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Idiopathic chronic fatigue
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[[File:Chronic-Fatigue-Patil.jpg|3206px|right|thumb|Source: Chronic fatigue syndrome: A review (Balachander et al.) 2014.<ref name="Singh2014">{{Cite journal | last = Singh | first = Shubh Mohan | last2 = Sarkar | first2 = Siddharth | last3 = Rao | first3 = Pradyumna | last4 = Balachander | first4 = Srinivas| date = 2014-07-01| title = Chronic fatigue syndrome: A review | url =http://www.mjdrdypu.org/article.asp?issn=0975-2870;year=2014;volume=7;issue=4;spage=415;epage=422;aulast=Balachander | journal = Medical Journal of Dr.D.Y. Patil University|language=en|volume=7|issue=4 | pages = 415|doi=10.4103/0975-2870.135252|issn=0975-2870|quote=|via=}}</ref>. License: CC BY-NC-4.0]] '''Idiopathic chronic fatigue''' (ICF) or'''chronic idiopathic fatigue" (CIF) is long lasting [[chronic fatigue]] that is not caused by an underlying medical condition or psychiatric illness and does not meet the criteria for [[chronic fatigue syndrome]].<ref name="fukuda1994"/><ref name="Valiani2019" /> Patients with idiopathic chronic fatigue have different diagnostic criteria to patients with [[chronic fatigue syndrome]] (CFS).<ref name="fukuda1994"/><ref name="Son2019" /> The word ''idiopathic'' reflects an unknown underlying cause, meaning that the chronic fatigue is a [[Medically unexplained symptoms|medically unexplained symptom]].<ref name="Valiani2019" /><ref name=":0">{{Cite web | url = https://www.docsopinion.com/2017/11/08/causes-fatigue-tiredness-chronic-fatigue/| title = 19 Important Causes of Fatigue - Tiredness and Chronic Fatigue Explained | last = Sigurdsson MD | first = Alex F. | authorlink = | date = Nov 8, 2017 | website = docsopinion.com|archive-url=|archive-date = |url-status=|access-date = 2019-01-30}}</ref> ==Differences from chronic fatigue syndrome== [[File:ChronicFatigueSyndrome-IdiopathicChronicFatigue-Differences.jpg|left|thumb|Chronic Fatigue Syndrome (CFS) is a distinct neurological disease, and is not the same as chronic fatigue, or long-term fatigue with no known cause (ICF).<ref name="Son2019" /> ''Source: Son, C-G (2019). Differential diagnosis between “chronic fatigue” and “chronic fatigue syndrome”. Integrative Medicine Research, 8(2), 89-91. Suggested algorithm for chronic fatigue, ICF and CFS. License: CC-BY-ND-NC.'']] {{clear}} <div style="column-count:2;webkit-column-count:2;-moz-column-count: 2;" class="hlist"> *Idiopathic chronic fatigue is a distinct illness but not classed as either a syndrome or disease. *Idiopathic chronic fatigue only requires the symptom of [[chronic fatigue|chronic fatigue.]] which is not explained by another medical condition, and does not meet the CFS criteria.<ref name="fukuda1994"/><ref name="Son2019" /> *Idiopathic chronic fatigue does not require either [[post-exertional malaise]] or [[sleep dysfunction]], which are both compulsory symptoms for a CFS diagnosis. *Idiopathic chronic fatigue is more common in the elderly and becomes more common with ageing.<ref name="Valiani2019" /> *Idiopathic chronic fatigue is a classed as a general diagnosis rather than neurological or musculoskeletal, and uses ICD-11 code MG22,<ref name="ICD-11">https://icd.who.int/browse11/l-m/en#/http%3a%2f%2fid.who.int%2ficd%2fentity%2f1829103493</ref> and ICD-10-CM code R53.8.