Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Karl Morten
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
[[File:Karl Morten.png|200px|thumb|right|Source:obs-gyn.ox.ac.uk]] '''Karl J. Morten''', PhD, is a senior researcher and laboratory manager at the Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford University, [[United Kingdom]].<ref>{{Cite web | url = https://www.wrh.ox.ac.uk/team/karl-morten | title = Karl Morten — Nuffield Department of Women's & Reproductive Health | last = | first = | authorlink = | date = | website = wrh.ox.ac.uk|archive-url=|archive-date=|url-status=|access-date=2020-09-27}}</ref> His work focuses on understanding the role of [[Mitochondrion|mitochondria]] in health and disease. Some of his work has been funded by [[The ME Association]].<ref>{{cite web | url = http://www.meassociation.org.uk/2016/05/me-associations-contributions-towards-mitochondrial-muscle-research-in-mecfs-17-may-2016/ | date = 2016-05-17 | title = ME Association: contributions towards mitochondrial muscle research|website=[[The ME Association]]}}</ref> ==Projects funded by ME Association== ===Mitochondrial function in Neutrophils and Monocytes=== In March 2016 [[The ME Association]] announced it would fund Dr Morten and Professor Joanna Poulton to to assess mitochondrial function in [[Neutrophil]] and [[Monocyte cells]] from ME/CFS patients.<ref>{{Cite web | url = https://www.meassociation.org.uk/2016/03/me-association-to-fund-fourth-study-into-the-role-of-the-mitochondria-in-mecfs-10-march-2016/ | title = ME Association to fund fourth study into the role of the mitochondria in ME/CFS {{!}} 10 March 2016|language=en-GB|access-date=2019-08-16}}</ref> <blockquote>"The pilot study will set up the tests required to assess mitochondrial function in blood samples from ME/CFS patients. This will make the blood tests more globally accessible to a wide range of researchers allowing a more universal validation of the findings of Booth/Myhill."<ref>{{Cite journal | last = Myhill | first = Sarah | authorlink = Sarah Myhill | last2 = Booth | first2 = Norman E. | authorlink2 = Norman Booth | last3 = McLaren-Howard | first3 = John | authorlink3 = John McLaren-Howarddate=2009-01-15 | title = Chronic fatigue syndrome and mitochondrial dysfunction | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680051/|journal=International Journal of Clinical and Experimental Medicine|volume=2|issue=1|pages=1–16|issn=1940-5901|pmc=2680051|pmid=19436827|quote=|via=}}</ref></blockquote> ===ME Association Christmas Appeal 2016=== The ME Association Christmas Appeal for 2016 sought to raise £50,000 to fund research by a team led by Dr Morten to study [[metabolomics]] in patients.<ref>[http://me-pedia.org/wiki/Karl_Morten MEA Xmas Appeal Announcment November 2016]</ref> Dr Morten will work alongside scientists from Oxford and Newcastle Universities including Prof [[Julia Newton]]. Part of the team is ME/CFS patient Jamie Strong. <ref>[http://www.meassociation.org.uk/2016/11/make-me-better-why-our-christmas-appeal-has-got-personal-for-jamie-23-november-2016/ Make ME Better! | Why our Christmas Appeal has got personal for Jamie | 23 November 2016]</ref> The research will focus on the chemical clues left behind by mitochondrial cells and follow on from the work of Dr [[Robert Naviaux]] in this area.<ref>[http://www.pnas.org/content/113/37/E5472 Metabolic features of chronic fatigue syndrome: R Naviaux et al]</ref> 300 blood samples will analysed, many from the [[UK ME/CFS biobank]]. ===Mitochondrial Energy Score test validation study === In 2019, Karl Morten and colleagues published their attempt to replicate the Mitochondrial Energy Score test provided by Dr [[Sarah Myhill]], [[Norman Booth]] and [[John McLaren-Howard]] using samples from 10 patients who met the Canadian Consensus Criteria fire ME/CFS, and 13 healthy controls.