Interferon gamma inducible protein 10: Difference between revisions

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IP-10 is [[Interferon gamma|Interferon gamma (INF-γ) inducible protein]] 10, and is also known as '''C-X-C Motif Chemokine Ligand 10''' or '''CXCL10'''.<ref name="uniprot" /> IP-10 is a [[chemokine]], and important for recruiting [[Natural killer cell|natural killer cells]] to the myocardium, and for limiting viral duplication in murine (mice/rodent) [[coxsackievirus]] infection.<ref name="Loux2001">{{Cite book | last = Loux | first = Tara J. | last2 = Lotze | first2 = Michael T. | last3 = Zeh | first3 = Herbert J. | date = 2010-01-01|editor-last = Lotze|editor-first = Michael T.|editor2-last = Thomson|editor2-first = Angus W. | title = Chapter Fourteen - NK cells as recipients of cytokine signals|url=http://www.sciencedirect.com/science/article/pii/B9780123704542000144|location=San Diego|publisher=Academic Press|pages=189–201|isbn=9780123704542}}</ref>
IP-10 is [[Interferon gamma|Interferon gamma (INF-γ) inducible protein]] 10, and is also known as '''C-X-C Motif Chemokine Ligand 10''' or '''CXCL10'''.<ref name="uniprot" /> IP-10 is a [[chemokine]], and important for recruiting [[Natural killer cell|natural killer cells]] to the myocardium, and for limiting viral duplication in murine (mice/rodent) [[coxsackievirus]] infection.<ref name="Loux2001">{{Cite book | last = Loux | first = Tara J. | last2 = Lotze | first2 = Michael T. | last3 = Zeh | first3 = Herbert J. | date = 2010-01-01|editor-last = Lotze|editor-first = Michael T.|editor2-last = Thomson|editor2-first = Angus W. | title = Chapter Fourteen - NK cells as recipients of cytokine signals | url = http://www.sciencedirect.com/science/article/pii/B9780123704542000144|location=San Diego|publisher=Academic Press|pages=189–201|isbn=9780123704542}}</ref>


=== Alternative names ===
=== Alternative names ===
IP-10 is also known as:
IP-10 is also known as:
* CXCL10<ref name="uniprot">{{Cite web|url=https://www.uniprot.org/uniprot/P02778 | title = CXCL10 - C-X-C motif chemokine 10 precursor - Homo sapiens (Human) - CXCL10 gene & protein | website = uniprot.org|access-date=2019-01-24}}</ref>
* CXCL10<ref name="uniprot">{{Cite web | url = https://www.uniprot.org/uniprot/P02778 | title = CXCL10 - C-X-C motif chemokine 10 precursor - Homo sapiens (Human) - CXCL10 gene & protein | website = uniprot.org|access-date=2019-01-24}}</ref>
* C-X-C motif [[chemokine]] 10<ref name="uniprot" />
* C-X-C motif [[chemokine]] 10<ref name="uniprot" />
* [[Interferon gamma|IFN-γ]] inducible protein 10<ref name="Loux2001" />
* [[Interferon gamma|IFN-γ]] inducible protein 10<ref name="Loux2001" />
* [[Interferon gamma]] inducible protein 10
* [[Interferon gamma]] inducible protein 10
* 10 kDa interferon-gamma induced protein<ref>{{Cite book | date = 2013-01-01|editor-last = Lee|editor-first = James J.|editor2-last = Rosenberg|editor2-first = Helene F. | title = Chapter 6 - Eosinophil Trafficking | url =http://www.sciencedirect.com/science/article/pii/B9780123943859000067|location=Boston|publisher=Academic Press|pages=121–166|isbn=9780123943859 | last = | first = |journal=Eosinophils in Health and Disease|issue=|quote=|via=|volume=}}</ref>
* 10 kDa interferon-gamma induced protein<ref>{{Cite book | date = 2013-01-01|editor-last = Lee|editor-first = James J.|editor2-last = Rosenberg|editor2-first = Helene F. | title = Chapter 6 - Eosinophil Trafficking | url =http://www.sciencedirect.com/science/article/pii/B9780123943859000067|location=Boston|publisher=Academic Press|pages=121–166|isbn=9780123943859 | last = | first = |journal=Eosinophils in Health and Disease|issue=|quote=|via=|volume=}}</ref>


