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Karl Morten
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==Projects funded by ME Association== ===Mitochondrial function in Neutrophils and Monocytes=== In March 2016 [[The ME Association]] announced it would fund Dr Morten and Professor Joanna Poulton to to assess mitochondrial function in [[Neutrophil]] and [[Monocyte cells]] from ME/CFS patients.<ref>{{Cite web | url = https://www.meassociation.org.uk/2016/03/me-association-to-fund-fourth-study-into-the-role-of-the-mitochondria-in-mecfs-10-march-2016/ | title = ME Association to fund fourth study into the role of the mitochondria in ME/CFS {{!}} 10 March 2016|language=en-GB|access-date=2019-08-16}}</ref> <blockquote>"The pilot study will set up the tests required to assess mitochondrial function in blood samples from ME/CFS patients. This will make the blood tests more globally accessible to a wide range of researchers allowing a more universal validation of the findings of Booth/Myhill."<ref>{{Cite journal | last = Myhill | first = Sarah | authorlink = Sarah Myhill | last2 = Booth | first2 = Norman E. | authorlink2 = Norman Booth | last3 = McLaren-Howard | first3 = John | authorlink3 = John McLaren-Howarddate=2009-01-15 | title = Chronic fatigue syndrome and mitochondrial dysfunction | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680051/|journal=International Journal of Clinical and Experimental Medicine|volume=2|issue=1|pages=1β16|issn=1940-5901|pmc=2680051|pmid=19436827|quote=|via=}}</ref></blockquote> ===ME Association Christmas Appeal 2016=== The ME Association Christmas Appeal for 2016 sought to raise Β£50,000 to fund research by a team led by Dr Morten to study [[metabolomics]] in patients.<ref>[http://me-pedia.org/wiki/Karl_Morten MEA Xmas Appeal Announcment November 2016]</ref> Dr Morten will work alongside scientists from Oxford and Newcastle Universities including Prof [[Julia Newton]]. Part of the team is ME/CFS patient Jamie Strong. <ref>[http://www.meassociation.org.uk/2016/11/make-me-better-why-our-christmas-appeal-has-got-personal-for-jamie-23-november-2016/ Make ME Better! | Why our Christmas Appeal has got personal for Jamie | 23 November 2016]</ref> The research will focus on the chemical clues left behind by mitochondrial cells and follow on from the work of Dr [[Robert Naviaux]] in this area.<ref>[http://www.pnas.org/content/113/37/E5472 Metabolic features of chronic fatigue syndrome: R Naviaux et al]</ref> 300 blood samples will analysed, many from the [[UK ME/CFS biobank]]. ===Mitochondrial Energy Score test validation study === In 2019, Karl Morten and colleagues published their attempt to replicate the Mitochondrial Energy Score test provided by Dr [[Sarah Myhill]], [[Norman Booth]] and [[John McLaren-Howard]] using samples from 10 patients who met the Canadian Consensus Criteria fire ME/CFS, and 13 healthy controls.<ref name="Morten2019" /> They were unable to confirm the [[Mitochondrion|mitochondrial]] findings. Myhill responded to the publication, outlining significant factors that may have affected the results including the freezing of samples, and criticized the publication for incorrectly stating that the Mitochondrial Energy Score had been described as a diagnostic test for [[CFS/ME]].<ref name="Myhill2019">{{Cite web | url = https://www.drmyhill.co.uk/wiki/Response_to_the_paper_%27Assessing_cellular_energy_dysfunction_in_CFS/ME_using_a_commercially_available_laboratory_test%27_by_Cara_Tomas_et_al | title = Response to the paper 'Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test' by Cara Tomas et al | last = Myhill | first = Sarah | authorlink = Sarah Myhill | date = Aug 2019 | website = drmyhill.co.uk|archive-url=|archive-date=|url-status=|access-date=2019-08-16}}</ref>
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