<ref name="Morten2019" /> They were unable to confirm the [[Mitochondrion|mitochondrial]] findings. Myhill responded to the publication, outlining significant factors that may have affected the results including the freezing of samples, and criticized the publication for incorrectly stating that the Mitochondrial Energy Score had been described as a diagnostic test for [[CFS/ME]].<ref name="Myhill2019">{{Cite web | url = https://www.drmyhill.co.uk/wiki/Response_to_the_paper_%27Assessing_cellular_energy_dysfunction_in_CFS/ME_using_a_commercially_available_laboratory_test%27_by_Cara_Tomas_et_al | title = Response to the paper 'Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test' by Cara Tomas et al | last = Myhill | first = Sarah | authorlink = Sarah Myhill | date = Aug 2019 | website = drmyhill.co.uk|archive-url=|archive-date=|url-status=|access-date=2019-08-16}}</ref> == Notable studies == * 2019, Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test<ref name="Morten2019">{{Cite journal | last = Morten | first = Karl J. | authorlink = Karl Morten | last2 = Newton | first2 = Julia L. | authorlink2 = Julia Newton | last3 = Joanna L. Elson | authorlink3 = Joanna Elson | last4 = Potter | first4 = Michelle | authorlink4 = Michelle Potter | last5 = Lodge | first5 = Tiffany A. | authorlink5 = Tiffany Lodge | last6 = Tomas | first6 = Cara | authorlink6 = Cara Tomas | date = 2019-08-07 | title = Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test | url = https://www.nature.com/articles/s41598-019-47966-z|journal=Scientific Reports|language=en|volume=9|issue=1|pages=1–9|doi=10.1038/s41598-019-47966-z|issn=2045-2322|quote=|via=}}</ref> [https://www.nature.com/articles/s41598-019-47966-z (Full text)] * 2018, A new approach to find [[Diagnostic biomarker|biomarkers]] in [[ME/CFS|chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)]] by single-cell Raman micro-spectroscopy<ref>{{Cite journal | last = Xu | first = Jiabao | last2 = Potter | first2 = Michelle | last3 = Tomas | first3 = Cara | authorlink3 = Cara Tomas | last4 = Elson | first4 = Jo | last5 = Morten | first5 = Karl | authorlink5 = Karl Morten | last6 = Poulton | first6 = Joanna | last7 = Wang | first7 = Ning | last8 = Jin | first8 = Hanqing | last9 = Hou | first9 = Zhaoxu | date = 2018 | title = A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy | url = https://pubs.rsc.org/en/content/articlelanding/2018/an/c8an01437j/unauth#!divRelatedContent&articles|journal=The Analyst|language=en|volume=|pages=|doi=10.1039/C8AN01437J|issn=0003-2654|via=}}</ref> [https://pubs.rsc.org/en/content/articlelanding/2018/an/c8an01437j/unauth#!divRelatedContent&articles (Abstract)] * 2018, Potential clinical usefulness of gut [[microbiome]] testing in a variety of clinical conditions<ref>{{Cite journal | last = Morten | first = Karl J. | authorlink = Karl Morten | last2 = Staines-Urias | first2 = Eleonora | authorlink2 = | last3 = Kenyon | first3 = Julian | date = Dec 2018 | title = Potential clinical usefulness of gut microbiome testing in a variety of clinical conditions | url = https://linkinghub.elsevier.com/retrieve/pii/S2452231718300241|journal=Human Microbiome Journal|volume=10|issue= | pages = 6–10|doi=10.1016/j.humic.2018.08.003|issn=2452-2317|quote=|via=}}</ref> [https://www.sciencedirect.com/science/article/pii/S2452231718300241 (Full text)] * 2021, Relationship between cardiopulmonary, mitochondrial and autonomic