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Kynurenine
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==Potential benefits== Kynurenine might be beneficial to ME/CFS patients; the Open Medicine Foundation's kynurenine trial aims to investigate this. {{Quote frame|Suppose that some brain cells in a particular brain nucleus are in the IDO metabolic trap. This means that in those cells the concentration of tryptophan is too high, and the concentration of kynurenine is too low. Supplying an outside source of kynurenine, as Dr. Bergquist proposes, could conceivably solve part of the problem by allowing those brain cells to make the neuroactive metabolites of kynurenine that they cannot make if the metabolic trap has been sprung. So, the clinical trial might improve symptoms caused by too little kynurenine or too little kynurenic acid, a known neuroprotectant. Dr. Bergquist's expertly designed clinical trial of kynurenine in ME/CFS to improve brain fog, memory, and headache is both important and timely.<ref name=OMF26May2020 /> | author = Robert Phair | date = May 26, 2020 | title = Kynurenine and the Metabolic Trap Hypothesis|source=}}
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