<ref name="ICD-10-CM">{{cite web |url=https://icd10cmtool.cdc.gov/?fy=FY2022&query=fatigue |website=National Center for Health Statistics|title=R53 Malaise and fatigue {{!}} General symptoms and signs (R50-R69) {{!}} ICD-10-CM Index and Tabular|date=2007|access-date=2022-09-21}}</ref><ref name="ICD10-CM">https://www.cdc.gov/me-cfs/healthcare-providers/diagnosis/icd-10.html</ref> *Chronic fatigue syndrome is a [[neurological disorder|neurological disease]], and the ICD-11 code 8E49<ref name="ICD11-CFS">{{Cite web|url=https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/569175314|title=8E49 Postviral fatigue syndrome |last=World Health Organization|first=|authorlink=World Health Organization|date=|website=ICD-11 - Mortality and Morbidity Statistics|language=en|archive-url=|archive-date=|access-date=2022-03-19|quote='''8E49 Postviral fatigue syndrome'''<br />Other disorders of the nervous system<br />Inclusions<br />chronic fatigue syndrome<br/>myalgic encephalomyelitis<br />Exclusions<br/>Fatigue (MG22)}}</ref> and ICD-10-CM code G93.32 both reflect this.<ref name="ICD-10-CM"></ref> *[[Chronic fatigue syndrome]] is a multi-systemic illness with a wide variety of symptoms, which may include: immune symptoms, cardiovascular symptoms, [[post-exertional malaise]], [[headache]]s or [[migraine]]s, and [[chronic pain]].<ref name="Son2019" /><ref name="fukuda1994">{{Cite journal | last = Fukuda | first = K. | authorlink = Keiji Fukuda | last2 = Straus | first2 = S.E. | author-link2 = Stephen Straus | last3 = Hickie | first3 = I. | author-link3 = Ian Hickie | last4 = Sharpe | first4 = M.C. | author-link4 = Michael Sharpe | last5 = Dobbins | first5 = J.G. | authorlink5 = James Dobbins | last6 = Komaroff | first6 = A. | author-link6 = Anthony Komaroff | date = 1994-12-15| title = The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group | url =https://www.researchgate.net/profile/Michael_Sharpe2/publication/247808895_The_Chronic_Fatigue_Syndrome_A_Comprehensive_Approach_to_Its_Definition_and_Study/links/0c96053201643bfc4b000000/The-Chronic-Fatigue-Syndrome-A-Comprehensive-Approach-to-Its-Definition-and-Study.pdf | journal=Annals of Internal Medicine|volume=121|issue=12 | pages = 953–959|issn=0003-4819|pmid=7978722|via=|publisher=American College of Physicians}}</ref> *Chronic fatigue syndrome is most common in teenagers and working age adults. *Idiopathic chronic fatigue is generally considered less disabling.<ref name="Valiani2019" /> </div> == Notable studies == *1992, Chronic tiredness and idiopathic chronic fatigue--a connection?<ref name="Simpson1992">{{Cite journal | url = https://pubmed.ncbi.nlm.nih.gov/1574202/| title = Chronic Tiredness and Idiopathic Chronic Fatigue--A Connection? | last = Simpson | first = LO | authorlink=| date = Mar 1992 | journal = New Jersey medicine | pages = 211‐216|language=en|pmid=1574202|archive-url=|archive-date = |url-status=|access-date = 2020-05-22|volume=89|issue=3}}</ref> - [https://www.ncbi.nlm.nih.gov/pubmed/1574202 (Abstract)] * 1999, Idiopathic chronic fatigue and chronic fatigue syndrome: a comparison of two case-definitions<ref name="carrieri1999">{{Cite web | url = https://pubmed.ncbi.nlm.nih.gov/10721210/| title = Idiopathic Chronic Fatigue and Chronic Fatigue Syndrome: A Comparison of Two Case-Definitions | last = C | first = Arpino | last2 = Mp | first2 = Carrieri | date = 1999 | website = Annali dell'Istituto superiore di sanita|language=en|pmid=10721210|access-date = 2020-05-22 | last3 = G | first3 = Valesini | last4 = E | first4 = Pizzigallo | last5 = P | first5 = Rovere | last6 = U | first6 = Tirelli | last7 = F | first7 = Conti | last8 = P | first8 = Dialmi | last9 = A | first9 = Barberio}}</ref> - [https://europepmc.org/article/med/10721210 (Abstract)] *2004, Disability in chronic fatigue syndrome and idiopathic chronic fatigue<ref name="carrico2004">{{Cite journal | last = Carrico | first = Adam W. | last2 = Jason | first2 = Leonard A. | last3 = Witter | first3 = Elizabeth | last4 = Torres-Harding | first4 = Susan | date = 2004| title = Disability in Chronic Fatigue Syndrome and Idiopathic Chronic Fatigue | url = https://rdsjournal.org/index.php/journal/article/view/14 | journal = Review of Disability Studies: An International Journal|language=en|volume=1|issue=1|issn=1552-9215}}</ref> - [http://128.171.57.22/bitstream/10125/58528/46.pdf (Full text)] *2007/updated 2009, Traditional Chinese medicinal herbs for idiopathic chronic fatigue and chronic fatigue syndrome<ref>{{Cite journal | last = Adams | first = Denise | last2 = Wu | first2 = Taixiang | last3 = Tai | first3 = Shusheng | last4 = Wiebe | first4 = Natasha | last5 = Vohra | first5 = Sunita | date = 2007 | title=Traditional Chinese medicinal herbs for idiopathic chronic fatigue and chronic fatigue syndrome | url = https://www.cochranelibrary.com/content?templateType=full&urlTitle=%2Fcdsr%2Fdoi%2F10.1002%2F14651858.CD006348&doi=10.1002%2F14651858.CD006348&type=cdsr&contentLanguage= | journal = Cochrane Database of Systematic Reviews|language=en|issue=1|doi=10.1002/14651858.CD006348|issn=1465-1858}}</ref> - [https://www.cochranelibrary.com/content?templateType=full&urlTitle=/cdsr/doi/10.1002/14651858.CD006348&doi=10.1002/14651858.CD006348&type=cdsr&contentLanguage= (Full text)] *2012, Fatigue severity of patients with idiopathic chronic fatigue compared to healthy subjects<ref name="Lee2012">{{Cite journal | last = Lee | first = Nam Hun | last2 = Son | first2 = Chang Gue | date = 2012-09-01| title = Fatigue severity of patients with idiopathic chronic fatigue compared to healthy subjects | url = http://www.sciencedirect.com/science/article/pii/S0254627213600370 | journal = Journal of Traditional Chinese Medicine|language=en|volume=32|issue=3 | pages = 355–357|doi=10.1016/S0254-6272(13)60037-0|issn=0254-6272}}</ref> - [https://www.sciencedirect.com/science/article/pii/S0254627213600370/pdf?md5=e8df9e93c64cbe130e27bdbf3b0edcc1&pid=1-s2.0-S0254627213600370-main.pdf&_valck=1 (Full text)] * 2013, Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle<ref name="Son2013">{{Cite journal | last = Wawrzyniak | first = Nicholas R. | last2 = Joseph | first2 = Anna-Maria | last3 = Levin | first3 = David G. | last4 = Gundermann | first4 = David M. | last5 = Leeuwenburgh | first5 = Christiaan | last6 = Sandesara | first6 = Bhanuprasad | last7 = Manini | first7 = Todd M. | last8 = Adhihetty | first8 = Peter J.| date = 2016-07-18| title = Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288142/ | journal = Oncotarget|volume=7|issue=33 | pages = 52695–52709|doi=10.18632/oncotarget.10685|issn=1949-2553|pmc=5288142|pmid=27447862}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288142/ (Full text)] * 2013, Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course<ref>{{Cite journal | last = Mørch | first = Kristine | last2 = Hanevik | first2 = Kurt | last3 = Rivenes | first3 = Ann C. | last4 = Bødtker | first4 = Jørn E. | last5 = Næss | first5 = Halvor | last6 = Stubhaug | first6 = Bjarte | last7 = Wensaas | first7 = Knut-Arne | last8 = Rortveit | first8 = Guri | last9 = Eide | first9 = Geir E.