9 = Mark | last10 = Wybenga | first10 = Donald | last11 = Winkelman | first11 = James|doi=10.1001/archinte.1995.00430010105014|issn=0003-9926}}</ref> ==See also== *[[Muscle fatigability]] *[[NAD+]] ==Read more== *[https://en.wikipedia.org/wiki/Lactate_dehydrogenase Lactate dehydrogenase], Wikipedia ==References== [[Category:Genes]] {{Reflist}} [[Category:Enzymes]]
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