Hyperalgesia: Difference between revisions
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'''Hyperalgesia''' is an abnormal increase in sensitivity or an amplification of normally painful or uncomfortable stimulus. A person with hyperalgesia experiences an excessive amount of pain compared to the physical severity of damage or illness in their body.<ref name="Shaikh2010">{{Cite book|last=Shaikh|first=Maliha|last2=Hakim|first2=Alan J|last3=Shenker|first3=Nicholas|date=2010|title=Hypermobility, Fibromyalgia and Chronic Pain|chapter=The physiology of pain|url=https://doi.org/10.1016/B978-0-7020-3005-5.00003-3|publisher=Elsevier|pages=35–52|doi=10.1016/b978-0-7020-3005-5.00003-3|isbn=9780702030055}}</ref> | '''Hyperalgesia''' is an abnormal increase in sensitivity or an amplification of normally painful or uncomfortable stimulus. A person with hyperalgesia experiences an excessive amount of pain compared to the physical severity of damage or illness in their body.<ref name="Shaikh2010">{{Cite book | last = Shaikh | first = Maliha | last2 = Hakim | first2 = Alan J | last3 = Shenker | first3 = Nicholas | date = 2010 | title=Hypermobility, Fibromyalgia and Chronic Pain|chapter=The physiology of pain | url =https://doi.org/10.1016/B978-0-7020-3005-5.00003-3| publisher = Elsevier | pages = 35–52|doi=10.1016/b978-0-7020-3005-5.00003-3|isbn=9780702030055}}</ref> | ||
Generalized hyperalgesia is common in [[fibromyalgia]] (FMS) and [[chronic fatigue syndrome]] (ME/CFS) and some studies indicate it may be partly caused by a mechanism in which [[microglia]]l accumulation and activation is involved,<ref name="Yasui">{{Cite journal|last=Yasui|first=Masaya| | Generalized hyperalgesia is common in [[fibromyalgia]] (FMS) and [[chronic fatigue syndrome]] (ME/CFS) and some studies indicate it may be partly caused by a mechanism in which [[microglia]]l accumulation and activation is involved,<ref name="Yasui">{{Cite journal | last = Yasui | first = Masaya | authorlink = | last2 = Yoshimura | first2 = Takashi | authorlink2 = | last3 = Takeuchi | first3 = So | authorlink3 = | last4 = Tokizane | first4 = Kyohei | authorlink4 = | last5 = Tsuda | first5 = Makoto | authorlink5 = | last6 = Inoue | first6 = Kazuhide | last7 = Kiyama | first7 = Hiroshi | date = Sep 2014 | title = A Chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation: Microglia-Mediated Pain Under Chronic Stress | url = http://doi.wiley.com/10.1002/glia.22687|journal=Glia|language=en|volume=62|issue=9|pages=1407–1417|doi=10.1002/glia.22687|pmid=24852223|quote=|via=}}</ref> as well as other possible immune system changes, such as complement system product [[Complement C4a|C4a]].<ref name="Polli">{{Cite journal | last = Polli | first = Andrea | authorlink = Andrea Polli | last2 = Van Oosterwijck | first2 = Jessica | authorlink2 = Jessica Van Oosterwijck | last3 = Meeus | first3 = Mira | authorlink3 = Mira Meeus | last4 = Lambrecht | first4 = Luc | authorlink4 = | last5 = Nijs | first5 = Jo | authorlink5 = Jo Nijs | last6 = Ickmans | first6 = Kelly | authorlink6 = Kelly Ickmans | date = 2019-01-28 | title = Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – a secondary analysis of experimental comparative studies | url = http://www.degruyter.com/view/j/sjpain.2019.19.issue-1/sjpain-2018-0075/sjpain-2018-0075.xml|journal=Scandinavian Journal of Pain|volume=19|issue=1|pages=183–192|doi=10.1515/sjpain-2018-0075|issn=1877-8879|pmid=30325737|quote=|via=}}</ref> | ||
==Symptom recognition == | ==Symptom recognition == | ||