| date = 2013-02-12| title = Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course | url = https://doi.org/10.1186/1471-230X-13-28 | journal = BMC Gastroenterology|language=en|volume=13|issue=1 | pages = 28|doi=10.1186/1471-230X-13-28|issn=1471-230X|pmc = 3598369|pmid=23399438}}</ref> - [https://link.springer.com/article/10.1186/1471-230X-13-28 (Full text)] * 2013, An open-label study of effects of acupuncture on chronic fatigue syndrome and idiopathic chronic fatigue: study protocol for a randomized controlled trial<ref name="Kim2013">{{Cite journal | last = Kim | first = Jung-Eun | last2 = Hong | first2 = Kwon-Eui | last3 = Kim | first3 = Hyeong-Jun | last4 = Choi | first4 = Jin-Bong | last5 = Baek | first5 = Yong-Hyeon | last6 = Seo | first6 = Byung-Kwan | last7 = Lee | first7 = Sanghun | last8 = Kang | first8 = Kyung-Won | last9 = Lee | first9 = Min-Hee | date = 2013-05-21| title = An open-label study of effects of acupuncture on chronic fatigue syndrome and idiopathic chronic fatigue: study protocol for a randomized controlled trial | url = https://doi.org/10.1186/1745-6215-14-147 | journal = Trials|volume=14|issue=1|pages=147|doi=10.1186/1745-6215-14-147|issn=1745-6215|pmc = 3663812|pmid=23693129}}</ref> - [https://trialsjournal.biomedcentral.com/articles/10.1186/1745-6215-14-147 (Full text)] * 2014, Chronic fatigue syndrome: A review<ref name="Singh2014" /> [http://www.mjdrdypu.org/article.asp?issn=0975-2870;year=2014;volume=7;issue=4;spage=415;epage=422;aulast=Balachander (Full Text)] * 2016, Metabolic Rate and Perceived Exertion of Walking in Older Adults With Idiopathic Chronic Fatigue<ref name="Valiani2019">{{Cite journal | last = Manini | first = Todd M. | authorlink = | last2 = Knaggs | first2 = JeffreyD. | author-link2 = | last3 = Corbett | first3 = Duane B. | author-link3 = | last4 = Valiani | first4 = Vincenzo | author-link4 = Vincenzo Valiani | author-link5 = | date = 2016-11-01| title = Metabolic Rate and Perceived Exertion of Walking in Older Adults With Idiopathic Chronic Fatigue | url = https://academic.oup.com/biomedgerontology/article/71/11/1444/2577047 | journal = The Journals of Gerontology: Series A|language=en|volume=71|issue=11|pages=1444–1450|doi=10.1093/gerona/glw108|issn=1079-5006|quote=|via=}}</ref> [https://academic.oup.com/biomedgerontology/article/71/11/1444/2577047 (Full text)] * 2019, Differential diagnosis between “chronic fatigue” and “chronic fatigue syndrome”<ref name="Son2019">{{Cite journal | last = Son | first = Chang-Gue | date = Jun 2019| title = Differential diagnosis between "chronic fatigue" and "chronic fatigue syndrome". | url = https://europepmc.org/articles/PMC6522773/ | journal = Integrative medicine research|volume=8|issue=2 | pages = 89–91|doi=10.1016/j.imr.2019.04.005|issn=2213-4220|pmid=31193269|quote=|via=}}</ref> - [https://europepmc.org/articles/PMC6522773/ (Full source)] == See also == * [[Chronic fatigue]] * [[Chronic fatigue syndrome]] * [[Fatigue]] * [[Medically unexplained symptoms]] == Learn more == * [https://www.docsopinion.com/2017/11/08/causes-fatigue-tiredness-chronic-fatigue/ 19 Important Causes of Fatigue – Tiredness and Chronic Fatigue Explained]<ref name=":0" /> == References == {{Reflist}} [[Category:Disease]]
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