Kynurenine: Difference between revisions
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'''Kynurenine''' is an [[amino acid]] that is produced in the body by [[tryptophan]] | '''Kynurenine''' is an [[amino acid]] that is produced in the body by the metabolism of the essential amino acid [[tryptophan]].<ref>{{Cite web|url=https://www.merriam-webster.com/medical/kynurenine|title=Medical Definition of KYNURENINE|website=www.merriam-webster.com|language=en|access-date=2019-11-30}}</ref><ref>{{Cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/Kynurenine|title=Kynurenine|last=National Center for Biotechnology Information|first=|authorlink=|last2=|first2=|authorlink2=|date=|website=PubChem Database|language=en|archive-url=|archive-date=|dead-url=|access-date=2020-01-19}}</ref> | ||
== ME/CFS == | |||
The Open Medicine Foundation's [[ME/CFS Severely Ill, Big Data Study|ME/CFS Severely Ill Big Data Study]] found that patients in the study group with severe ME had one of several defects involving the [[Indoleamine 2,3-dioxygenase|IDO2]] gene, which affected tryptophan - kynurenine metabolism.<ref name="Phair2019" /> This lead to the [[Metabolic trap|Metabolic Trap]] theory.<ref name="Phair2019">{{Cite journal|last=Phair|first=Robert D.|author-link=Robert Phair|last2=Davis|first2=Ronald W.|author-link2=Ron Davis|last3=Kashi|first3=Alex A.|author-link3=Alex Kashi|author-link4=|author-link5=|author-link6=|date=2019|title=The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS|url=https://www.mdpi.com/2075-4418/9/3/82|journal=Diagnostics|language=en|volume=9|issue=3|pages=82|doi=10.3390/diagnostics9030082|quote=|via=}}</ref> | |||
==Learn more== | ==Learn more== | ||
*[https://pubchem.ncbi.nlm.nih.gov/compound/Kynurenine Kynurenine] - PubChem | |||
*[https://pubchem.ncbi.nlm.nih.gov/compound/L-Kynurenine L-Kynurenine] - PubChem | |||
==See also== | ==See also== | ||
Revision as of 14:29, January 19, 2020
 | This article is a stub. |
Kynurenine is an amino acid that is produced in the body by the metabolism of the essential amino acid tryptophan.[1][2]
ME/CFS[edit | edit source]
The Open Medicine Foundation's ME/CFS Severely Ill Big Data Study found that patients in the study group with severe ME had one of several defects involving the IDO2 gene, which affected tryptophan - kynurenine metabolism.[3] This lead to the Metabolic Trap theory.[3]
Learn more[edit | edit source]
- Kynurenine - PubChem
- L-Kynurenine - PubChem
See also[edit | edit source]
References[edit | edit source]
- ↑ "Medical Definition of KYNURENINE". www.merriam-webster.com. Retrieved November 30, 2019.
- ↑ National Center for Biotechnology Information. "Kynurenine". PubChem Database. Retrieved January 19, 2020. Cite has empty unknown parameter:
|dead-url=(help) - ↑ 3.0 3.1 Phair, Robert D.; Davis, Ronald W.; Kashi, Alex A. (2019). "The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS". Diagnostics. 9 (3): 82. doi:10.3390/diagnostics9030082.
