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Hypothalamic-pituitary-adrenal axis
(section)
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== Role in human disease == The HPA axis controls our body's responses to physical or emotional stress, and is being investigated as a possible cause for [[Myalgic encephalomyelitis]].<ref>{{Cite web | url = https://www.cdc.gov/me-cfs/about/possible-causes.html | title = Possible Causes {{!}} Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) {{!}} CDC | last = CDC | first = | date = 2017-07-14 | website = [[Centers for Disease Control and Prevention]]|language=en-us|archive-url=|archive-date=|url-status=|access-date=2018-10-05}}</ref> Deficiencies in the HPA axis may play a role in allergies and inflammatory/ autoimmune diseases, such as [[rheumatoid arthritis]] and [[multiple sclerosis]].<ref name="MD2" /><ref name="Otmishi2" /><ref name="Bellavance2" /> The relationship between chronic stress and its concomitant activation of the HPA axis, and dysfunction of the immune system is unclear; studies have found both immunosuppression and hyperactivation of the immune response.<ref name="Padgett2" />
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