International Consensus Criteria: Difference between revisions

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The [[Myalgic Encephalomyelitis]] (ME) '''International Consensus Criteria''' (ICC)<ref name=":0">{{Cite journal|last=Carruthers|first=Bruce M.|author-link=Bruce Carruthers|last2=van de Sande|first2=Marjorie I.|author-link2=Marjorie van de Sande|last3=De Meirleir|first3=Kenny L.|author-link3=Kenny De Meirleir|last4=Klimas|first4=Nancy G.|author-link4=Nancy Klimas|last5=Broderick|first5=Gordon|author-link5=Gordon Broderick|last6=Mitchell|first6=Terry|author-link6=Terry Mitchell|last7=Staines|first7=Donald|author-link7=Donald Staines|last8=Powles|first8=A. C. Peter|author-link8=A C Peter Powles|last9=Speight|first9=Nigel|author-link9=Nigel Speight|last10=Vallings|first10=Rosamund|author-link10=Rosamund Vallings|last11=Bateman|first11=Lucinda|author-link11=Lucinda Bateman|last12=Baumgarten-Austrheim|first12=Barbara|author-link12=Barbara Baumgarten-Austrheim|last13=Bell|first13=David|author-link13=David Bell|last14=Carlo-Stella|first14=Nicoletta|author-link14=Nicoletta Carlo-Stella|last15=Chia|first15=John|author-link15=John Chia|last16=Darragh|first16=Austin|author-link16=Austin Darragh|last17=Jo|first17=Daehyun|author-link17=Daehyun Jo|last18=Lewis|first18=Donald|author-link18=Donald Lewis|last19=Light|first19=Alan|author-link19=Alan Light|last20=Marshall-Gradisnik|first20=Sonya|author-link20=Sonya Marshall-Gradisnik|last21=Mena|first21=Ismael|author-link21=Ismael Mena|last22=Mikovits|first22=Judy|author-link22=Judy Mikovits|last23=Miwa|first23=Kunihisa|author-link23=Kunihisa Miwa|last24=Murovska|first24=Modra|author-link24=Modra Murovska|last25=Pall|first25=Martin|author-link25=Martin Pall|last26=Stevens|first26=Staci|author-link26=Staci Stevens|date=2011-08-22|title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> is a medical case definition that can accurately diagnose [[myalgic encephalomyelitis]] (ME), is a chronic, [[Inflammation|inflammatory]], physically and [[Nervous system|neurologically]] disabling disease. For pediatric and adult cases a diagnosis should be made immediately; there is no need to wait up to 6 months.
[[File:What-is-Myalgic-Encephalomyelitis-ME-ICC.png|frameless|upright=0.75|right|Simplified ME International Consensus Criteria symptoms.]]
The [[myalgic encephalomyelitis|Myalgic Encephalomyelitis]] (ME) '''International Consensus Criteria''' (ICC)<ref name="icc">{{Cite journal | last = Carruthers | first = Bruce M. | authorlink = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | author-link4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | authorlink5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | authorlink6 = Terry Mitchell | last7 = Staines | first7 = Donald | authorlink7 = Donald Staines | last8 = Powles | first8 = A.C. Peter | authorlink8 = A C Peter Powles | last9 = Speight | first9 = Nigel | authorlink9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | authorlink11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | authorlink12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | author-link14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | author-link15 = John Chia | last16 = Darragh | first16 = Austin | author-link16 = Austin Darragh | last17 = Jo | first17 = Daehyun | author-link17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria | url = https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4 | pages = 327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> is a medical case definition that can accurately diagnose [[myalgic encephalomyelitis]] (ME), is a chronic, [[Inflammation|inflammatory]], physically and [[Nervous system|neurologically]] disabling disease. For pediatric and adult cases a diagnosis should be made immediately; there is no need to wait up to 6 months.


==Authors==
==Authors==
[[Bruce Carruthers]], [[Marjorie van de Sande]], [[Kenny de Meirleir]], [[Nancy Klimas]], [[Gordon Broderick]], [[Terry Mitchell]], [[Donald Staines]], [[A C Peter Powles]], [[Nigel Speight]], [[Rosamund Vallings]], [[Lucinda Bateman]], [[Barbara Baumgarten-Austrheim]], [[David Bell]], [[Nicoletta Carlo-Stella]], [[John Chia]], [[Austin Darragh]], [[Daehyun Jo]], [[Donald Lewis]], [[Alan Light]], [[Sonya Marshall-Gradisnik]], [[Ismael Mena]], [[Judy Mikovits]], [[Kunihisa Miwa]], [[Modra Murovska]], [[Martin Pall]], and [[Staci Stevens]]<ref name=":0" />
[[Bruce Carruthers]], [[Marjorie van de Sande]], [[Kenny de Meirleir]], [[Nancy Klimas]], [[Gordon Broderick]], [[Terry Mitchell]], [[Donald Staines]], [[A C Peter Powles]], [[Nigel Speight]], [[Rosamund Vallings]], [[Lucinda Bateman]], [[Barbara Baumgarten-Austrheim]], [[David Bell]], [[Nicoletta Carlo-Stella]], [[John Chia]], [[Austin Darragh]], [[Daehyun Jo]], [[Donald Lewis]], [[Alan Light]], [[Sonya Marshall-Gradisnik]], [[Ismael Mena]], [[Judy Mikovits]], [[Kunihisa Miwa]], [[Modra Murovska]], [[Martin Pall]], and [[Staci Stevens]]<ref name="icc" />


==Criteria==
==Criteria==
A patient will meet the criteria for [[Myalgic encephalomyelitis|Myalgic Encephalomyelitis]] if they have:
A patient will meet the criteria for [[myalgic encephalomyelitis|Myalgic Encephalomyelitis]] if they have:


'''A''' - [[Postexertional neuroimmune exhaustion]]
'''A''' - [[Postexertional neuroimmune exhaustion]]
Line 14: Line 15:
# [[Pain]] &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;           
# [[Pain]] &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;           
# [[Sleep dysfunction|Sleep Disturbance]] &nbsp; &nbsp; &nbsp;
# [[Sleep dysfunction|Sleep Disturbance]] &nbsp; &nbsp; &nbsp;
# [[Neurosensory]], [[perceptual distortion|Perceptual]] and [[motor problems|Motor Disturbances]]
# [[:Category:Cognitive signs and symptoms|Neurosensory]], [[perceptual distortion|Perceptual]] and [[motor problems|Motor Disturbances]]


'''C''' - at least ONE '''[[Immune system|immune]]/[[Gastrointestinal|gastro-intestinal]]/genitourinary impairment''' from THREE categories:
'''C''' - at least ONE '''[[Immune system|immune]]/[[Gastrointestinal|gastro-intestinal]]/genitourinary impairment''' from THREE categories:
# [[Flu-like symptoms]] may be recurrent or chronic and typically activate or worsen with [[exertion]]   
# [[Flu-like symptoms]] may be recurrent or chronic and typically activate or [[Post-exertional symptom exacerbation|worsen with exertion]]   
# Susceptibility to [[virus|viral infections]] with prolonged recovery periods   
# [[susceptibility to viruses|Susceptibility to viral infections]] with prolonged recovery periods   
# [[Gastrointestinal system|Gastro-intestinal]] tract 
# [[Gastrointestinal system|Gastro-intestinal tract disturbances]]
# Genitourinary &nbsp; &nbsp;
# [[:Category:Genitourinary signs and symptoms|Genitourinary disturbances]]
# [[Hypersensitivity|Sensitivities]] to food, medications, odors or chemicals, and
# [[Hypersensitivity|Sensitivities]] to [[Food intolerance|food]], [[Medicine sensitivities|medications]], [[Odor sensitivities|odors]] or [[multiple chemical sensitivity|chemicals]], and


'''D''' - at least ONE '''[[Metabolic|energy metabolism]]/[[Ion transportation|ion transport]] impairment''' symptom.
'''D''' - at least ONE '''[[Metabolic|energy metabolism]]/[[Ion transportation|ion transport]] impairment''' symptom.
# [[Cardiovascular system|Cardiovascular]] &nbsp;
# [[Cardiovascular system|Cardiovascular]] &nbsp;
# [[Respiratory]] &nbsp; &nbsp;
# [[Breathing problems in ME/CFS|Respiratory]] &nbsp; &nbsp;
# Loss of [[Body temperature|thermostatic stability]]
# [[thermostatic instability|Loss of thermostatic stability]]
# [[Temperature sensitivity|Intolerance of extremes of temperature]] &nbsp;
# [[Temperature sensitivity|Intolerance of extremes of temperature]] &nbsp;
<hr />
<hr />


===A. [[Postexertional neuroimmune exhaustion]] (PENE pen’-e): Compulsory===
{| class="wikitable left"
|-
| style="background-color: peachpuff;color:black;text-shadow:none" |
|<h3>[[Postexertional neuroimmune exhaustion]] (PENE pen’-e): Compulsory</h3>
|-
| style="background-color: peachpuff;color:black;text-shadow:none" |A.
|
This cardinal feature is a [[pathological inability to produce sufficient energy on demand with prominent symptoms primarily in the neuroimmune regions]]. Characteristics are as follows:


This cardinal feature is a pathological inability to produce sufficient energy on demand with prominent symptoms primarily in the neuroimmune regions. Characteristics are as follows:
: 1. [[Marked, rapid physical and/or cognitive fatigability in response to exertion]], which may be minimal such as activities of daily living or simple mental tasks, can be debilitating and cause a [[relapse]].
 
