Indoleamine-2,3-dioxygenase 2: Difference between revisions
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'''Indoleamine-2,3-dioxygenase 2''' is more commonly known as '''IDO2''' is an [[enzyme]] in the [[kynurenine pathway]] involved in the metabolism of the essential amino acid [[tryptophan]].<ref name="Ball2009">{{Cite journal|last=Ball|first=Helen J.|last2=Yuasa|first2=Hajime J.|last3=Austin|first3=Christopher J. D.|last4=Weiser|first4=Silvia|last5=Hunt|first5=Nicholas H.|date=2009-03-01|title=Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway|url=http://www.sciencedirect.com/science/article/pii/S1357272508000095|journal=The International Journal of Biochemistry & Cell Biology|volume=41|issue=3|pages=467–471|doi=10.1016/j.biocel.2008.01.005|issn=1357-2725}}</ref> The gene encoding IDO2 is also sometimes referred to as IDO2.{{ | '''Indoleamine-2,3-dioxygenase 2''' is more commonly known as '''IDO2''' is an [[enzyme]] in the [[kynurenine pathway]] involved in the metabolism of the essential amino acid [[tryptophan]].<ref name="Ball2009">{{Cite journal | last = Ball | first = Helen J. | last2 = Yuasa | first2 = Hajime J. | last3 = Austin | first3 = Christopher J.D. | last4 = Weiser | first4 = Silvia | last5 = Hunt | first5 = Nicholas H. | date = 2009-03-01 | title = Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway | url = http://www.sciencedirect.com/science/article/pii/S1357272508000095|journal=The International Journal of Biochemistry & Cell Biology|volume=41|issue=3 | pages = 467–471|doi=10.1016/j.biocel.2008.01.005|issn=1357-2725}}</ref> The gene encoding IDO2, also known as '''IDOL1''', is also sometimes referred to as IDO2.<ref>{{Cite web | url = https://www.ncbi.nlm.nih.gov/gene/169355 | title = IDO2 indoleamine 2,3-dioxygenase 2 [Homo sapiens (human)] - Gene - NCBI | last = National Center for Biotechnology Information | first = | authorlink = | date = Mar 13, 2020 | website = ncbi.nlm.nih.gov|archive-url=|archive-date=|url-status=|access-date=2020-05-01}}</ref> | ||
==Function== | ==Function== | ||
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== Notable studies and publications == | == Notable studies and publications == | ||
* 2019, The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS<ref name="Phair2019">{{Cite journal|last=Phair|first= | * 2019, The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS<ref name="Phair2019">{{Cite journal | last = Phair | first = RobertD. | authorlink = Robert Phair | last2 = Davis | first2 = Ronald W. | authorlink2 = Ron Davis | last3 = Kashi | first3 = Alex A. | authorlink3 = Alex Kashi | authorlink4 = | authorlink5 = | authorlink6 = | date = 2019 | title=The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS | url = https://www.mdpi.com/2075-4418/9/3/82|journal=Diagnostics|language=en|volume=9|issue=3 | pages = 82|doi=10.3390/diagnostics9030082|quote=|via=}}</ref> [https://www.mdpi.com/2075-4418/9/3/82/htm (Full text)] | ||
==See also== | ==See also== | ||
*[[Indoleamine-2,3-dioxygenase 1]] (IDO1) | |||
* [[Metabolic trap]] | * [[Metabolic trap]] | ||
* [[Kynurenine pathway]] | * [[Kynurenine pathway]] | ||
* [[ | * [[Tryptophan]] | ||
* [[ | * [[Kynurenine]] | ||
==Learn more== | ==Learn more== | ||
* [https://www.ncbi.nlm.nih.gov/gene/169355 IDO2] - National Center for Biotechnology Information | |||
==References== | ==References== | ||
Latest revision as of 10:43, April 2, 2023
 | This article is a stub. |
Indoleamine-2,3-dioxygenase 2 is more commonly known as IDO2 is an enzyme in the kynurenine pathway involved in the metabolism of the essential amino acid tryptophan.[1] The gene encoding IDO2, also known as IDOL1, is also sometimes referred to as IDO2.[2]
Function[edit | edit source]
ME/CFS[edit | edit source]
The ME/CFS Severely Ill Big Data Project analyzed genes of 20 patients who were severely ill with ME and CFS, and identified several different genetic defects in the genes encoding the IDO2 enzyme.
Notable studies and publications[edit | edit source]
- 2019, The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS[3] (Full text)
See also[edit | edit source]
Learn more[edit | edit source]
- IDO2 - National Center for Biotechnology Information
References[edit | edit source]
- ↑ Ball, Helen J.; Yuasa, Hajime J.; Austin, Christopher J.D.; Weiser, Silvia; Hunt, Nicholas H. (March 1, 2009). "Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway". The International Journal of Biochemistry & Cell Biology. 41 (3): 467–471. doi:10.1016/j.biocel.2008.01.005. ISSN 1357-2725.
- ↑ National Center for Biotechnology Information (March 13, 2020). "IDO2 indoleamine 2,3-dioxygenase 2 [Homo sapiens (human)] - Gene - NCBI". ncbi.nlm.nih.gov. Retrieved May 1, 2020.
- ↑ Phair, RobertD.; Davis, Ronald W.; Kashi, Alex A. (2019). "The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS". Diagnostics. 9 (3): 82. doi:10.3390/diagnostics9030082.