Hypersensitivity to pain is a sensory symptom recognized in the [[Canadian Consensus Criteria]] for Myalgic Encephalomyelitis.<ref name="canadianconsensus" /> | Hypersensitivity to pain is a sensory symptom recognized in the [[Canadian Consensus Criteria]] for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, and hyperalgesia is one of the examples of significant pain included in the [[International Consensus Criteria]] for Myalgic Encephalomyelitis.<ref name="canadianconsensus">{{Cite journal | last1 = Carruthers | first1 = Bruce M. | authorlink1 = Bruce Carruthers | last2 = Jain | first2 = Anil Kumar | authorlink2 = Anil Kumar Jain | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Peterson | first4 = Daniel L. | authorlink4 = Daniel Peterson | last5 = Klimas | first5 = Nancy G. | authorlink5 = Nancy Klimas | last6 = Lerner | first6 = A. Martin | authorlink6 = Martin Lerner | last7 = Bested | first7 = Alison C. | authorlink7 = Alison Bested | last8 = Flor-Henry | first8 = Pierre | authorlink8 = Pierre Flor-Henry | last9 = Joshi | first9 = Pradip | author-link9 = Pradip Joshi | last10 = Powles | first10 = AC Peter | authorlink10 = A C Peter Powles | last11 = Sherkey | first11 = Jeffrey A. | authorlink11 = Jeffrey Sherkey | last12 = van de Sande | first12 = Marjorie I. | authorlink12 = Marjorie van de Sande | title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols| journal = Journal of Chronic Fatigue Syndrome | volume = 11 | issue = 2 | pages = 7-115 | date = 2003 | pmid = | doi = 10.1300/J092v11n01_02| url = http://www.investinme.org/Documents/PDFdocuments/CanadianDefinitionME-CFS.pdf}}</ref><ref name="ICC2011primer">{{citation | last1 = Carruthers | first1 = BM | authorlink1 = Bruce Carruthers | last2 = van de Sande | first2 = MI | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = KL | authorlink3 = Kenny de Meirleir | last4 = Klimas | first4 = NG | authorlink4 = Nancy Klimas | last5 = Broderick | first5 = G | authorlink5 = Gordon Broderick | last6 = Mitchell | first6 = T | authorlink6 = Terry Mitchell | last7 = Staines | first7 = D | authorlink7 = Donald Staines | last8 = Powles | first8 = ACP | authorlink8 = A C Peter Powles | last9 = Speight | first9 = N | author-link9 = Nigel Speight | last10 = Vallings | first10 = R | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = L | authorlink11 = Lucinda Bateman | last12 = Bell | first12 = DS | authorlink12 = David Bell | last13 = Carlo-Stella | first13 = N | authorlink13 = Nicoletta Carlo-Stella | last14 = Chia | first14 = J | authorlink14 = John Chia | last15 = Darragh | first15 = A | authorlink15 = Austin Darragh | last16 = Gerken | first16 = A | authorlink16 = Anne Gerken | last17 = Jo | first17 = D | authorlink17 = Daehyun Jo | last18 = Lewis | first18 = DP | authorlink18 = Donald Lewis | last19 = Light | first19 = AR | authorlink19 = Alan Light | last20 = Light | first20 = KC | authorlink20 = Kathleen Light | last21 = Marshall-Gradisnik | first21 = S | authorlink21 = Sonya Marshall-Gradisnik | last22 = McLaren-Howard | first22 = J | authorlink22 = John McLaren-Howard | last23 = Mena | first23 = I | authorlink23 = Ismael Mena | last24 = Miwa | first24 = K | authorlink24 = Kunihisa Miwa | last25 = Murovska | first25 = M | authorlink25= Modra Murovska | last26 = Stevens | first26 = SR | authorlink26 = Staci Stevens | title = Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners | date = 2012 | ||
| isbn = 978-0-9739335-3-6 | url = http://www.investinme.org/Documents/Guidelines/Myalgic%20Encephalomyelitis%20International%20Consensus%20Primer%20-2012-11-26.pdf }}</ref> | |||
== Notable studies == | == Notable studies == | ||
* 2010, Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study<ref>{{Cite journal|last=Meeus|first=Mira| | * 2010, Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study<ref>{{Cite journal | last = Meeus | first = Mira | authorlink = Mira Meeus | last2 = Nijs | first2 = Jo | authorlink2 = Jo Nijs | last3 = Huybrechts | first3 = Sven | authorlink3 = | last4 = Truijen | first4 = Steven | date = Apr 2010 | title = Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study | url = http://link.springer.com/10.1007/s10067-009-1339-0|journal=Clinical Rheumatology|language=en|volume=29|issue=4 | pages = 393–398|doi=10.1007/s10067-009-1339-0|issn=0770-3198|pmid=20077123|quote=|via=}}</ref> | ||
* 2014, A chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation<ref name="Yasui" /> | * 2014, A chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation<ref name="Yasui" /> | ||