: 2. [[Post-exertional symptom exacerbation |Postexertional symptom exacerbation]]: e.g. acute [[flu-like symptoms]], pain and worsening of other symptoms.
: 1. Marked, rapid physical and/or cognitive fatigability in response to exertion, which may be minimal such as activities of daily living or simple mental tasks, can be debilitating and cause a relapse.
: 3. [[Post-exertional exhaustion: immediate or delayed|Postexertional exhaustion]] may occur immediately after activity or be delayed by hours or days.
: 2. Postexertional symptom exacerbation: e.g. acute flu-like symptoms, pain and worsening of other symptoms.
: 4. [[Recovery period is prolonged, usually taking 24 hours or longer|Recovery period is prolonged, usually taking 24h or longer]]. A relapse can last days, weeks or longer.
: 3. Postexertional exhaustion may occur immediately after activity or be delayed by hours or days.
: 5. [[Lack of stamina|Low threshold of physical and mental fatigability]] (lack of stamina) results in a [[Greatly lowered ability to do activities that were usual before the illness|substantial reduction in pre-illness activity level]].
: 4. Recovery period is prolonged, usually taking 24 h or longer. A relapse can last days, weeks or longer.
: 5. Low threshold of physical and mental fatigability ([[lack of stamina]]) results in a substantial reduction in pre-illness activity level.
 
Operational notes: ''For a diagnosis of ME, symptom severity must result in a significant reduction of a patient’s premorbid activity level. Mild (an approximate 50% reduction in pre-illness activity level), moderate (mostly housebound), severe (mostly bedridden) or very severe (totally bedridden and need help with basic functions). There may be marked fluctuation of symptom severity and hierarchy from day to day or hour to hour. Consider activity, context and interactive effects. Recovery time: e.g. Regardless of a patient’s recovery time from reading for ½ hour, it will take much longer to recover from grocery shopping for ½ hour and even longer if repeated the next day – if able. Those who rest before an activity or have adjusted their activity level to their limited energy may have shorter recovery periods than those who do not pace their activities adequately. Impact: e.g. An outstanding athlete could have a 50% reduction in his/her pre-illness activity level and is still more active than a sedentary person.''
 
===B. Neurological impairments===


Operational notes: ''For a diagnosis of ME, symptom severity must result in a [[substantial reduction or impairment in the ability to engage in pre-illness levels of occupational, educational, social, or personal activities|significant reduction of a patient's premorbid activity level]]. [[Mild myalgic encephalomyelitis or chronic fatigue syndrome|Mild]] (an approximate 50% reduction in pre-illness activity level), [[Moderate myalgic encephalomyelitis or chronic fatigue syndrome|moderate]] (mostly housebound), [[severe myalgic encephalomyelitis or chronic fatigue syndrome|severe]] (mostly bedridden) or [[very severe myalgic encephalomyelitis or chronic fatigue syndrome|very severe]] (totally bedridden and need help with basic functions). There may be marked [[fluctuating illness#fluctuating symptoms|fluctuation of symptom severity and hierarchy]] from day to day or hour to hour. Consider activity, context and interactive effects. Recovery time: e.g. Regardless of a patient’s recovery time from reading for ½ hour, it will take much longer to recover from grocery shopping for ½ hour and even longer if repeated the next day – if able. Those who [[rest]] before an activity or have adjusted their activity level to their [[energy limit|limited energy]] may have shorter recovery periods than those who do not [[pacing|pace their activities]] adequately. Impact: e.g. An outstanding athlete could have a [[substantial reduction or impairment in the ability to engage in pre-illness levels of occupational, educational, social, or personal activities|50% reduction in his/her pre-illness activity level]] and is still more active than a sedentary person.''
|-
| style="background-color: palegreen;color:black;text-shadow:none" |
|<h3>Neurological impairments</h3>
|-
| style="background-color: palegreen;color:black;text-shadow:none" |B.
|
At least one symptom from three of the following four symptom categories
At least one symptom from three of the following four symptom categories


====1. Neurocognitive impairments====
<h4>1. Neurocognitive impairments</h4>
 
:a. Difficulty processing information: [[slowed thought]], [[attention deficit|impaired concentration]] e.g. [[confusion]], [[disorientation]], cognitive overload, difficulty with making decisions, [[slowed speech]], acquired or exertional [[dyslexia]]
:b. Short-term memory loss: e.g. difficulty remembering what one wanted to say, what one was saying, retrieving words, recalling information, poor working memory


====2. [[Pain]]====
:a.[[difficulty thinking|Difficulty processing information]]: [[slowed thought]], [[attention deficit|impaired concentration]] e.g. [[confusion]], [[disorientation]], cognitive overload, difficulty with making decisions, [[Speech difficulties|slowed speech]], acquired or exertional [[dyslexia]]
:b. [[Memory problems|Short-term memory loss]]: e.g. difficulty remembering what one wanted to say, what one was saying, [[word-finding problems|retrieving words]], recalling information, [[poor working memory]]


:a.[[Headache]]s: e.g. chronic, generalized headaches often involve aching of the eyes, behind the eyes or back of the head that may be associated with cervical muscle tension; [[migraine]]; tension headaches
<h4>2. [[Pain]]</h4>
:b. Significant pain can be experienced in [[myalgia|muscles]], muscle-tendon junctions, [[arthralgia|joints]], [[abdominal pain|abdomen]] or [[chest pain|chest]]. It is noninflammatory in nature and often migrates. e.g. generalized hyperalgesia, widespread pain (may meet fibromyalgia criteria), myofascial or radiating pain


====3. [[Sleep disturbance]]====
:a.[[Headache]]s: e.g. chronic, generalized headaches often involve aching of the eyes, behind the eyes or back of the head that may be associated with cervical muscle tension; [[migraine]]; [[tension-type headache|tension headaches]]
:b. Significant pain can be experienced in [[myalgia|muscles]], muscle-tendon junctions, [[arthralgia|joints]], [[abdominal pain|abdomen]] or [[chest pain|chest]]. It is noninflammatory in nature and often migrates. e.g. generalized [[hyperalgesia]], widespread pain (may meet [[fibromyalgia]] criteria), [[myofascial pain|myofascial]] or radiating pain


: a. Disturbed sleep patterns: e.g. [[insomnia]], prolonged sleep including naps, sleeping most of the day and being awake most of the night, frequent awakenings, awaking much earlier than before illness onset, vivid dreams/nightmares
<h4>3. [[Sleep disturbance]]</h4>
: b. Unrefreshed sleep: e.g. awaken feeling exhausted regardless of duration of sleep, day-time sleepiness


====4. Neurosensory, perceptual and motor disturbances====
: a. Disturbed sleep patterns: e.g. [[insomnia]], [[hypersomnia|prolonged sleep including naps]], [[sleep reversal|sleeping most of the day and being awake most of the night]], frequent awakenings, [[early waking|awaking much earlier]] than before illness onset, [[vivid dreams|vivid dreams/nightmares]]
: b. [[unrefreshing sleep|Unrefreshed sleep]]: e.g. awaken feeling exhausted regardless of duration of sleep, [[daytime sleepiness|day-time sleepiness]]


: a. Neurosensory and perceptual: e.g. inability to focus vision, [[photophobia|sensitivity to light]], noise, vibration, odour, taste and touch; impaired depth perception
<h4>4. Neurosensory, perceptual and motor disturbances</h4>
: b. Motor: e.g. muscle weakness, twitching, poor coordination, feeling unsteady on feet, [[ataxia]]


