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Kynurenine
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==ME/CFS == The [[Open Medicine Foundation]]'s [[ME/CFS Severely Ill, Big Data Study]] found that patients in the study group with [[Severe and very severe ME|severe ME]] had one of several defects involving the [[Indoleamine-2,3-dioxygenase 2|IDO2]] gene, which affected tryptophan - kynurenine metabolism.<ref name="Phair2019" /> This lead to the [[Metabolic trap|Metabolic Trap]] theory.<ref name="Phair2019">{{Cite journal | last = Phair | first = Robert D. | authorlink = Robert Phair | last2 = Davis | first2 = Ronald W. | authorlink2 = Ron Davis | last3 = Kashi | first3 = Alex A. | authorlink3 = Alex Kashi | authorlink4 = | authorlink5 = | authorlink6 = | date = 2019 | title=The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS|url=https://www.mdpi.com/2075-4418/9/3/82|journal=Diagnostics|language=en|volume=9|issue=3 | pages = 82|doi=10.3390/diagnostics9030082|quote=|via=}}</ref> Kynurenine is a neuroprotectant and a potential treatment. A clinical trial has been announced to investigate the effects of kynurenine, [[Robert Phair]] has stated the potential benefits of kynurenine in people with ME/CFS that may be: * reduced [[cognitive dysfunction|brain fog]] * reduced [[Memory problems|memory impairment]], and * improvements in [[headache]] symptoms<ref name=OMF26May2020>{{Cite web|url=https://www.omf.ngo/2020/05/26/omf-announces-new-treatment-trial/ | title = OMF Announces New Treatment Trial | date = 2020-05-26 | last = Open Medicine Foundation | authorlink = Open Medicine Foundation|language=en-US|access-date=2020-07-03}}</ref>
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