* 2019, Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - a secondary analysis of experimental comparative studies<ref name="Polli" /> | * 2019, Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - a secondary analysis of experimental comparative studies<ref name="Polli" /> | ||
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==Learn more == | ==Learn more == | ||
* | * [https://www.webmd.com/pain-management/what-is-hyperalgesia Hyperalgesia: Causes, Symptoms, Treatment, and More] - WebMD | ||
*[https://www.iasp-pain.org/resources/fact-sheets/allodynia-and-hyperalgesia-in-neuropathic-pain/ Allodynia and Hyperalgesia in Neuropathic Pain Fact Sheet] - International Association for the Study of Pain | |||
==References == | ==References == | ||
{{Reflist}} | |||
[[Category:Signs and symptoms]] | [[Category:Signs and symptoms]] | ||
[[Category:Pain signs and symptoms]] | [[Category:Pain signs and symptoms]] | ||
[[Category:Neurological signs and symptoms]] | [[Category:Neurological signs and symptoms]] | ||
Latest revision as of 17:04, April 2, 2023
Hyperalgesia is an abnormal increase in sensitivity or an amplification of normally painful or uncomfortable stimulus. A person with hyperalgesia experiences an excessive amount of pain compared to the physical severity of damage or illness in their body.[1]
Generalized hyperalgesia is common in fibromyalgia (FMS) and chronic fatigue syndrome (ME/CFS) and some studies indicate it may be partly caused by a mechanism in which microglial accumulation and activation is involved,[2] as well as other possible immune system changes, such as complement system product C4a.[3]
Symptom recognition[edit | edit source]
Hypersensitivity to pain is a sensory symptom recognized in the Canadian Consensus Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, and hyperalgesia is one of the examples of significant pain included in the International Consensus Criteria for Myalgic Encephalomyelitis.[4][5]
Notable studies[edit | edit source]
- 2010, Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study[6]
- 2014, A chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation[2]
- 2019, Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - a secondary analysis of experimental comparative studies[3]
See also[edit | edit source]
- Allodynia
- Fibromyalgia
- Pain
- Pain relief (analgesics)
Learn more[edit | edit source]
- Hyperalgesia: Causes, Symptoms, Treatment, and More - WebMD
- Allodynia and Hyperalgesia in Neuropathic Pain Fact Sheet - International Association for the Study of Pain
References[edit | edit source]
- ↑ Shaikh, Maliha; Hakim, Alan J; Shenker, Nicholas (2010). "The physiology of pain". Hypermobility, Fibromyalgia and Chronic Pain. Elsevier. pp. 35–52. doi:10.1016/b978-0-7020-3005-5.00003-3. ISBN 9780702030055.
- ↑ 2.0 2.1 Yasui, Masaya; Yoshimura, Takashi; Takeuchi, So; Tokizane, Kyohei; Tsuda, Makoto; Inoue, Kazuhide; Kiyama, Hiroshi (September 2014). "A Chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation: Microglia-Mediated Pain Under Chronic Stress". Glia. 62 (9): 1407–1417. doi:10.1002/glia.22687. PMID 24852223.
- ↑ 3.0 3.1 Polli, Andrea; Van Oosterwijck, Jessica; Meeus, Mira; Lambrecht, Luc; Nijs, Jo; Ickmans, Kelly (January 28, 2019). "Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – a secondary analysis of experimental comparative studies". Scandinavian Journal of Pain. 19 (1): 183–192. doi:10.1515/sjpain-2018-0075. ISSN 1877-8879. PMID 30325737.
- ↑ Carruthers, Bruce M.; Jain, Anil Kumar; De Meirleir, Kenny L.; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison C.; Flor-Henry, Pierre; Joshi, Pradip; Powles, AC Peter; Sherkey, Jeffrey A.; van de Sande, Marjorie I. (2003). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols" (PDF). Journal of Chronic Fatigue Syndrome. 11 (2): 7–115. doi:10.1300/J092v11n01_02.
- ↑ Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6
- ↑ Meeus, Mira; Nijs, Jo; Huybrechts, Sven; Truijen, Steven (April 2010). "Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study". Clinical Rheumatology. 29 (4): 393–398. doi:10.1007/s10067-009-1339-0. ISSN 0770-3198. PMID 20077123.