Notes: ''Neurocognitive impairments, reported or observed, become more pronounced with fatigue. Overload phenomena may be evident when two tasks are performed simultaneously. Abnormal accommodation responses of the pupils are common. Sleep disturbances are typically expressed by prolonged sleep, sometimes extreme, in the acute phase and often evolve into marked sleep reversal in the chronic stage.Motor disturbances may not be evident in mild or moderate cases but abnormal tandem gait and positive Romberg test may be observed in severe cases.''
: a. Neurosensory and perceptual: e.g. [[inability to focus vision]], [[photophobia|sensitivity to light]], [[Hyperacusis|noise]], vibration, odour, taste and touch; [[impaired depth perception]]
: b. Motor: e.g. [[paresis|muscle weakness]], [[fasciculation|twitching]], [[poor coordination]], feeling unsteady on feet, [[ataxia]]


===C. Immune, gastro-intestinal and genitourinary Impairments===
Notes: ''Neurocognitive impairments, reported or observed, become more pronounced with fatigue. [[Overload phenomena]] may be evident when [[multi-tasking problems|two tasks are performed simultaneously]]. Abnormal accommodation responses of the pupils are common. Sleep disturbances are typically expressed by prolonged sleep, sometimes extreme, in the acute phase and often evolve into marked [[sleep reversal]] in the chronic stage. Motor disturbances may not be evident in mild or moderate cases but [[abnormal tandem gait]] and [[Romberg test|positive Romberg test]] may be observed in severe cases.''
|-
| style="background-color: thistle;color:black;text-shadow:none;border: none" |
|<h3>Immune, gastro-intestinal and genitourinary impairments</h3>
|-
| style="background-color: thistle;color:black;text-shadow:none; " |C.
|
At least one symptom from three of the following five symptom categories
At least one symptom from three of the following five symptom categories


: 1. [[Flu-like illness|Flu-like symptoms]] may be recurrent or chronic and typically activate or worsen with exertion .e.g. [[sore throat]], [[sinusitis]], cervical and/or axillary lymph nodes may enlarge or be tender on palpitation
: 1. [[Flu-like illness|Flu-like symptoms]] may be recurrent or chronic and typically activate or [[Symptoms worsening with exertion|worsen with exertion]] e.g. [[sore throat]], [[sinusitis]], cervical and/or axillary [[swollen lymph nodes|lymph nodes may enlarge]] or be tender on palpitation
: 2. Susceptibility to [[virus|viral infections]] with prolonged recovery periods
: 2.[[Susceptibility to viruses|Susceptibility to viral infections]] with prolonged recovery periods
: 3. Gastro-intestinal tract: e.g. [[nausea]], [[abdominal pain]], [[bloating]], [[irritable bowel syndrome]]
: 3. Gastro-intestinal tract: e.g. [[nausea]], [[abdominal pain]], [[bloating]], [[irritable bowel syndrome]]
: 4. Genitourinary: e.g. urinary urgency or [[Urinary frequency|frequency]], nocturia
: 4. Genitourinary: e.g. urinary urgency or [[Urinary frequency|frequency]], [[nocturia]]
: 5. [[Development of new sensitivities|Sensitivities]] to [[Food sensitivities|food]], [[Medicine sensitivities|medications]], [[Odour sensitivities|odours]] or [[Chemical sensitivities|chemicals]]
: 5. [[new allergies or intolerances|Sensitivities]] to [[Food sensitivities|food]], [[Medicine sensitivities|medications]], [[Odor sensitivities|odours]] or [[multiple chemical sensitivity|chemicals]]


Notes: ''Sore throat, tender lymph nodes, and flu-like symptoms obviously are not specific to ME but their activation in reaction to exertion is abnormal. The throat may feel sore, dry and scratchy. Faucial injection and crimson crescents may be seen in the tonsillar fossae, which are an indication of immune activation.''
Notes: ''Sore throat, tender lymph nodes, and flu-like symptoms obviously are not specific to ME but their activation in reaction to exertion is abnormal. The throat may feel sore, dry and scratchy. Faucial injection and crimson crescents may be seen in the tonsillar fossae, which are an indication of immune activation.''
 
|-
===D. Energy production/transportation impairments: At least one symptom===
| style="background-color: lightsteelblue;color:black;text-shadow:none" |
 
|<h3>Energy production/transportation impairments: At least one symptom</h3>
: 1. Cardiovascular: e.g. inability to tolerate an upright position - [[orthostatic intolerance]], [[neurally mediated hypotension]], [[postural orthostatic tachycardia syndrome]], [[Heart palpitation|palpitations]] with or without cardiac arrhythmias, light-headedness/[[dizziness]]
|-
: 2. [[Respiratory]]: e.g. [[air hunger]], laboured breathing, fatigue of chest wall muscles
| style="background-color: lightsteelblue;color:black;text-shadow:none" |D.
: 3. Loss of [[thermostatic stability]]: e.g. subnormal body temperature, marked [[diurnal fluctuation]]s; [[excessive sweating|sweating episodes]], recurrent feelings of feverishness with or without low grade fever, cold extremities
|
: 1. Cardiovascular: e.g. inability to tolerate an upright position - [[orthostatic intolerance]], [[neurally mediated hypotension]], [[postural orthostatic tachycardia syndrome]], [[Heart palpitation|palpitations]] with or without [[arrhythmia|cardiac arrhythmias]], [[light-headedness]]/[[dizziness]]
: 2. [[Breathing problems in ME/CFS|Respiratory]]: e.g. [[air hunger]], [[laboured breathing]], [[fatigue of chest wall muscles]]
: 3.[[thermostatic instability|Loss of thermostatic stability]]: e.g. [[subnormal body temperature]], marked [[diurnal fluctuation]]s; [[excessive sweating|sweating episodes]], recurrent feelings of feverishness with or without [[low-grade fever|low grade fever]], [[cold hands and feet|cold extremities]]
: 4. [[Temperature sensitivity|Intolerance of extremes of temperature]]
: 4. [[Temperature sensitivity|Intolerance of extremes of temperature]]


Notes: ''[[Orthostatic intolerance]] may be delayed by several minutes. Patients who have orthostatic intolerance may exhibit mottling of extremities, extreme pallor or [[Raynaud's syndrome|Raynaud’s Phenomenon]]. In the chronic phase, moons of finger nails may recede.''
Notes: ''[[Orthostatic intolerance]] may be delayed by several minutes. Patients who have orthostatic intolerance may exhibit mottling of extremities, extreme pallor or [[Raynaud's syndrome|Raynaud's Phenomenon]]. In the chronic phase, moons of finger nails may recede.''
 
|-
===Paediatric considerations===
| colspan="2" |<h3>Paediatric considerations</h3>
|-
| colspan="2" |''Symptoms may progress more slowly in children than in teenagers or adults. In addition to [[postexertional neuroimmune exhaustion]], the most prominent symptoms tend to be neurological: [[headache]]s, [[cognitive impairment]]s, and [[sleep disturbance]]s.''


Symptoms may progress more slowly in children than in teenagers or adults. In addition to postexertional neuroimmune exhaustion, the most prominent symptoms tend to be neurological: [[headache]]s, [[cognitive impairment]]s, and [[sleep disturbance]]s.
:* '''[[Headache]]s:''' Severe or chronic headaches are often debilitating. [[Migraine]] may be accompanied by a rapid drop in temperature, shaking, [[vomiting]], [[diarrhoea]] and severe weakness.
:* '''Neurocognitive impairments:''' [[inability to focus vision|Difficulty focusing eyes]] and reading are common. Children may become [[dyslexia|dyslexic]], which may only be evident when fatigued. [[Slow processing of information]] makes it difficult to follow auditory instructions or take notes. All cognitive impairments [[Post-exertional symptom exacerbation|worsen with physical or mental exertion]]. Young people [[unable to go to school full-time|will not be able to maintain a full school program]].
:* '''[[Pain]]''' may seem erratic and migrate quickly. '''[[Hypermobility|Joint hypermobility]]''' is common.


: 1. [[Headache]]s: Severe or chronic headaches are often debilitating. [[Migraine]] may be accompanied by a rapid drop in temperature, shaking, [[vomiting]], [[diarrhoea]] and severe weakness.
'''''Notes:''''' ''Fluctuation and severity hierarchy of numerous prominent symptoms tend to vary more rapidly and dramatically.''
: 2. Neurocognitive impairments: Difficulty focusing eyes and reading are common. Children may become [[dyslexia|dyslexic]], which may only be evident when fatigued. Slow processing of information makes it difficult to follow auditory instructions or take notes. All cognitive impairments worsen with physical or mental exertion. Young people will not be able to maintain a full school program.
|-
: 3. [[Pain]] may seem erratic and migrate quickly. [[Hypermobility|Joint hypermobility]] is common.
| colspan="2" class="left" style="text-align: left" |<h3 class="center">Classification</h3>
 
Notes: ''Fluctuation and severity hierarchy of numerous prominent symptoms tend to vary more rapidly and dramatically than in adults.''
 
