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Hashimoto's thyroiditis (hypothyroidism)
(section)
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==HLA risk alleles== Variations in several human leukocyte antigen (HLA) complex family of genes have been studied as possible risk factors for Hashimoto thyroiditis. Associations have been found between Hashimoto's disease and the following HLA alleles:<ref>{{Cite web | url=https://selfdecode.com/blog/article/hla-drb1-thyroid-autoimmunity-92/ | title = SelfDecode {{!}} Blog|website=selfdecode.com|access-date=2020-08-26}}</ref><ref>{{Cite journal | last = Tashiro | first = Ryosuke | last2 = Niizuma | first2 = Kuniyasu | last3 = Khor | first3 = Seik-Soon | last4 = Tokunaga | first4 = Katsushi | last5 = Fujimura | first5 = Miki | last6 = Sakata | first6 = Hiroyuki | last7 = Endo | first7 = Hidenori | last8 = Inoko | first8 = Hidetoshi | last9 = Ogasawara | first9 = Koetsu | date = 2019-08-14 | title = Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its association with autoimmune thyroid disease: A case-control study| url = https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0220858|journal=PLOS ONE|language=en|volume=14|issue=8| pages = e0220858|doi=10.1371/journal.pone.0220858|issn=1932-6203|pmc = 6693760|pmid=31412073}}</ref><ref name="Lande">{{Cite journal | last = Lande | first = Asgeir | last2 = Fluge | first2 = Øystein | last3 = Strand | first3 = Elin B. | last4 = Flåm | first4 = Siri T. | last5 = Sosa | first5 = DaysiD. | last6 = Mella | first6 = Olav | last7 = Egeland | first7 = Torstein | last8 = Saugstad | first8 = OlaD. | last9 = Lie | first9 = Benedicte A. | date = 2020-03-24 | title = Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)| url = https://www.nature.com/articles/s41598-020-62157-x|journal=Scientific Reports|language=en|volume=10|issue=1 | pages = 5267|doi=10.1038/s41598-020-62157-x|issn=2045-2322}}</ref> * C*07:04 * DQB1*03:03 * DRB1 * DRB1*04:10 === ME/CFS and Hashimoto's genetics=== In a large 2020 study, CFS patients with [[Human leukocyte antigen genes|Human Leukocyte Antigen]] (HLA) risk alleles ('''C*07:04''' and '''DQB1*03:03''') were found to share the following [[Autoimmune disease|autoimmune diseases]], ordered by frequency:<ref name="Lande" /> # [[Hashimoto's thyroiditis]] # Psoriasis # [[Rheumatoid arthritis]] # Alopecia areata # Crohn’s disease or [[ulcerative colitis]]
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