==Function==
==Function==
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==Notable studies ==
==Notable studies ==
* 2017 - The Role of [[IP-10]] in Chronic Fatigue Syndrome<ref>{{Cite journal | last = McArdle | first = Anne | author-link=Anne McArdle | last2 = Gusnanto | first2 = Arief | last3 = Earl | first3 = Kate | last4 = Sakellariou | first4 = George | last5 = Lawton | first5 = Clare | last6 = Owens | first6 = Daniel | last7 = Close | first7 = Graeme | last8 = Beadsworth | authorlink8 = Mike Beadsworth | first8 = Michael | last9 = Dye | first9 = Louise | date = 2017-04-01 | title = The role of IP-10 in Chronic Fatigue Syndrome.|url=https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.lb789|journal=The FASEB Journal|language=en|doi=10.1096/fasebj.31.1_supplement.lb789|issue=1 supplement|pages=lb789|volume=1|quote=|via=}}</ref>
* 2017 - The Role of [[IP-10]] in Chronic Fatigue Syndrome<ref>{{Cite journal | last = McArdle | first = Anne | authorlink = Anne McArdle | last2 = Gusnanto | first2 = Arief | last3 = Earl | first3 = Kate | last4 = Sakellariou | first4 = George | last5 = Lawton | first5 = Clare | last6 = Owens | first6 = Daniel | last7 = Close | first7 = Graeme | last8 = Beadsworth | authorlink8 = Mike Beadsworth | first8 = Michael | last9 = Dye | first9 = Louise | date = 2017-04-01 | title = The role of IP-10 in Chronic Fatigue Syndrome. | url = https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.lb789|journal=The FASEB Journal|language=en|doi=10.1096/fasebj.31.1_supplement.lb789|issue=1 supplement|pages=lb789|volume=1|quote=|via=}}</ref>


:''This study found "compelling evidence" of the role of several [[cytokine]]s/[[chemokine]]s in the physiological and cognitive pathology in a group of patients with [[chronic fatigue syndrome]], although these patients were selected using the [[Oxford criteria]], which includes many patients with [[chronic fatigue]] not caused by ME/CFS.''
:''This study found "compelling evidence" of the role of several [[cytokine]]s/[[chemokine]]s in the physiological and cognitive pathology in a group of patients with [[chronic fatigue syndrome]], although these patients were selected using the [[Oxford criteria]], which includes many patients with [[chronic fatigue]] not caused by ME/CFS.''

Latest revision as of 14:50, March 30, 2023

IP-10 is Interferon gamma (INF-γ) inducible protein 10, and is also known as C-X-C Motif Chemokine Ligand 10 or CXCL10.[1] IP-10 is a chemokine, and important for recruiting natural killer cells to the myocardium, and for limiting viral duplication in murine (mice/rodent) coxsackievirus infection.[2]

Alternative names[edit | edit source]

IP-10 is also known as:

Function[edit | edit source]

ME/CFS[edit | edit source]

Notable studies[edit | edit source]

  • 2017 - The Role of IP-10 in Chronic Fatigue Syndrome[4]
This study found "compelling evidence" of the role of several cytokines/chemokines in the physiological and cognitive pathology in a group of patients with chronic fatigue syndrome, although these patients were selected using the Oxford criteria, which includes many patients with chronic fatigue not caused by ME/CFS.

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 1.2 "CXCL10 - C-X-C motif chemokine 10 precursor - Homo sapiens (Human) - CXCL10 gene & protein". uniprot.org. Retrieved January 24, 2019.
  2. 2.0 2.1 Loux, Tara J.; Lotze, Michael T.; Zeh, Herbert J. (January 1, 2010). Lotze, Michael T.; Thomson, Angus W. (eds.). Chapter Fourteen - NK cells as recipients of cytokine signals. San Diego: Academic Press. pp. 189–201. ISBN 9780123704542.
  3. Lee, James J.; Rosenberg, Helene F., eds. (January 1, 2013). Chapter 6 - Eosinophil Trafficking. Eosinophils in Health and Disease. Boston: Academic Press. pp. 121–166. ISBN 9780123943859.
  4. McArdle, Anne; Gusnanto, Arief; Earl, Kate; Sakellariou, George; Lawton, Clare; Owens, Daniel; Close, Graeme; Beadsworth, Michael; Dye, Louise (April 1, 2017). "The role of IP-10 in Chronic Fatigue Syndrome". The FASEB Journal. 1 (1 supplement): lb789. doi:10.1096/fasebj.31.1_supplement.lb789.