John Chia

Dr. John K. S. Chia is an infectious disease doctor with a medical practice in Torrance, California. Dr. Chia became heavily involved in research and clinical care of myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) patients after his son Andrew Chia became ill with CFS in 1997. He has published several papers on infectious causes of ME and CFS, including evidence of involvement of enteroviruses such as coxsackie B and echovirus, other viruses, such as parvovirus B19, as well as, bacteria, such as Chlamydia pneumoniae. In addition to his clinical work, he runs his own enterovirus research laboratory and is on the board of directors of the Enterovirus Foundation.

Dr. Chia has performed clinical trials in an attempt to find treatment for patients with ME and CFS. His treatment attempts have focused on the use of antiviral compounds such as amantadine, ribavirin, and lamivudine in addition to immune modulators such as interferon and the plant compound oxymatrine. Towards this end, he and his son, a pharmacist, have developed his own proprietary herbal preparation containing oxymatrine and other plant compounds, called Equilibrant.

International Consensus Criteria

Dr. Chia co-authored the 2011 case definition, International Consensus Criteria.

Open Letter to The Lancet

Three open letters to the editor of The Lancet urged the editor to commission a fully independent review of the PACE trial, which the journal had published in 2011. In 2016, Dr. Chia, along with 41 colleagues in the ME/CFS field, signed the second letter. In 2018, Dr. Chia was joined with over 100 signatories.

• 10 February 2016, An open letter to The Lancet, again - Virology blog
• 19 June 2018, An Open Letter to The Lancet, Two Years On

Notable studies

• 2004, Ribavirin and Interferon-α for the Treatment of Patients with Chronic Fatigue Syndrome Associated with Persistent Coxsackievirus B Infection: A Preliminary Observation (Full Text)
• 2005, The role of enterovirus in chronic fatigue syndrome (Full Text)
• 2008, Chronic fatigue syndrome is associated with chronic enterovirus infection of the stomach (Abstract)
• 2015, Poster - Dr Chia's ME/CFS post-mortem brain study: Chronic Enterovirus Infection in a Patient With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) – Clinical, Virologic and Pathological Analysis
• 2015, Functional Dyspepsia and Chronic Gastritis Associated with Enteroviruses (Full Text)

Talks & interviews

• 2008, Dr John Chia, The Role of Enterovirus in ME/CFS, International Symposium on Viruses In CFS 2008
• 2008, Speaker at the 3rd Invest in ME International ME Conference 2008 on Research on the Role of Chronic Enterovirus Infection in CFS/ME DVD available
• 2009, Speaker at the 4th Invest in ME International ME Conference 2009 on Diagnosis and Treatment of chronic enterovirus infection associated with ME/CFS DVD available
• 2010, Speaker at the 5th Invest in ME International ME Conference 2010 on Enteroviruses in ME/CFS, Diagnosis and Treatment DVD available
• 2011, Speaker at the 6th Invest in ME International ME Conference 2011 on Enteroviruses in ME/CFS, Diagnosis and Treatment DVD available
• 2011, Dr John Chia State of Knowledge ME/CFS Research Workshop(Day 2) Review (9 April)
• 2011, Dr John Chia State of Knowledge Workshop on ME/CFS Research (Day 1) Part 1 (7 April)
• 2011, Dr John Chia State of Knowledge Workshop on ME/CFS Research (Day 1) Part 2 (7 April)
• 2011, The Dr. John Chia Interview (8/08): Introduction (6 March)
• 2012, MECFS Alert Episode 38, part 1 - Interview with Dr. John Chia, Part 1 (22 December)
• 2013, MECFS Alert Episode 41, part 4 - Interview with Dr. John Chia, Part 4 (17 February)
• 2013, MECFS Alert Episode 40, part 3 - Interview with Dr. John Chia, Part 3 (30 January)
• 2013, MECFS Alert Episode 39, part 2 - Interview with Dr. John Chia, Part 2 (11 January)
• 2015, Speaker at the 10th Invest in ME International ME Conference 2015 on Enteroviruses and ME/CFS: An Update on Pathogenesis DVD available
• 2016, 12th International IACFS/ME Biennial Clinical and Research Conference, Emerging Science and Clinical Care, Acute and Chronic Enteroviral Infection

Media coverage

• 13 September 2007, Stomach Virus Could Trigger CFS. Enterovirus Found in Many Chronic Fatigue Syndrome Sufferers
• 14 September 2007, Study: Common Stomach Virus Tied to Chronic Fatigue
• 2009, Dr. Chia On Oxymatrine, Autoimmunity, ME/CFS and Fibromyalgia
• 2011, An Interview With Dr. John Chia M.D. Enteroviruses and Chronic Fatigue Syndrome Part II: Persistence, Treatment and the Future
• 2011, An Interview With Dr. John Chia, M.D. Part I
• 2011, Dr Chia's report on the use of interferon to treat ME/CFS
• 2011, Oxymatrine
• February 2013, Hanging Fire – Dr. John Chia

Publications

• 2003, Correspondence in Clinical Infectious Diseases - "Diverse Etiologies for Chronic Fatigue Syndrome"

Online presence

• PubMed
• Website
• Health Rising profile

See also

• Enterovirus
• Non-cytolytic enterovirus
• List of enterovirus infection studies
• Equilibrant

Learn more

• Stanford Medicine page on Dr. John Chia

α α / Α. Greek letter alpha or alfa (a symbol used in science), equivalent to "a".

enterovirus A genus of RNA viruses which typically enter the body through the respiratory or gastrointestinal systems and sometimes spread to the central nervous system or other parts of the body, causing neurological, cardiac, and other damage. Since the first reports of myalgic encephalomyelitis (ME), enteroviruses have been suspected as a cause of ME. Enteroviruses have also been implicated as the cause of Type I diabetes, congestive heart failure, and other conditions. Enteroviruses include poliovirus, coxsackieviruses, and many others. New enteroviruses and new strains of existing enteroviruses are continuously being discovered. (Learn more: viralzone.expasy.org)

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

enterovirus A genus of RNA viruses which typically enter the body through the respiratory or gastrointestinal systems and sometimes spread to the central nervous system or other parts of the body, causing neurological, cardiac, and other damage. Since the first reports of myalgic encephalomyelitis (ME), enteroviruses have been suspected as a cause of ME. Enteroviruses have also been implicated as the cause of Type I diabetes, congestive heart failure, and other conditions. Enteroviruses include poliovirus, coxsackieviruses, and many others. New enteroviruses and new strains of existing enteroviruses are continuously being discovered. (Learn more: viralzone.expasy.org)

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

enterovirus A genus of RNA viruses which typically enter the body through the respiratory or gastrointestinal systems and sometimes spread to the central nervous system or other parts of the body, causing neurological, cardiac, and other damage. Since the first reports of myalgic encephalomyelitis (ME), enteroviruses have been suspected as a cause of ME. Enteroviruses have also been implicated as the cause of Type I diabetes, congestive heart failure, and other conditions. Enteroviruses include poliovirus, coxsackieviruses, and many others. New enteroviruses and new strains of existing enteroviruses are continuously being discovered. (Learn more: viralzone.expasy.org)