===Classification===


——— '''Myalgic encephalomyelitis'''
——— '''Myalgic encephalomyelitis'''


——— '''Atypical myalgic encephalomyelitis''': meets criteria for [[postexertional neuroimmune exhaustion]] but has a limit of two less than required of the remaining criterial symptoms. [[Pain]] or [[sleep disturbance]] may be absent in rare cases.
——— '''Atypical myalgic encephalomyelitis:'''<br />
 
meets criteria for [[postexertional neuroimmune exhaustion]] but has a limit of two less than required of the remaining criterial symptoms. [[Pain]] or [[sleep disturbance]] may be absent in rare cases.
'''Exclusions''': As in all diagnoses, exclusion of alternate explanatory diagnoses is achieved by the patient’s history, physical examination, and laboratory/biomarker testing as indicated. It is possible to have more than one disease but it is important that each one is identified and treated. Primary psychiatric disorders, [[somatoform disorder]] and [[substance abuse]] are excluded. Paediatric: [[‘primary’ school phobia]].
|-
 
| colspan="2" |<h3>Exclusions</h3>
'''Comorbid entities''': [[Fibromyalgia]], [[myofascial pain syndrome]], [[temporomandibular joint syndrome]], [[irritable bowel syndrome]], [[interstitial cystitis]], [[Raynaud's syndrome|Raynaud’s phenomenon]], [[prolapsed mitral valve]], [[migraines]], [[allergy|allergies]], [[multiple chemical sensitivities]], [[Hashimoto's thyroiditis]], [[Sicca syndrome]], [[Secondary depression|reactive depression]]. [[Migraine]] and [[irritable bowel syndrome]] may precede ME but then become associated with it. [[Fibromyalgia]] overlaps.
|-
| colspan="2" |As in all diagnoses, exclusion of alternate explanatory diagnoses is achieved by the patient’s history, physical examination, and laboratory/biomarker testing as indicated. It is possible to have more than one disease but it is important that each one is identified and treated. [[:Category:mental disorders|Primary psychiatric disorders]], [[somatoform disorder]] and [[substance abuse]] are excluded. Paediatric: [[school phobia|'primary' school phobia]].
|-
| colspan="2" |<h3>Comorbid entities</h3>
|-
| colspan="2" |[[Fibromyalgia]], [[myofascial pain syndrome]], [[temporomandibular joint syndrome]], [[irritable bowel syndrome]], [[interstitial cystitis]], [[Raynaud's syndrome|Raynaud’s phenomenon]], [[prolapsed mitral valve]], [[migraine]]s, [[allergy|allergies]], [[multiple chemical sensitivity|multiple chemical sensitivities]], [[Hashimoto's thyroiditis]], [[Sicca syndrome]], [[depression#Reactive_depression|reactive depression]]. [[Migraine]] and [[irritable bowel syndrome]] may precede ME but then become associated with it. [[Fibromyalgia]] overlaps.
|}


==Background and purpose==
==Background and purpose==
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Problem
Problem


Overly inclusive criteria have created misperceptions, fostered cynicism and have had a major negative impact on how ME is viewed by the medical community, patients, their families, as well as the general public. Some medical schools do not include ME in their curriculum with the result that very significant scientific advances and appropriate diagnostic and treatment protocols have not reached many busy medical practitioners. Some doctors may be unaware of the complexity and serious nature of ME. Patients may go undiagnosed and untreated; they may be shunned or isolated.<ref name="ICP2011primer">{{citation
Overly inclusive criteria have created misperceptions, fostered cynicism and have had a major negative impact on how ME is viewed by the medical community, patients, their families, as well as the general public. Some medical schools do not include ME in their curriculum with the result that very significant scientific advances and appropriate diagnostic and treatment protocols have not reached many busy medical practitioners. Some doctors may be unaware of the complexity and serious nature of ME. Patients may go undiagnosed and untreated; they may be shunned or isolated.<ref name="ICP2011primer">{{citation | last1 = Carruthers | first1 = BM | authorlink1 = Bruce Carruthers | last2 = van de Sande | first2 = MI | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = KL | authorlink3 = Kenny de Meirleir | last4 = Klimas | first4 = NG | authorlink4 = Nancy Klimas | last5 = Broderick | first5 = G | authorlink5 = Gordon Broderick | last6 = Mitchell | first6 = T | authorlink6 = Terry Mitchell | last7 = Staines | first7 = D | authorlink7 = Donald Staines | last8 = Powles | first8 = ACP | authorlink8 = A C Peter Powles | last9 = Speight | first9 = N | authorlink9 = Nigel Speight | last10 = Vallings | first10 = R | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = L | authorlink11 = Lucinda Bateman | last12 = Bell | first12 = DS | authorlink12 = David Bell | last13 = Carlo-Stella | first13 = N | authorlink13 = Nicoletta Carlo-Stella | last14 = Chia | first14 = J | authorlink14 = John Chia | last15 = Darragh | first15 = A | authorlink15 = Austin Darragh | last16 = Gerken | first16 = A | authorlink16 = Anne Gerken | last17 = Jo | first17 = D | authorlink17 = Daehyun Jo | last18 = Lewis | first18 = DP | authorlink18 = Donald Lewis | last19 = Light | first19 = AR | authorlink19 = Alan Light | last20 = Light | first20 = KC | authorlink20 = Kathleen Light | last21 = Marshall-Gradisnik | first21 = S | authorlink21 = Sonya Marshall-Gradisnik | last22 = McLaren-Howard | first22 = J | authorlink22 = John McLaren-Howard | last23 = Mena | first23 = I | authorlink23 = Ismael Mena | last24 = Miwa | first24 = K | authorlink24 = Kunihisa Miwa | last25 = Murovska | first25 = M | authorlink25= Modra Murovska | last26 = Stevens | first26 = SR | authorlink26 = Staci Stevens | title = Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners | date = 2012
| last1 = Carruthers | first1 = BM | authorlink1 = Bruce Carruthers
| isbn = 978-0-9739335-3-6 | url = http://www.investinme.org/Documents/Guidelines/Myalgic%20Encephalomyelitis%20International%20Consensus%20Primer%20-2012-11-26.pdf }}</ref>
| last2 = van de Sande | first2 = MI | authorlink2 = Marjorie van de Sande
| last3 = De Meirleir | first3 = KL | authorlink3 = Kenny de Meirleir
| last4 = Klimas | first4 = NG | authorlink4 = Nancy Klimas
| last5 = Broderick | first5 = G | authorlink5 = Gordon Broderick
| last6 = Mitchell | first6 = T | authorlink6 = Terry Mitchell
| last7 = Staines | first7 = D | authorlink7 = Donald Staines
| last8 = Powles | first8 = ACP | authorlink8 = A C Peter Powles
| last9 = Speight | first9 = N | authorlink9 = Nigel Speight
| last10 = Vallings | first10= R | authorlink10= Rosamund Vallings
| last11 = Bateman | first11= L | authorlink11= Lucinda Bateman
| last12 = Bell | first12= DS | authorlink12= David Bell
| last13 = Carlo-Stella | first13= N | authorlink13= Nicoletta Carlo-Stella
| last14 = Chia | first14= J | authorlink14= John Chia
| last15 = Darragh | first15= A | authorlink15= Austin Darragh
| last16 = Gerken | first16= A | authorlink16= Anne Gerken
| last17 = Jo | first17= D | authorlink17= Daehyun Jo
| last18 = Lewis | first18= DP | authorlink18= Donald Lewis
| last19 = Light | first19= AR | authorlink19= Alan Light
| last20 = Light | first20= KC | authorlink20= Kathleen Light
| last21 = Marshall-Gradisnik | first21= S | authorlink21= Sonya Marshall-Gradisnik
| last22 = McLaren-Howard | first22= J | authorlink22= John McLaren-Howard
| last23 = Mena | first23= I | authorlink23= Ismael Mena
| last24 = Miwa | first24= K | authorlink24= Kunihisa Miwa
| last25 = Murovska | first25= M | authorlink25= Modra Murovska
| last26 = Stevens | first26= SR | authorlink26= Staci Stevens
| title = Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners  
| date = 2012
| isbn = 978-0-9739335-3-6
| url = http://www.investinme.org/Documents/Guidelines/Myalgic%20Encephalomyelitis%20International%20Consensus%20Primer%20-2012-11-26.pdf
}}</ref>


