Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Histamine
(section)
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
==Modulating histamine levels== Histamine is broken down by an enzyme called [[diamine oxidase]] (DAO), which is found mainly in the [[gastrointestinal tract]] and in [[pregnant]] women, the [[placenta]]. Nutritional deficiencies in [[Vitamin C]], [[magnesium]], [[Vitamin B6]] and [[copper]] β all DAO cofactors β can decrease DAO activity. [[Vitamin C]] reduces blood histamine levels,<ref name="clemetson1980">{{Citation| issn = 0022-3166| volume = 110 | issue = 4| pages = 662β668| last = Clemetson | first = C.A. | title = Histamine and ascorbic acid in human blood| journal = The Journal of Nutrition | date = April 1980 | pmid = 7365537}}</ref><ref name="johnston1992">{{Citation| issn = 0731-5724| volume = 11 | issue = 2| pages = 172β176| last1 = Johnston | first1 = C.S. | last2 = Martin | first2 = L.J. | last3 = Cai | first3 = X.| title = Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis| journal = Journal of the American College of Nutrition | date = April 1992 | pmid = 1578094}}</ref><ref>{{Cite journal | last = Johnston | first = CS | date = December 1996 | title = Vitamin C depletion is associated with alterations in blood histamine and plasma free carnitine in adults | url = https://www.ncbi.nlm.nih.gov/pubmed/8951736|journal=J Am Coll Nutr.|volume=|pages=|via=}}</ref> potentially through several mechanisms: by inhibiting mast cell production; by increasing [[diamine oxidase]] (an [[enzyme]] that breaks down histamine); by inhibiting mast cell degranulation (and the release of histamine in the first place),<ref name=":0">{{Cite journal | last = Mio | first = M | date = 1999 | title = Ultraviolet B (UVB) light-induced histamine release from rat peritoneal mast cells and its augmentation by certain phenothiazine compounds | url = https://www.sciencedirect.com/science/article/pii/S0162310998000538|journal=Immunopharmacology|volume=|pages=|via=}}</ref> and by inhibiting [[histidine decarboxylase]] (the enzyme that forms histamine).<ref>{{Cite journal | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903110/ | title = Pharmacological treatment options for mast cell activation disease | last = Molderings | first = Gerhard | date = 2016 | journal=Naunyn Schmiedebergs Arch Pharmacol|volume=|pages=|via=}}</ref> [[Manganese]] and [[zinc]] can also prevent the release of histamine from [[mast cell]]s.
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
This page is a member of 2 hidden categories:
Category:All articles with unsourced statements
Category:Articles with unsourced statements from unknown year
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs