Immune system
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
The immune system is primarily formed by the innate immune system which we are born with, and the adaptive immune system which learns how to fight pathogens (for example from vaccines, or infections we contract).
Innate immune system[edit | edit source]
Barriers[edit | edit source]
Inflammation[edit | edit source]
Complement[edit | edit source]
Leukocytes[edit | edit source]
Natural killer cells[edit | edit source]
Adaptive immune system[edit | edit source]
Lymphocytes[edit | edit source]
Immunological memory[edit | edit source]
Immunodeficiency[edit | edit source]
Autoimmunity[edit | edit source]
ME/CFS patients have anti-cholinergic muscarinic, Β-adrenergic[1], phosphatidylinositol[2] and serotonin[3] antibodies when compared to healthy controls.
Hypersensitivity[edit | edit source]
Chronic fatigue syndrome[edit | edit source]
There is evidence of immune dysregulation in chronic fatigue syndrome.
Reduced natural killer cell function.[4]
Elevated regulatory T cells[5]
Learn more[edit | edit source]
- Crash Course - The Immune System Part 1 (Adaptive immune system)
- Crash Course - The Immune System Part 2 (humoral immunity & B cells)
- Crash Course - The Immune System Part 3 (cell-mediated immunity & T cells)
See also[edit | edit source]
References[edit | edit source]
- ↑ Loebel, Madlen; Grabowski, Patricia; Heidecke, Harald; Bauer, Sandra; Hanitsch, Leif G.; Wittke, Kirsten; Meisel, Christian; Reinke, Petra; Volk, Hans-Dieter (February 2016). "Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome". Brain, Behavior, and Immunity. 52: 32–39. doi:10.1016/j.bbi.2015.09.013. ISSN 1090-2139. PMID 26399744.
- ↑ Maes, Michael; Mihaylova, Ivanka; Leunis, Jean-Claude (December 2007). "Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression". Neuro Endocrinology Letters. 28 (6): 861–867. ISSN 0172-780X. PMID 18063934.
- ↑ Maes, Michael; Ringel, Karl; Kubera, Marta; Anderson, George; Morris, Gerwyn; Galecki, Piotr; Geffard, Michel (September 5, 2013). "In myalgic encephalomyelitis/chronic fatigue syndrome, increased autoimmune activity against 5-HT is associated with immuno-inflammatory pathways and bacterial translocation". Journal of Affective Disorders. 150 (2): 223–230. doi:10.1016/j.jad.2013.03.029. ISSN 1573-2517. PMID 23664637.
- ↑ Brenu, Ekua Weba; Huth, Teilah K.; Hardcastle, Sharni L.; Fuller, Kirsty; Kaur, Manprit; Johnston, Samantha; Ramos, Sandra B.; Staines, Don R.; Marshall-Gradisnik, Sonya M. (April 2014). "Role of adaptive and innate immune cells in chronic fatigue syndrome/myalgic encephalomyelitis". International Immunology. 26 (4): 233–242. doi:10.1093/intimm/dxt068. ISSN 1460-2377. PMID 24343819.
- ↑ Brenu, Ekua Weba; Huth, Teilah K.; Hardcastle, Sharni L.; Fuller, Kirsty; Kaur, Manprit; Johnston, Samantha; Ramos, Sandra B.; Staines, Don R.; Marshall-Gradisnik, Sonya M. (April 2014). "Role of adaptive and innate immune cells in chronic fatigue syndrome/myalgic encephalomyelitis". International Immunology. 26 (4): 233–242. doi:10.1093/intimm/dxt068. ISSN 1460-2377. PMID 24343819.