==World Health Organisation==
==World Health Organisation==
Line 174: Line 166:
*Norwegian researchers compare the main criteria ([[Oxford criteria]], [[Fukuda criteria]], [[Canadian Consensus Criteria]], International Consensus Criteria and [[SEID]]). They say "it is important to distinguish between myalgic encephalomyelitis and chronic fatigue syndrome” to improve understanding of the disease, treatment and patients’ lives, as using incorrect criteria can lead to incorrect treatment.<ref name="Egeland2015" />
*Norwegian researchers compare the main criteria ([[Oxford criteria]], [[Fukuda criteria]], [[Canadian Consensus Criteria]], International Consensus Criteria and [[SEID]]). They say "it is important to distinguish between myalgic encephalomyelitis and chronic fatigue syndrome” to improve understanding of the disease, treatment and patients’ lives, as using incorrect criteria can lead to incorrect treatment.<ref name="Egeland2015" />


*'Scientists must agree on classifying patients’ Leonard Jason<ref>{{Cite journal|last=Jason|first=Leonard A.|last2=McManimen|first2=Stephanie|last3=Sunnquist|first3=Madison|last4=Brown|first4=Abigail|last5=Furst|first5=Jacob|last6=Newton|first6=Julia L.|last7=Strand|first7=Elin Bolle|date=2016-01-02|title=Case definitions integrating empiric and consensus perspectives|url=https://www.tandfonline.com/doi/abs/10.1080/21641846.2015.1124520?journalCode=rftg20|journal=Fatigue: Biomedicine, Health & Behavior|language=en|volume=4|issue=1|pages=1–23|doi=10.1080/21641846.2015.1124520|issn=2164-1846|pmc=4831204|pmid=27088059}}</ref>
*'Scientists must agree on classifying patients’ Leonard Jason<ref>{{Cite journal | last = Jason | first = Leonard A. | last2 = McManimen | first2 = Stephanie | last3 = Sunnquist | first3 = Madison | last4 = Brown | first4 = Abigail | last5 = Furst | first5 = Jacob | last6 = Newton | first6 = Julia L. | last7 = Strand | first7 = Elin Bolle | date = 2016-01-02 | title = Case definitions integrating empiric and consensus perspectives | url = https://www.tandfonline.com/doi/abs/10.1080/21641846.2015.1124520?journalCode=rftg20|journal = Fatigue: Biomedicine, Health & Behavior |language=en|volume=4|issue=1|pages=1–23|doi=10.1080/21641846.2015.1124520|issn=2164-1846|pmc=4831204|pmid=27088059}}</ref>
 
*Frank Twisk explains that ME and CFS are "distinct, partially overlapping, clinical entities such as ME and CFS" Frank Twisk 2016<ref>{{Cite journal | last = Twisk | first = Frank NM | date = 2015-06-26 | title = Accurate diagnosis of myalgic encephalomyelitis and chronic fatigue syndrome based upon objective test methods for characteristic symptoms | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482824/|journal=World Journal of Methodology|volume=5|issue=2 | pages = 68–87|doi=10.5662/wjm.v5.i2.68|issn=2222-0682|pmc=4482824|pmid=26140274}}</ref>
 
==Diagram of ME ICC symptoms ==
[[File:What-is-Myalgic-Encephalomyelitis-ME-ICC.png|550px|thumb|center|Simplified diagram of the main myalgic encephalomyelitis international consensus criteria symptoms]]
 
== Tool to determine if you meet ICC criteria ==
The following online questionnaire was developed by [[Schweizerische Gesellschaft für ME & CFS]], a patient association in Switzerland, to help you determine whether the diagnosis of ME (Myalgic Encephalomyelitis) according to the International Consensus Criteria (ICC) is applicable to you. English and Dutch versions are available.<ref>{{Cite web | url = https://sgme.ch/icc/en/ | title = Do I Have ME? | last = | first = | authorlink = | date = | website = |archive-url=|archive-date=|url-status=|access-date=Jan 10, 2022}}</ref>
 
[https://sgme.ch/icc/en/ Questionnaire in English]


*Frank Twisk explains that ME and CFS are "distinct, partially overlapping, clinical entities such as ME and CFS" Frank Twisk 2016<ref>{{Cite journal|last=Twisk|first=Frank NM|date=2015-06-26|title=Accurate diagnosis of myalgic encephalomyelitis and chronic fatigue syndrome based upon objective test methods for characteristic symptoms|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482824/|journal=World Journal of Methodology|volume=5|issue=2|pages=68–87|doi=10.5662/wjm.v5.i2.68|issn=2222-0682|pmc=4482824|pmid=26140274}}</ref>
[https://sgme.ch/icc/de/ Questionnaire in German]


==See also==
==See also==


*[[Definitions of ME and CFS]]
*[[Definitions of ME and CFS]]
*[[Canadian Consensus Criteria]]
*[[List_of_symptoms_in_ME_CFS|List of symptoms in ME/CFS]]
*[[List_of_symptoms_in_ME_CFS|List of symptoms in ME/CFS]]
*[[Common_symptoms_in_ME_CFS|Common symptoms]]
*[[Common_symptoms_in_ME_CFS|Common symptoms]]
Line 186: Line 189:


