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Herpesviruses
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==Chronic fatigue syndrome== It is unclear whether herpesviruses associated with [[Chronic fatigue syndrome]] play an etiological role or are "bystanders" – opportunistic reactivations under a state of immune dysregulation. In the [[1984 Incline Village chronic fatigue syndrome outbreak]], [[Gary Holmes]] found that patients with what his team hypothesized was [[chronic Epstein-Barr virus|chronic Epstein-Barr]] had elevated antibody titers to [[Epstein-Barr virus]], [[cytomegalovirus]], [[herpes simplex]] and [[measles]] viruses than age-matched controls.<ref>{{Cite journal | url = https://jamanetwork.com/journals/jama/article-abstract/365861 | title = A Cluster of Patients With a Chronic Mononucleosis-like Syndrome Is Epstein-Barr Virus the Cause? | last = Homes | first = Gary P | date = May 1, 1987 |journal=Journal of the American Medical Association|volume=257 | pages = 2297-2302 |via=}}</ref> However, the study cohort was defined as patients who had experienced excessive fatigue between January 1 and September 15. A prospective study of 250 primary care patients revealed a higher prevalence of [[chronic fatigue syndrome]] after infectious [[mononucleosis]] (glandular fever) when compared to an ordinary upper respiratory tract infection.<ref>{{Cite journal | last = White | first = P.D. | last2 = Thomas | first2 = J.M. | last3 = Amess | first3 = J. | last4 = Crawford | first4 =D.H. | last5 = Grover | first5 = S.A. | last6 = Kangro | first6 = H.O. | last7 = Clare | first7 = A.W. | date = Dec 1998 | title = Incidence, risk and prognosis of acute and chronic fatigue syndromes and psychiatric disorders after glandular fever |url =https://www.ncbi.nlm.nih.gov/pubmed/9926075|journal=The British Journal of Psychiatry: The Journal of Mental Science|volume=173 | pages = 475–481|issn=0007-1250|pmid=9926075}}</ref> Anti-early antigen titers to Epstein-Barr virus were elevated in CFS patients and associated with worse symptoms.<ref>{{Cite journal | last = Schmaling | first = K.B. | last2 = Jones | first2 = J.F. | date = Jan 1996 | title = MMPI profiles of patients with chronic fatigue syndrome | url = https://www.ncbi.nlm.nih.gov/pubmed/8730646|journal=Journal of Psychosomatic Research|volume=40|issue=1 | pages = 67–74|issn=0022-3999|pmid=8730646}}</ref>
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