Immunoadsorption: Difference between revisions
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'''Immunoadsorption''' is the technique by which pathogenic substances, especially undesirable antibodies, are removed from blood [[plasma]]. Immunoadsorption is considered to have fewer adverse effects than the use of therapeutic plasma exchange.<ref name="Pham, 2013">{{Citation | '''Immunoadsorption''' is the technique by which pathogenic substances, especially undesirable antibodies, are removed from blood [[plasma]]. Immunoadsorption is considered to have fewer adverse effects than the use of therapeutic plasma exchange.<ref name="Pham, 2013">{{Citation | ||
| last1 = Pham | first1 = | | last1 = Pham | first1 = H. P. | authorlink1 = | ||
| last2 = Schwartz | first2 = | | last2 = Schwartz | first2 = J. | authorlink2 = | ||
| title = | | title = Transfusion medicine and hemostasis: clinical and laboratory aspects. | ||
| journal = | | journal = | page = | date = 2013 | ||
| pmid = | doi = 10.1016/B978-0-12-397164-7.00079-3}} | | pmid = | doi = 10.1016/B978-0-12-397164-7.00079-3|url=|pages=525–527|chapter=79 - Immunoadsorption|edition=2|isbn=|place=Newnes|editor-last=Shaz|editor-first=B. H.|editor2-last=Hillyer|editor2-first=C.D.}} | ||
</ref> Several medical conditions, such as [[multiple sclerosis]]<ref name="Koziolek2018"> | </ref> Several medical conditions, such as [[multiple sclerosis]]<ref name="Koziolek2018">{{Cite journal|last=Koziolek|first=Michael J.|last2=Tampe|first2=Desiree|last3=Bähr|first3=Matthias|last4=Dihazi|first4=Hassan|last5=Jung|first5=Klaus|last6=Fitzner|first6=Dirk|last7=Klingel|first7=Reinhard|last8=Müller|first8=Gerhard A.|last9=Kitze|first9=Bernd|date=2012-04-26|title=Immunoadsorption therapy in patients with multiple sclerosis with steroid-refractory optical neuritis|url=https://doi.org/10.1186/1742-2094-9-80|journal=Journal of Neuroinflammation|volume=9|issue=1|pages=80|doi=10.1186/1742-2094-9-80|issn=1742-2094|pmc=PMC3418188|pmid=22537481}}</ref> and chronic inflammatory demyelinating polyneuropathy (CIDP)<ref name="Lehmann2013">{{Cite journal|last=Lehmann|first=Helmar C.|author-link=|last2=Hughes|first2=Richard A. C.|author-link2=|last3=Hartung|first3=Hans-Peter|author-link3=|last4=|first4=|author-link4=|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=2013-01-01|editor-last=Said|editor-first=Gérard|editor2-last=Krarup|editor2-first=Christian|title=Handbook of Clinical Neurology,|url=https://www.sciencedirect.com/science/article/pii/B9780444529022000230|journal=|chapter=23 - Treatment of chronic inflammatory demyelinating polyradiculoneuropathy|series=Peripheral Nerve Disorders|language=en|publisher=Elsevier|volume=115|issue=|pages=415–427|doi=10.1016/b978-0-444-52902-2.00023-0|pmc=|pmid=|access-date=|quote=|via=}}</ref> may use immunoadsorption as part of their medical regimen. | ||
==Theory== | ==Theory== | ||
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==Evidence== | ==Evidence== | ||
*2018, Immunoadsorption to remove ß2 adrenergic receptor antibodies in Chronic Fatigue Syndrome CFS/ME<ref name="Scheibenbogen2018">Scheibenbogen | *2018, Immunoadsorption to remove ß2 adrenergic receptor antibodies in Chronic Fatigue Syndrome CFS/ME<ref name="Scheibenbogen2018">{{Cite journal|last=Scheibenbogen|first=Carmen|author-link=Carmen Scheibenbogen|last2=Loebel|first2=Madlen|author-link2=Madlen Löbel|last3=Freitag|first3=Helma|author-link3=Helma Freitag|last4=Krueger|first4=Anne|author-link4=|last5=Bauer|first5=Sandra|author-link5=Sandra Bauer|last6=Antelmann|first6=Michaela|author-link6=|last7=Doehner|first7=Wolfram|last8=Scherbakov|first8=Nadja|last9=Heidecke|first9=Harald|date=2018-03-15|title=Immunoadsorption to remove ß2 adrenergic receptor antibodies in Chronic Fatigue Syndrome CFS/ME|url=https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193672|journal=PLOS ONE|language=en|volume=13|issue=3|pages=e0193672|doi=10.1371/journal.pone.0193672|issn=1932-6203|pmc=PMC5854315|pmid=29543914|access-date=|quote=|via=}}</ref> [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193672 (Full Text)] | ||
==Clinicians== | ==Clinicians== | ||
Revision as of 17:18, September 28, 2021
Immunoadsorption is the technique by which pathogenic substances, especially undesirable antibodies, are removed from blood plasma. Immunoadsorption is considered to have fewer adverse effects than the use of therapeutic plasma exchange.[1] Several medical conditions, such as multiple sclerosis[2] and chronic inflammatory demyelinating polyneuropathy (CIDP)[3] may use immunoadsorption as part of their medical regimen.
Theory[edit | edit source]
A number of studies have found that a subset of ME/CFS patients have abnormal autoantibodies in their blood; immunoadsorption could be used to remove these autoantibodies with the aim of improving symptoms or potentially curing ME/CFS in those patients.[4]
Evidence[edit | edit source]
- 2018, Immunoadsorption to remove ß2 adrenergic receptor antibodies in Chronic Fatigue Syndrome CFS/ME[4] (Full Text)
Clinicians[edit | edit source]
Risks and safety[edit | edit source]
Costs and availability[edit | edit source]
Learn more[edit | edit source]
- Wikipedia page for Immunoadsorption
- 2018, Hope for an ME/CFS Autoimmune Subset: A German Researcher Steps Forward (Carmen Scheibenbogen)
See also[edit | edit source]
References[edit | edit source]
- ↑ Pham, H. P.; Schwartz, J. (2013), "79 - Immunoadsorption", in Shaz, B. H.; Hillyer, C.D. (eds.), Transfusion medicine and hemostasis: clinical and laboratory aspects. (2 ed.), Newnes, pp. 525–527, doi:10.1016/B978-0-12-397164-7.00079-3
- ↑ Koziolek, Michael J.; Tampe, Desiree; Bähr, Matthias; Dihazi, Hassan; Jung, Klaus; Fitzner, Dirk; Klingel, Reinhard; Müller, Gerhard A.; Kitze, Bernd (April 26, 2012). "Immunoadsorption therapy in patients with multiple sclerosis with steroid-refractory optical neuritis". Journal of Neuroinflammation. 9 (1): 80. doi:10.1186/1742-2094-9-80. ISSN 1742-2094. PMC 3418188. PMID 22537481.
- ↑ Lehmann, Helmar C.; Hughes, Richard A. C.; Hartung, Hans-Peter (January 1, 2013). Said, Gérard; Krarup, Christian (eds.). "Handbook of Clinical Neurology,". Peripheral Nerve Disorders. 115. Elsevier: 415–427. doi:10.1016/b978-0-444-52902-2.00023-0. Cite journal requires
|journal=(help);|chapter=ignored (help) - ↑ 4.0 4.1 Scheibenbogen, Carmen; Loebel, Madlen; Freitag, Helma; Krueger, Anne; Bauer, Sandra; Antelmann, Michaela; Doehner, Wolfram; Scherbakov, Nadja; Heidecke, Harald (March 15, 2018). "Immunoadsorption to remove ß2 adrenergic receptor antibodies in Chronic Fatigue Syndrome CFS/ME". PLOS ONE. 13 (3): e0193672. doi:10.1371/journal.pone.0193672. ISSN 1932-6203. PMC 5854315. PMID 29543914.