=== Generally accepted criteria for diagnosing ME and ME/CFS ===
=== Generally accepted criteria for diagnosing ME and ME/CFS ===
*[[Canadian Consensus Criteria]] (CCC)<ref name="Carruthers, 2003">{{Citation
*[[Canadian Consensus Criteria]] (CCC)<ref name="Carruthers, 2003">{{Citation | last =Carruthers | first1 = Bruce M. | authorlink1 = Bruce Carruthers | last2 = Jain | first2 = Anil Kumar | authorlink2 = Anil Kumar Jain | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Peterson | first4 = Daniel L. | authorlink4 = Daniel Peterson | last5 = Klimas | first5 = Nancy G. | authorlink5 = Nancy Klimas | last6 = Lerner | first6 = A. Martin | authorlink6 = Martin Lerner | last7 =Bested | first7 = Alison C. | authorlink7 = Alison Bested | last8 = Flor-Henry | first8 = Pierre | authorlink8 = Pierre Flor-Henry | last9 = Joshi | first9 = Pradip | authorlink9 = Pradip Joshi | last10 = Powles | first10 = AC Peter | authorlink10 = A C Peter Powles | last11 = Sherkey | first11 = Jeffrey A. | authorlink11 = Jeffrey Sherkey | last12 = van de Sande | first12 = Marjorie I. | authorlink12 = Marjorie van de Sande | title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols | journal = Journal of Chronic Fatigue Syndrome | volume = 11 | issue = 2 | pages = 7-115 | date = 2003 | pmid = | doi = 10.1300/J092v11n01_02 | url = http://phoenixrising.me/wp-content/uploads/Canadian-definition.pdf }}</ref>  A diagnosis of moderate and severe forms of [[ME/CFS]] are accurately made using this criterion. Adults can be diagnosed at 6 months while pediatric cases are diagnosed at three months.
| last1  = Carruthers   | first1 = Bruce M.     | authorlink1 = Bruce Carruthers  
*International Consensus Criteria (ICC)<ref name="icc" />  This criterion will accurately diagnose [[myalgic encephalomyelitis]] (ME). There is no requirement that the individual have symptoms for a specified period of time for diagnosis, as opposed to CCC, [[Fukuda criteria|Fukuda]], and [[Systemic Exertion Intolerance Disease|SEID]], which all require 6 months in adults.
| last2   = Jain         | first2 = Anil Kumar   | authorlink2 = Anil Kumar Jain
*[[Systemic Exertion Intolerance Disease]] (SEID)<ref>{{Cite web | url = http://iom.nationalacademies.org/~/media/Files/Report%20Files/2015/MECFS/MECFScliniciansguide.pdf | title=Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Redefining an Illness | last = Clayton | first = Ellen Wright | date = 2015 | website = National Academies|archive-url=|archive-date=|url-status=|access-date= | authorlink = Ellen Wright Clayton | last2 = Alegria | first2 = Margarita | authorlink2 = Margarita Alegria | authorlink3 = Lucinda Bateman | authorlink4 = Lily Chu | authorlink5 = Charles Cleeland | authorlink6 = Ronald Davis | authorlink7 = Betty Diamond | authorlink8 = Theodore Ganiats | author-link9 = Betsy Keller | last3 = Bateman | first3 = Lucinda | last4 = Chu | first4 = Lily | last5 = Cleeland | first5 = Charles | last6 = Davis | first6 = Ronald | last7 = Diamond | first7 = Betty | last8 = Ganiats | first8 = Theodore | last9 = Keller | first9 = Betsy | last10 = Klimas | first10 = Nancy | authorlink10=Nancy Klimas | last11 = Lerner | first11 = A Martin | authorlink11=Martin Lerner | last12 = Mulrow | first12 = Cynthia | authorlink12=Cynthia Mulrow | last13 = Natelson | first13 = Benjamin | authorlink13 = Benjamin Natelson | last14 = Rowe | first14 = Peter | authorlink14=Peter Rowe | last15 = Shelanski | first15 = Michael | authorlink15=Michael Shelanski}}</ref> ME/CFS ([[Systemic Exertion Intolerance Disease|SEID]]) is accurately diagnosed when the [[Systemic Exertion Intolerance Disease#Diagnostic criteria|core symptoms]] are met. The [[Institute of Medicine report]] as a whole is a comprehensive review of the medical literature available at time of publication (2015). Adults can be diagnosed at 6 months while pediatric cases are diagnosed at three months.
| last3   = De Meirleir   | first3 = Kenny L.     | authorlink3 = Kenny De Meirleir
| last4   = Peterson     | first4 = Daniel L.     | authorlink4 = Daniel Peterson
| last5   = Klimas       | first5 = Nancy G.     | authorlink5 = Nancy Klimas
| last6   = Lerner       | first6 = A. Martin     | authorlink6 = Martin Lerner
| last7   = Bested       | first7 = Alison C.     | authorlink7 = Alison Bested
| last8   = Flor-Henry   | first8 = Pierre       | authorlink8 = Pierre Flor-Henry  
| last9   = Joshi         | first9 = Pradip       | authorlink9 = Pradip Joshi
| last10 = Powles       | first10 = A C Peter   | authorlink10 = A C Peter Powles
| last11 = Sherkey       | first11 = Jeffrey A.   | authorlink11 = Jeffrey Sherkey
| last12 = van de Sande | first12 = Marjorie I. | authorlink12 = Marjorie van de Sande
| title   = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols
| journal = Journal of Chronic Fatigue Syndrome | volume = 11 | issue = 2 | page = 7-115
| date   = 2003
| pmid   =  
| doi     = 10.1300/J092v11n01_02
| url     = http://phoenixrising.me/wp-content/uploads/Canadian-definition.pdf
}}</ref>  A diagnosis of moderate and severe forms of [[ME/CFS]] are accurately made using this criterion. Adults can be diagnosed at 6 months while pediatric cases are diagnosed at three months.
*[[International Consensus Criteria]] (ICC)<ref name=":0" />  This criterion will accurately diagnose [[myalgic encephalomyelitis]] (ME). There is no requirement that the individual have symptoms for a specified period of time for diagnosis, as opposed to CCC, [[Fukuda criteria|Fukuda]], and [[Systemic Exertion Intolerance Disease|SEID]], which all require 6 months in adults.
*[[Systemic Exertion Intolerance Disease]] (SEID)<ref>{{Cite web|url=http://iom.nationalacademies.org/~/media/Files/Report%20Files/2015/MECFS/MECFScliniciansguide.pdf|title=Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Redefining an Illness|last=Clayton|first=Ellen Wright|date=2015|website=nationacademies.org|archive-url=|archive-date=|dead-url=|access-date=|authorlink=Ellen Wright Clayton|last2=Alegria|first2=Margarita|authorlink2=Margarita Alegria|authorlink3=Lucinda Bateman|authorlink4=Lily Chu|authorlink5=Charles Cleeland|authorlink6=Ronald Davis|authorlink7=Betty Diamond|authorlink8=Theodore Ganiats|authorlink9=Betsy Keller|authors=|last3=Bateman|first3=Lucinda|last4=Chu|first4=Lily|last5=Cleeland|first5=Charles|last6=Davis|first6=Ronald|last7=Diamond|first7=Betty|last8=Ganiats|first8=Theodore|last9=Keller|first9=Betsy|last10=Klimas|first10=Nancy|authorlink10=Nancy Klimas|last11=Lerner|first11=A Martin|authorlink11=Martin Lerner|last12=Mulrow|first12=Cynthia|authorlink12=Cynthia Mulrow|last13=Natelson|first13=Benjamin|authorlink13=Benjamin Natelson|last14=Rowe|first14=Peter|authorlink14=Peter Rowe|last15=Shelanski |first15=Michael|authorlink15=Michael Shelanski}}</ref> ME/CFS ([[Systemic Exertion Intolerance Disease|SEID]]) is accurately diagnosed when the [[Systemic Exertion Intolerance Disease#Diagnostic criteria|core symptoms]] are met. The [[Institute of Medicine report]] as a whole is a comprehensive review of the medical literature available at time of publication (2015). Adults can be diagnosed at 6 months while pediatric cases are diagnosed at three months.


==Learn more==
==Learn more==
Line 217: Line 201:
==References==
==References==
<references>
<references>
<ref name="Egeland2015">{{citation
<ref name="Egeland2015">{{citation | last =Egeland | first1 = T | authorlink1 = Torstein Egeland | last2 = Angelsen | first2 = A | authorlink2 = Arild Angelsen | last3 = Haug | first3 = R | authorlink3 = Ruth Haug | last4 = Henriksen | first4 = JO | authorlink4 = Jan-Olave Henriksen | last5 = Lea | first5 = TE | authorlink5 = Tor Erling Lea | last6 = Saugstad | first6 = OD | authorlink6 = Ola Didrik Saugstad | title = What exactly is myalgic encephalomyelitis?
| last1  = Egeland         | first1 = T                 | authorlink1 = Torstein Egeland
| type    = Perspectives | journal = Tidsskr Nor Legeforen | volume = 2015 | issue = 135 | page = 1756–9 | date =Oct 2015 | doi = 10.4045/tidsskr.15.0089 | url = http://tidsskriftet.no/article/3404849/en_GB
| last2   = Angelsen         | first2 = A                 | authorlink2 = Arild Angelsen
| lay-url = http://www.meaction.net/2015/12/10/norwegian-researchers-ask-what-exactly-is-m-e/ }}</ref>
| last3   = Haug             | first3 = R                 | authorlink3 = Ruth Haug
| last4   = Henriksen       | first4 = JO                 | authorlink4 = Jan-Olave Henriksen
| last5   = Lea             | first5 = TE                 | authorlink5 = Tor Erling Lea
| last6   = Saugstad         | first6 = OD                 | authorlink6 = Ola Didrik Saugstad
| title   = What exactly is myalgic encephalomyelitis?
| type    = Perspectives
| journal = Tidsskr Nor Legeforen | volume = 2015 | issue = 135 | page = 1756–9
| date   = Oct 2015
| doi     = 10.4045/tidsskr.15.0089  
| url     = http://tidsskriftet.no/article/3404849/en_GB
| lay-url = http://www.meaction.net/2015/12/10/norwegian-researchers-ask-what-exactly-is-m-e/
}}</ref>
</references>
</references>


[[Category:Definitions]]
[[Category:Definitions]]
[[Category:Secondary sources]]
[[Category:Secondary sources]]

Latest revision as of 17:25, April 2, 2023

Simplified ME International Consensus Criteria symptoms.

The Myalgic Encephalomyelitis (ME) International Consensus Criteria (ICC)[1] is a medical case definition that can accurately diagnose myalgic encephalomyelitis (ME), is a chronic, inflammatory, physically and neurologically disabling disease. For pediatric and adult cases a diagnosis should be made immediately; there is no need to wait up to 6 months.

Authors[edit | edit source]

Bruce Carruthers, Marjorie van de Sande, Kenny de Meirleir, Nancy Klimas, Gordon Broderick, Terry Mitchell, Donald Staines, A C Peter Powles, Nigel Speight, Rosamund Vallings, Lucinda Bateman, Barbara Baumgarten-Austrheim, David Bell, Nicoletta Carlo-Stella, John Chia, Austin Darragh, Daehyun Jo, Donald Lewis, Alan Light, Sonya Marshall-Gradisnik, Ismael Mena, Judy Mikovits, Kunihisa Miwa, Modra Murovska, Martin Pall, and Staci Stevens[1]

Criteria[edit | edit source]

A patient will meet the criteria for Myalgic Encephalomyelitis if they have:

A - Postexertional neuroimmune exhaustion

B - at least ONE neurological impairment symptom from THREE categories:

  1. Neurocognitive Impairments
  2. Pain          
  3. Sleep Disturbance      
  4. Neurosensory, Perceptual and Motor Disturbances

C - at least ONE immune/gastro-intestinal/genitourinary impairment from THREE categories:

  1. Flu-like symptoms may be recurrent or chronic and typically activate or worsen with exertion
  2. Susceptibility to viral infections with prolonged recovery periods
  3. Gastro-intestinal tract disturbances
  4. Genitourinary disturbances
  5. Sensitivities to food, medications, odors or chemicals, and

D - at least ONE energy metabolism/ion transport impairment symptom.

  1. Cardiovascular  
  2. Respiratory    
  3. Loss of thermostatic stability
  4. Intolerance of extremes of temperature  

Postexertional neuroimmune exhaustion (PENE pen’-e): Compulsory

A.

This cardinal feature is a pathological inability to produce sufficient energy on demand with prominent symptoms primarily in the neuroimmune regions. Characteristics are as follows:

1. Marked, rapid physical and/or cognitive fatigability in response to exertion, which may be minimal such as activities of daily living or simple mental tasks, can be debilitating and cause a relapse.
2. Postexertional symptom exacerbation: e.g. acute flu-like symptoms, pain and worsening of other symptoms.
3. Postexertional exhaustion may occur immediately after activity or be delayed by hours or days.
4. Recovery period is prolonged, usually taking 24h or longer. A relapse can last days, weeks or longer.
5. Low threshold of physical and mental fatigability (lack of stamina) results in a substantial reduction in pre-illness activity level.

Operational notes: For a diagnosis of ME, symptom severity must result in a significant reduction of a patient's premorbid activity level. Mild (an approximate 50% reduction in pre-illness activity level), moderate (mostly housebound), severe (mostly bedridden) or very severe (totally bedridden and need help with basic functions). There may be marked fluctuation of symptom severity and hierarchy from day to day or hour to hour. Consider activity, context and interactive effects. Recovery time: e.g. Regardless of a patient’s recovery time from reading for ½ hour, it will take much longer to recover from grocery shopping for ½ hour and even longer if repeated the next day – if able. Those who rest before an activity or have adjusted their activity level to their limited energy may have shorter recovery periods than those who do not pace their activities adequately. Impact: e.g. An outstanding athlete could have a 50% reduction in his/her pre-illness activity level and is still more active than a sedentary person.

Neurological impairments

B.

At least one symptom from three of the following four symptom categories

1. Neurocognitive impairments

a. Difficulty processing information: slowed thought, impaired concentration e.g. confusion, disorientation, cognitive overload, difficulty with making decisions, slowed speech, acquired or exertional dyslexia
b. Short-term memory loss: e.g. difficulty remembering what one wanted to say, what one was saying, retrieving words, recalling information, poor working memory

2. Pain

a. Headaches: e.g. chronic, generalized headaches often involve aching of the eyes, behind the eyes or back of the head that may be associated with cervical muscle tension; migraine; tension headaches
b. Significant pain can be experienced in muscles, muscle-tendon junctions, joints, abdomen or chest. It is noninflammatory in nature and often migrates. e.g. generalized hyperalgesia, widespread pain (may meet fibromyalgia criteria), myofascial or radiating pain

3. Sleep disturbance

a. Disturbed sleep patterns: e.g. insomnia, prolonged sleep including naps, sleeping most of the day and being awake most of the night, frequent awakenings, awaking much earlier than before illness onset, vivid dreams/nightmares
b. Unrefreshed sleep: e.g. awaken feeling exhausted regardless of duration of sleep, day-time sleepiness

4. Neurosensory, perceptual and motor disturbances

 a. Neurosensory and perceptual: e.g. inability to focus vision, sensitivity to light, noise, vibration, odour, taste and touch; impaired depth perception
 b. Motor: e.g. muscle weakness, twitching, poor coordination, feeling unsteady on feet, ataxia

Notes: Neurocognitive impairments, reported or observed, become more pronounced with fatigue. Overload phenomena may be evident when two tasks are performed simultaneously. Abnormal accommodation responses of the pupils are common. Sleep disturbances are typically expressed by prolonged sleep, sometimes extreme, in the acute phase and often evolve into marked sleep reversal in the chronic stage. Motor disturbances may not be evident in mild or moderate cases but abnormal tandem gait and positive Romberg test may be observed in severe cases.

Immune, gastro-intestinal and genitourinary impairments

C.

At least one symptom from three of the following five symptom categories

1. Flu-like symptoms may be recurrent or chronic and typically activate or worsen with exertion e.g. sore throat, sinusitis, cervical and/or axillary lymph nodes may enlarge or be tender on palpitation
2. Susceptibility to viral infections with prolonged recovery periods
3. Gastro-intestinal tract: e.g. nausea, abdominal pain, bloating, irritable bowel syndrome
4. Genitourinary: e.g. urinary urgency or frequency, nocturia
5. Sensitivities to food, medications, odours or chemicals

Notes: Sore throat, tender lymph nodes, and flu-like symptoms obviously are not specific to ME but their activation in reaction to exertion is abnormal. The throat may feel sore, dry and scratchy. Faucial injection and crimson crescents may be seen in the tonsillar fossae, which are an indication of immune activation.

Energy production/transportation impairments: At least one symptom

D.
1. Cardiovascular: e.g. inability to tolerate an upright position - orthostatic intolerance, neurally mediated hypotension, postural orthostatic tachycardia syndrome, palpitations with or without cardiac arrhythmias, light-headedness/dizziness
2. Respiratory: e.g. air hunger, laboured breathing, fatigue of chest wall muscles
3. Loss of thermostatic stability: e.g. subnormal body temperature, marked diurnal fluctuations; sweating episodes, recurrent feelings of feverishness with or without low grade fever, cold extremities
4. Intolerance of extremes of temperature

Notes: Orthostatic intolerance may be delayed by several minutes. Patients who have orthostatic intolerance may exhibit mottling of extremities, extreme pallor or Raynaud's Phenomenon. In the chronic phase, moons of finger nails may recede.

Paediatric considerations

Symptoms may progress more slowly in children than in teenagers or adults. In addition to postexertional neuroimmune exhaustion, the most prominent symptoms tend to be neurological: headaches, cognitive impairments, and sleep disturbances.

Notes: Fluctuation and severity hierarchy of numerous prominent symptoms tend to vary more rapidly and dramatically.

Classification

——— Myalgic encephalomyelitis

——— Atypical myalgic encephalomyelitis:
meets criteria for postexertional neuroimmune exhaustion but has a limit of two less than required of the remaining criterial symptoms. Pain or sleep disturbance may be absent in rare cases.

Exclusions

As in all diagnoses, exclusion of alternate explanatory diagnoses is achieved by the patient’s history, physical examination, and laboratory/biomarker testing as indicated. It is possible to have more than one disease but it is important that each one is identified and treated. Primary psychiatric disorders, somatoform disorder and substance abuse are excluded. Paediatric: 'primary' school phobia.

Comorbid entities

Fibromyalgia, myofascial pain syndrome, temporomandibular joint syndrome, irritable bowel syndrome, interstitial cystitis, Raynaud’s phenomenon, prolapsed mitral valve, migraines, allergies, multiple chemical sensitivities, Hashimoto's thyroiditis, Sicca syndrome, reactive depression. Migraine and irritable bowel syndrome may precede ME but then become associated with it. Fibromyalgia overlaps.

Background and purpose[edit | edit source]

The 2012 ICC is very clear on the topic of names:

Problem

The label ‘chronic fatigue syndrome’ (CFS), coined in the 1980s, has persisted due to lack of knowledge of its etiologic agents and pathophysiology. Misperceptions have arisen because the name ‘CFS’ and its hybrids ME/CFS, CFS/ME and CFS/CF have been used for widely diverse conditions. Patient sets can include those who are seriously ill with ME, many bedridden and unable to care for themselves, to those who have general fatigue or, under the Reeves criteria, patients are not required to have any physical symptoms. There is a poignant need to untangle the web of confusion caused by mixing diverse and often overly inclusive patient populations in one heterogeneous, multi-rubric pot called ‘chronic fatigue syndrome’. We believe this is the foremost cause of diluted and inconsistent research findings, which hinders progress, fosters scepticism, and wastes limited research monies.

Solution

The rationale for the development of the ICC was to utilize current research knowledge to identify objective, measurable and reproducible abnormalities that directly reflect the interactive, regulatory components of the underlying pathophysiology of ME. Specifically, the ICC select patients who exhibit explicit multi-systemic neuropathology, and have a pathological low threshold of physical and mental fatigability in response to exertion. Cardiopulmonary exercise test- retest studies have confirmed many post-exertional abnormalities. Criterial symptoms are compulsory and identify patients who have greater physical, cognitive and functional impairments. The ICC advance the successful strategy of the Canadian Consensus Criteria (CCC) of grouping coordinated patterns of symptom clusters that identify areas of pathology. The criteria are designed for both clinical and research settings.