nervous system function improvement after an individualised activity programme upon Chronic Fatigue Syndrome patients<ref>{{Cite journal | last = Kujawski | first = Sławomir | authorlink = | last2 = Cossington | first2 = Jo | authorlink2 = | last3 = Słomko | first3 = Joanna | authorlink3 = | last4 = Zawadka-Kunikowska | first4 = Monika | authorlink4 = | last5 = Tafil-Klawe | first5 = Małgorzata | authorlink5 = | last6 = Klawe | first6 = Jacek | authorlink6 = | last7 = Buszko | first7 = Katarzyna | last8 = Jakovljevic | first8 = Djordje | last9 = Kozakiewicz | first9 = Mariusz | last10 = Morten | first10 = Karl J. | authorlink10 = Karl Morten | last11 = Dawes | first11 = Helen | author-link11 = | last12 = Strong | first12 = James W.L. | author-link12 = | last13 = Murovska | first13 = Modra | author-link13 = Modra Murovska | last14 = Van Oosterwijck | first14 = Jessica | author-link14 = Jessica Van Oosterwijck | last15 = Estevez-Lopez | first15 = Fernando | author-link15 = | last16 = Newton | first16 = Julia L. | authorlink16 = Julia Newton | last17 = Hodges | first17 = Lynette | author-link17 = Lynette Hodges | last18 = Zalewski | first18 = Paweł | author-link18 = Paweł Zalewski | last19 = European Network on ME/CFS | first19 = (EUROMENE) | author-link19 = EUROMENE | date = 2021-04-06 | title = Relationship between Cardiopulmonary, Mitochondrial and Autonomic Nervous System Function Improvement after an Individualised Activity Programme upon Chronic Fatigue Syndrome Patients | url = https://www.mdpi.com/2077-0383/10/7/1542|journal=Journal of Clinical Medicine|language=en|volume=10|issue=7|pages=1542|doi=10.3390/jcm10071542|issn=2077-0383|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.mdpi.com/2077-0383/10/7/1542/htm (Full text)] ==Talks and interviews== *2016, [https://www.youtube.com/watch?v=L0vxtU0nDlA Talk on Research into Mitochondria & M.E. by Dr Karl Morten], [http://www.meassociation.org.uk/wp-content/uploads/MEA-OMEGA-talk-May-10th.pdf (Slides from the Lecture)] *Dec 2018, [https://www.youtube.com/watch?v=Yb3wbQt1BCc Developments in Understanding the Science Behind ME/CFS] ==Online presence== *[https://www.researchgate.net/profile/Karl_Morten/publications ResearchGate: Karl Morten] *[https://pubmed.ncbi.nlm.nih.gov/?term=Morten+K&cauthor_id=31861543 Pubmed] *[https://www.wrh.ox.ac.uk/team/karl-morten Oxford University: Karl Morten] *[https://www.mortengroup.org.uk/ The Morten Group] ME/CFS research ==Learn more== *[https://www.s4me.info/threads/patient-representative-reports-from-dr-karl-mortens-collaborative-group-oxford-uk.9402/ Patient Representative Reports from Dr Karl Morten's collaborative group], posted on the [[Science for ME]] forum *[http://www.meassociation.org.uk/2016/11/make-me-better-0ur-biggest-ever-christmas-appeal-starts-today-9-november-2016/ ME Association Christmas Appeal 2016] ==See also== *[[L-form bacteria]] *[[Julia Newton]] *[[Metabolomics]] *[[Mitochondrion]] *[[Neutrophil]] *[[Robert Naviaux]] ==References== {{Reflist}} [[Category:Researchers]] [[Category:UK researchers]]
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Templates used on this page:
Template:Cite journal
(
edit
)
Template:Cite web
(
edit
)
Template:Main other
(
edit
)
Template:Reflist
(
edit
)
Module:Check for unknown parameters
(
edit
)
Module:Citation/CS1
(
edit
)
Module:Citation/CS1/COinS
(
edit
)
Module:Citation/CS1/Configuration
(
edit
)
Module:Citation/CS1/Date validation
(
edit
)
Module:Citation/CS1/Identifiers
(
edit
)
Module:Citation/CS1/Utilities
(
edit
)
Module:Citation/CS1/Whitelist
(
edit
)
Module:No globals
(
edit
)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs