Hyperalgesia: Difference between revisions
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'''Hyperalgesia''' is an abnormal increase in sensitivity or an amplification of normally painful or uncomfortable stimulus. A person with hyperalgesia experiences an excessive amount of pain compared to the physical severity of damage or illness in their body.<ref name="Shaikh2010">{{Cite book|last=Shaikh|first=Maliha|last2=Hakim|first2=Alan J|last3=Shenker|first3=Nicholas|date=2010|title=Hypermobility, Fibromyalgia and Chronic Pain|chapter=The physiology of pain|url=https://doi.org/10.1016/B978-0-7020-3005-5.00003-3|publisher=Elsevier|pages=35–52|doi=10.1016/b978-0-7020-3005-5.00003-3|isbn=9780702030055}}</ref> | |||
'''Hyperalgesia''' is an abnormal increase in sensitivity or an amplification of normally painful or uncomfortable stimulus. A person with hyperalgesia experiences an excessive amount of pain compared to the physical severity of damage or illness in their body.<ref>{{Cite | |||
Generalized hyperalgesia is common in [[fibromyalgia]] (FMS) and [[chronic fatigue syndrome]] (ME/CFS) and some studies indicate it may be partly caused by a mechanism in which [[ | Generalized hyperalgesia is common in [[fibromyalgia]] (FMS) and [[chronic fatigue syndrome]] (ME/CFS) and some studies indicate it may be partly caused by a mechanism in which [[microglia]]l accumulation and activation is involved,<ref name="Yasui">{{Cite journal|last=Yasui|first=Masaya|author-link=|last2=Yoshimura|first2=Takashi|author-link2=|last3=Takeuchi|first3=So|author-link3=|last4=Tokizane|first4=Kyohei|author-link4=|last5=Tsuda|first5=Makoto|author-link5=|last6=Inoue|first6=Kazuhide|last7=Kiyama|first7=Hiroshi|date=Sep 2014|title=A Chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation: Microglia-Mediated Pain Under Chronic Stress|url=http://doi.wiley.com/10.1002/glia.22687|journal=Glia|language=en|volume=62|issue=9|pages=1407–1417|doi=10.1002/glia.22687|pmid=24852223|quote=|via=}}</ref> as well as other possible immune system changes, such as complement system product [[Complement C4a|C4a]].<ref name="Polli">{{Cite journal|last=Polli|first=Andrea|author-link=Andrea Polli|last2=Van Oosterwijck|first2=Jessica|author-link2=Jessica Van Oosterwijck|last3=Meeus|first3=Mira|author-link3=Mira Meeus|last4=Lambrecht|first4=Luc|author-link4=|last5=Nijs|first5=Jo|author-link5=Jo Nijs|last6=Ickmans|first6=Kelly|author-link6=Kelly Ickmans|date=2019-01-28|title=Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – a secondary analysis of experimental comparative studies|url=http://www.degruyter.com/view/j/sjpain.2019.19.issue-1/sjpain-2018-0075/sjpain-2018-0075.xml|journal=Scandinavian Journal of Pain|volume=19|issue=1|pages=183–192|doi=10.1515/sjpain-2018-0075|issn=1877-8879|pmid=30325737|quote=|via=}}</ref> | ||
==Symptom recognition == | ==Symptom recognition == | ||
Hypersensitivity to pain is a sensory symptom recognized in the Canadian Consensus Criteria for Myalgic Encephalomyelitis.<ref name="canadianconsensus" /> | Hypersensitivity to pain is a sensory symptom recognized in the [[Canadian Consensus Criteria]] for Myalgic Encephalomyelitis.<ref name="canadianconsensus" /> | ||
== Notable studies == | == Notable studies == | ||