1. Name: Myalgic encephalomyelitis, a name that originated in the 1950s, is the most accurate and appropriate name because it reflects the underlying multi-system pathophysiology of the disease. Our panel strongly recommends that only the name ‘myalgic encephalomyelitis’ be used to identify patients meeting the ICC because a distinctive disease entity should have one name. Patients diagnosed using broader or other criteria for CFS or its hybrids (Oxford, Reeves, London, Fukuda, CCC, etc.) should be reassessed with the ICC. Those who fulfill the criteria have ME; those who do not would remain in the more encompassing CFS classification. (bold emphasis mine)

2. Remove patients who satisfy the ICC from the broader category of CFS. The purpose of diagnosis is to provide clarity. The criterial symptoms, such as the distinctive abnormal responses to exertion can differentiate ME patients from those who are depressed or have other fatiguing conditions. Not only is it common sense to extricate ME patients from the assortment of conditions assembled under the CFS umbrella, it is compliant with the WHO classification rule that a disease cannot be classified under more than one rubric. The panel is not dismissing the broad components of fatiguing illnesses, but rather the ICC are a refinement of patient stratification. As other identifiable patient sets are identified and supported by research, they would then be removed from the broad CFS/CF category.

Research on ME: The logical way to advance science is to select a relatively homogeneous patient set that can be studied to identify biopathological mechanisms, biomarkers and disease process specific to that patient set, as well as comparing it to other patient sets. It is counterproductive to use inconsistent and overly inclusive criteria to glean insight into the pathophysiology of ME if up to 90% of the research patient sets may not meet its criteria (Jason 2009). Research on other fatiguing illnesses, such as cancer and multiple sclerosis (MS), is done on patients who have those diseases. There is a current, urgent need for ME research using patients who actually have ME. (bold emphasis mine)

4. Research confirmation: When research is applied to patients satisfying the ICC, previous findings based on broader criteria will be confirmed or refuted. Validation of ME being a differential diagnosis, as is multiple sclerosis (MS), or a subgroup of chronic fatigue syndrome, will then be verified.

5. Focus on treatment efficacy: With enhanced understanding of biopathological mechanisms, biomarkers and other components of pathophysiology specific to ME, more focus and research emphasis can target expanding and augmenting treatment efficacy.

International Consensus Primer (ICP)[edit | edit source]

Problem

Overly inclusive criteria have created misperceptions, fostered cynicism and have had a major negative impact on how ME is viewed by the medical community, patients, their families, as well as the general public. Some medical schools do not include ME in their curriculum with the result that very significant scientific advances and appropriate diagnostic and treatment protocols have not reached many busy medical practitioners. Some doctors may be unaware of the complexity and serious nature of ME. Patients may go undiagnosed and untreated; they may be shunned or isolated.[2]

World Health Organisation[edit | edit source]

The World Health Organisation (WHO) lists ME and post viral fatigue syndrome under neurological conditions. The diagnostic code is G93.3[3] Importantly, it doesn’t include chronic fatigue syndrome there, or ME/CFS or CFS/ME. Fatigue syndromes are listed in "Other neurotic disorders."[4]

Comparison with other criteria[edit | edit source]

M.E. and CFS are different but partially overlapping (Twisk, 2015)
  • Norwegian researchers compare the main criteria (Oxford criteria, Fukuda criteria, Canadian Consensus Criteria, International Consensus Criteria and SEID). They say "it is important to distinguish between myalgic encephalomyelitis and chronic fatigue syndrome” to improve understanding of the disease, treatment and patients’ lives, as using incorrect criteria can lead to incorrect treatment.[5]
  • 'Scientists must agree on classifying patients’ Leonard Jason[6]
  • Frank Twisk explains that ME and CFS are "distinct, partially overlapping, clinical entities such as ME and CFS" Frank Twisk 2016[7]

Diagram of ME ICC symptoms[edit | edit source]

Simplified diagram of the main myalgic encephalomyelitis international consensus criteria symptoms

Tool to determine if you meet ICC criteria[edit | edit source]

The following online questionnaire was developed by Schweizerische Gesellschaft für ME & CFS, a patient association in Switzerland, to help you determine whether the diagnosis of ME (Myalgic Encephalomyelitis) according to the International Consensus Criteria (ICC) is applicable to you. English and Dutch versions are available.[8]

Questionnaire in English

Questionnaire in German

See also[edit | edit source]

Generally accepted criteria for diagnosing ME and ME/CFS[edit | edit source]

  • Canadian Consensus Criteria (CCC)[9] A diagnosis of moderate and severe forms of ME/CFS are accurately made using this criterion. Adults can be diagnosed at 6 months while pediatric cases are diagnosed at three months.
  • International Consensus Criteria (ICC)[1] This criterion will accurately diagnose myalgic encephalomyelitis (ME). There is no requirement that the individual have symptoms for a specified period of time for diagnosis, as opposed to CCC, Fukuda, and SEID, which all require 6 months in adults.
  • Systemic Exertion Intolerance Disease (SEID)[10] ME/CFS (SEID) is accurately diagnosed when the core symptoms are met. The Institute of Medicine report as a whole is a comprehensive review of the medical literature available at time of publication (2015). Adults can be diagnosed at 6 months while pediatric cases are diagnosed at three months.

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 1.2 Carruthers, Bruce M.; van de Sande, Marjorie I.; De Meirleir, Kenny L.; Klimas, Nancy G.; Broderick, Gordon; Mitchell, Terry; Staines, Donald; Powles, A.C. Peter; Speight, Nigel; Vallings, Rosamund; Bateman, Lucinda; Baumgarten-Austrheim, Barbara; Bell, David; Carlo-Stella, Nicoletta; Chia, John; Darragh, Austin; Jo, Daehyun; Lewis, Donald; Light, Alan; Marshall-Gradisnik, Sonya; Mena, Ismael; Mikovits, Judy; Miwa, Kunihisa; Murovska, Modra; Pall, Martin; Stevens, Staci (August 22, 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327–338. doi:10.1111/j.1365-2796.2011.02428.x. ISSN 0954-6820. PMC 3427890. PMID 21777306.
  2. Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6
  3. WHO Classifications G93.3 - 2016
  4. WHO Classifications F48.0 - 2016
  5. Egeland, T; Angelsen, A; Haug, R; Henriksen, JO; Lea, TE; Saugstad, OD (October 2015), "What exactly is myalgic encephalomyelitis?", Tidsskr Nor Legeforen (Perspectives), 2015 (135): 1756–9, doi:10.4045/tidsskr.15.0089, lay summary
  6. Jason, Leonard A.; McManimen, Stephanie; Sunnquist, Madison; Brown, Abigail; Furst, Jacob; Newton, Julia L.; Strand, Elin Bolle (January 2, 2016). "Case definitions integrating empiric and consensus perspectives". Fatigue: Biomedicine, Health & Behavior. 4 (1): 1–23. doi:10.1080/21641846.2015.1124520. ISSN 2164-1846. PMC 4831204. PMID 27088059.
  7. Twisk, Frank NM (June 26, 2015). "Accurate diagnosis of myalgic encephalomyelitis and chronic fatigue syndrome based upon objective test methods for characteristic symptoms". World Journal of Methodology. 5 (2): 68–87. doi:10.5662/wjm.v5.i2.68. ISSN 2222-0682. PMC 4482824. PMID 26140274.
  8. "Do I Have ME?". Retrieved January 10, 2022.
  9. Carruthers, Bruce M.; Jain, Anil Kumar; De Meirleir, Kenny L.; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison C.; Flor-Henry, Pierre; Joshi, Pradip; Powles, AC Peter; Sherkey, Jeffrey A.; van de Sande, Marjorie I. (2003), "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols" (PDF), Journal of Chronic Fatigue Syndrome, 11 (2): 7–115, doi:10.1300/J092v11n01_02
  10. Clayton, Ellen Wright; Alegria, Margarita; Bateman, Lucinda; Chu, Lily; Cleeland, Charles; Davis, Ronald; Diamond, Betty; Ganiats, Theodore; Keller, Betsy; Klimas, Nancy; Lerner, A Martin; Mulrow, Cynthia; Natelson, Benjamin; Rowe, Peter; Shelanski, Michael (2015). "Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Redefining an Illness" (PDF). National Academies.