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Graded activity therapy
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==PACE trial== The controversial PACE trial was the largest ever trial of graded exercise therapy, after a Freedom of Information Act request was granted in 2016, the full but anonymised data from the PACE trial patients was published, showing that graded exercise therapy did not result in clinically significant improvements in ME/CFS patients.<ref name="wilshire2018">{{Cite journal | last = Wilshire | first = Carolyn E. | authorlink = Carolyn Wilshire | last2 = Kindlon | first2 = Tom | authorlink2 = Tom Kindlon | last3 = Courtney | first3 = Robert | authorlink3 = Robert Courtney | last4 = Matthees | first4 = Alem | authorlink4 = Alem Matthees | last5 = Tuller | first5 = David | authorlink5 = David Tuller | last6 = Geraghty | first6 = Keith | authorlink6 = Keith Geraghty | last7 = Levin | first7 = Bruce | authorlink7 = Bruce Levin | date = 2018-03-22 | title = Rethinking the treatment of chronic fatigue syndrome—a reanalysis and evaluation of findings from a recent major trial of graded exercise and CBT| url = https://bmcpsychology.biomedcentral.com/articles/10.1186/s40359-018-0218-3|journal=BMC Psychology|language=en|volume=6|issue=1 | pages = |doi=10.1186/s40359-018-0218-3|issn=2050-7283|pmc=5863477|pmid=29562932|quote=|via=}}</ref><ref name="wilshire2016">{{Cite journal | last = Wilshire | first = Carolyn | last2 = Kindlon | first2 = Tom | last3 = Matthees | first3 = Alem | last4 = McGrath | first4 = Simon | date = 2016-12-14 | title = Can patients with chronic fatigue syndrome really recover after graded exercise or cognitive behavioural therapy? A critical commentary and preliminary re-analysis of the PACE trial| url = http://www.tandfonline.com/doi/full/10.1080/21641846.2017.1259724|journal = Fatigue: Biomedicine, Health & Behavior |language=en|volume=5|issue=1 | pages = 43–56|doi=10.1080/21641846.2017.1259724|issn=2164-1846}}</ref> Graded Activity Therapy is considered identical or nearly identical to graded exercise therapy by PACE trial authors [[Peter White]], [[Michael Sharpe]], [[Lucy Clark]], and other promoters of the [[Biopsychosocial model]] of ME/CFS, a model and treatment approaches now abandoned by the [[Centers for Disease Control|CDC]] in the [[United States]],<ref name="CDC-IOM-SEIDcriteria">{{Cite web | url = https://www.cdc.gov/me-cfs/healthcare-providers/diagnosis/iom-2015-diagnostic-criteria.html | title = IOM 2015 Diagnostic Criteria {{!}} Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|website=[[Centers for Disease Control and Prevention]] | date = Jan 27, 2021|access-date = 2021-02-25}}</ref><ref name="CDCsymptoms">{{Cite web | url = https://www.cdc.gov/me-cfs/symptoms-diagnosis/symptoms.html | title = Symptoms {{!}} Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|website=[[Centers for Disease Control and Prevention]] | date = Jan 27, 2021|access-date = 2021-02-25}}</ref> the Dutch Health Council in the [[Netherlands]],<ref name="Twisk, 20180516">{{Cite journal | last1 = Twisk | first1 = Frank | authorlink1 = Frank Twisk| title = Dutch Health Council advisory report on Myalgic Encephalomyelitis and Chronic Fatigue Syndrome: Taking the wrong turn | journal = [[Diagnostics]] | volume = 8 | issue = 2 | date = 2018 | doi = 10.3390/diagnostics8020034}}</ref> and by NICE and the NHS in [[England]] and [[Wales]].<ref name="ng206">{{Cite web | url = https://www.nice.org.uk/guidance/ng206 | title = Myalgic Encephalomyelitis (or Encephalopathy)/Chronic Fatigue Syndrome:diagnosis and management. NICE guideline. | last = NICE Guideline Development Group | first = | authorlink = | publisher = [[National Institute for Health and Care Excellence]] | date = 2021-10-29}}</ref>
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