Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
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Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Funding[edit | edit source]
Grants and gifts supporting this work came from:
- Solve ME/CFS Initiative (Ramsay Research Award)
- HHV-6 Foundation (to B.K.P.)
- the University of California San Diego Christini Fund
- Lennox Foundation
- JMS Fund
- Khosla Foundation
- Westreich Foundation,
- Malone Foundation (to R.K.N.)
plus "grassroots support from over 2000 individuals who have each provided gifts in the past year to support Naviaux laboratory and Prusty laboratory research".[1]
Results[edit | edit source]
- HHV-6 reactivation was shown to cause mitochondria dysfunction in patients with ME/CFS
- antiviral activity was found in the blood serum of patients with ME/CFS
- the antiviral activity was "tightly associated with an activity that fragments the mitochondrial network and decreases cellular energy (ATP) production"
Criticism[edit | edit source]
Investigators[edit | edit source]
- Philipp Schreiner
- Thomas Harrer
- Carmen Scheibenbogen
- Stephanie Lamer
- Andreas Schlosser
- Robert Naviaux
- Bhupesh Prusty
Commentary[edit | edit source]
This paper will be a paradigm shift in our understanding of potential infectious causes behind ME/CFS. Human herpesvirus 6 and HHV-7 have long been thought to play a role in this disease, but there was hardly any causative mechanism known before — Bhupesh Prusty
News coverage[edit | edit source]
See also[edit | edit source]
Learn more[edit | edit source]
- Press release: For ME/CFS Patients, Viral Immunities Come at a Devastating, Lifelong Cost
- Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (Full text)
References[edit | edit source]
- ↑ Schreiner, Philipp; Harrer, Thomas; Scheibenbogen, Carmen; Lamer, Stephanie; Schlosser, Andreas; Naviaux, Robert K.; Prusty, Bhupesh K. (April 1, 2020). "Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". ImmunoHorizons. 4 (4): 201–215. doi:10.4049/immunohorizons.2000006. ISSN 2573-7732. PMID 32327453.