* 2010, Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study<ref>{{Cite journal|last=Meeus|first=Mira|author-link=Mira Meeus|last2=Nijs|first2=Jo|author-link2=Jo Nijs|last3=Huybrechts|first3=Sven|author-link3=|last4=Truijen|first4=Steven|author-link4=|author-link5=|date=Apr 2010|title=Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study|url=http://link.springer.com/10.1007/s10067-009-1339-0|journal=Clinical Rheumatology|language=en|volume=29|issue=4|pages=393–398|doi=10.1007/s10067-009-1339-0|issn=0770-3198|pmid=20077123|quote=|via=}}</ref> | * 2010, Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study<ref>{{Cite journal|last=Meeus|first=Mira|author-link=Mira Meeus|last2=Nijs|first2=Jo|author-link2=Jo Nijs|last3=Huybrechts|first3=Sven|author-link3=|last4=Truijen|first4=Steven|author-link4=|author-link5=|date=Apr 2010|title=Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study|url=http://link.springer.com/10.1007/s10067-009-1339-0|journal=Clinical Rheumatology|language=en|volume=29|issue=4|pages=393–398|doi=10.1007/s10067-009-1339-0|issn=0770-3198|pmid=20077123|quote=|via=}}</ref> | ||
* 2014, A chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation<ref name=" | * 2014, A chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation<ref name="Yasui" /> | ||
* 2019, Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - a secondary analysis of experimental comparative studies<ref name=" | * 2019, Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - a secondary analysis of experimental comparative studies<ref name="Polli" /> | ||
==See also == | ==See also == | ||
| Line 20: | Line 19: | ||
==Learn more == | ==Learn more == | ||
* 2017, [https://www.verywellhealth.com/hyperalgesia-715942 Hyperalgesia Amplified Pain in Fibromyalgia & ME/CFS] | * 2017, [https://www.verywellhealth.com/hyperalgesia-715942 Hyperalgesia Amplified Pain in Fibromyalgia & ME/CFS] - [[Adrienne Dellwo]], Very Well Health | ||
==References == | ==References == | ||
<references> | <references> | ||
<ref name="canadianconsensus"><cite id="CITEREFCarruthersJainDe_MeirleirPeterson2003" class="citation">[[Bruce Carruthers|Carruthers, Bruce M.]]; [[Anil Kumar Jain|Jain, Anil Kumar]]; [[Kenny De Meirleir|De Meirleir, Kenny L.]]; [[Daniel Peterson|Peterson, Daniel L.]]; [[Nancy Klimas|Klimas, Nancy G.]]; [[Martin Lerner|Lerner, A. Martin]]; [[Alison Bested|Bested, Alison C.]]; [[Pierre Flor-Henry|Flor-Henry, Pierre]]; [[Pradip Joshi|Joshi, Pradip]]; [[A C Peter Powles|Powles, A C Peter]]; [[Jeffrey Sherkey|Sherkey, Jeffrey A.]]; [[Marjorie van de Sande|van de Sande, Marjorie I.]] (2003), [http://www.investinme.org/Documents/PDFdocuments/CanadianDefinitionME-CFS.pdf "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols"] <span style="font-size:85%;">(PDF)</span>, ''Journal of Chronic Fatigue Syndrome'', <b>11</b> (2): 7-115, [[Digital object identifier|doi]]:[//doi.org/10.1300%2FJ092v11n01_02 10.1300/J092v11n01_02]</cite><span title="ctx_ver=Z39.88-2004 | <ref name="canadianconsensus"><cite id="CITEREFCarruthersJainDe_MeirleirPeterson2003" class="citation">[[Bruce Carruthers|Carruthers, Bruce M.]]; [[Anil Kumar Jain|Jain, Anil Kumar]]; [[Kenny De Meirleir|De Meirleir, Kenny L.]]; [[Daniel Peterson|Peterson, Daniel L.]]; [[Nancy Klimas|Klimas, Nancy G.]]; [[Martin Lerner|Lerner, A. Martin]]; [[Alison Bested|Bested, Alison C.]]; [[Pierre Flor-Henry|Flor-Henry, Pierre]]; [[Pradip Joshi|Joshi, Pradip]]; [[A C Peter Powles|Powles, A C Peter]]; [[Jeffrey Sherkey|Sherkey, Jeffrey A.]]; [[Marjorie van de Sande|van de Sande, Marjorie I.]] (2003), [http://www.investinme.org/Documents/PDFdocuments/CanadianDefinitionME-CFS.pdf "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols"] <span style="font-size:85%;">(PDF)</span>, ''Journal of Chronic Fatigue Syndrome'', <b>11</b>(2): 7-115, [[Digital object identifier|doi]]:[//doi.org/10.1300%2FJ092v11n01_02 10.1300/J092v11n01_02]</cite><span title="ctx_ver=Z39.88-2004" class="Z3988"></span></ref> | ||
</references> | </references> | ||
[[Category:Signs and symptoms]] | [[Category:Signs and symptoms]] | ||
[[Category:Pain signs and symptoms]] | [[Category:Pain signs and symptoms]] | ||
[[Category:Neurological signs and symptoms]] | [[Category:Neurological signs and symptoms]] | ||
Revision as of 21:17, March 7, 2021
Hyperalgesia is an abnormal increase in sensitivity or an amplification of normally painful or uncomfortable stimulus. A person with hyperalgesia experiences an excessive amount of pain compared to the physical severity of damage or illness in their body.[1]
Generalized hyperalgesia is common in fibromyalgia (FMS) and chronic fatigue syndrome (ME/CFS) and some studies indicate it may be partly caused by a mechanism in which microglial accumulation and activation is involved,[2] as well as other possible immune system changes, such as complement system product C4a.[3]
Symptom recognition[edit | edit source]
Hypersensitivity to pain is a sensory symptom recognized in the Canadian Consensus Criteria for Myalgic Encephalomyelitis.[4]
Notable studies[edit | edit source]
- 2010, Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study[5]
- 2014, A chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation[2]
- 2019, Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - a secondary analysis of experimental comparative studies[3]
See also[edit | edit source]
- Allodynia
- Fibromyalgia
- Pain
- Pain relief (analgesics)
Learn more[edit | edit source]
- 2017, Hyperalgesia Amplified Pain in Fibromyalgia & ME/CFS - Adrienne Dellwo, Very Well Health
References[edit | edit source]
- ↑ Shaikh, Maliha; Hakim, Alan J; Shenker, Nicholas (2010). "The physiology of pain". Hypermobility, Fibromyalgia and Chronic Pain. Elsevier. pp. 35–52. doi:10.1016/b978-0-7020-3005-5.00003-3. ISBN 9780702030055.
- ↑ 2.0 2.1 Yasui, Masaya; Yoshimura, Takashi; Takeuchi, So; Tokizane, Kyohei; Tsuda, Makoto; Inoue, Kazuhide; Kiyama, Hiroshi (September 2014). "A Chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation: Microglia-Mediated Pain Under Chronic Stress". Glia. 62 (9): 1407–1417. doi:10.1002/glia.22687. PMID 24852223.
- ↑ 3.0 3.1 Polli, Andrea; Van Oosterwijck, Jessica; Meeus, Mira; Lambrecht, Luc; Nijs, Jo; Ickmans, Kelly (January 28, 2019). "Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – a secondary analysis of experimental comparative studies". Scandinavian Journal of Pain. 19 (1): 183–192. doi:10.1515/sjpain-2018-0075. ISSN 1877-8879. PMID 30325737.
- ↑ Carruthers, Bruce M.; Jain, Anil Kumar; De Meirleir, Kenny L.; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison C.; Flor-Henry, Pierre; Joshi, Pradip; Powles, A C Peter; Sherkey, Jeffrey A.; van de Sande, Marjorie I. (2003), "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols" (PDF), Journal of Chronic Fatigue Syndrome, 11(2): 7-115, doi:10.1300/J092v11n01_02
- ↑ Meeus, Mira; Nijs, Jo; Huybrechts, Sven; Truijen, Steven (April 2010). "Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study". Clinical Rheumatology. 29 (4): 393–398. doi:10.1007/s10067-009-1339-0. ISSN 0770-3198. PMID 20077123.
