Gordon Broderick: Difference between revisions
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*Doctorate - Chemical Engineering from the University of Montreal | *Doctorate - Chemical Engineering from the University of Montreal | ||
*Post-doctorate - McGill’s School of Computer Science in cancer genomics | *Post-doctorate - McGill’s School of Computer Science in cancer genomics | ||
*Research fellowship - Computational Biochemistry at the University of Alberta<ref name=":0">{{Cite web|url=http://www.nova.edu/nim/images/dr-gordon-broderick.html|title=NOVA bio|last=|first=|date=|website=|archive-url=|archive-date=|url-status=|access-date=}}</ref> | *Research fellowship - Computational Biochemistry at the University of Alberta<ref name=":0">{{Cite web | url=http://www.nova.edu/nim/images/dr-gordon-broderick.html | title = NOVA bio | last = | first = | date = |website=|archive-url=|archive-date=|url-status=|access-date=}}</ref> | ||
==International Consensus Criteria== | ==International Consensus Criteria== | ||
Dr Broderick participated in the team that authored the 2011 case definition, [[International Consensus Criteria]] (ICC).<ref>{{Cite journal|last=Carruthers|first=Bruce M.| | Dr Broderick participated in the team that authored the 2011 case definition, [[International Consensus Criteria]] (ICC).<ref>{{Cite journal | last = Carruthers | first = Bruce M. | authorlink = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = Kenny L. | authorlink3=Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | authorlink4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | authorlink5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | authorlink6 = Terry Mitchell | last7 = Staines | first7 = Donald | author-link7 = Donald Staines | last8 = Powles | first8 = A.C. Peter | author-link8 = A C Peter Powles | last9 = Speight | first9 = Nigel | author-link9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | authorlink11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | authorlink12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | authorlink14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | authorlink15 = John Chia | last16 = Darragh | first16 = Austin | authorlink16 = Austin Darragh | last17 = Jo | first17 = Daehyun | authorlink17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria| url = https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4 | pages = 327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> | ||
==Open Letter to ''The Lancet''== | ==Open Letter to ''The Lancet''== | ||
Two [[open letter to the Lancet | open letters to the editor of ''The Lancet'']] urged the editor to commission a fully independent review of the [[PACE trial]], which the journal had published in 2011. In 2016, Dr. Broderick, along with 41 colleagues in the [[ME/CFS]] field, signed the second letter. | Two [[open letter to the Lancet | open letters to the editor of ''The Lancet'']] urged the editor to commission a fully independent review of the [[PACE trial]], which the journal had published in 2011. In 2016, Dr. Broderick, along with 41 colleagues in the [[ME/CFS]] field, signed the second letter. | ||
*10 February 2016, [http://www.virology.ws/2016/02/10/open-letter-lancet-again/ An open letter to The Lancet, again - Virology blog]<ref>{{Cite web|url=http://www.virology.ws/2016/02/10/open-letter-lancet-again/|title=An open letter to The Lancet, again|last=Tuller|first=Date|date=Feb 10, 2016|website=[[Virology blog]]|language=en-US|archive-url=|archive-date=|url-status=|access-date=2018-08-14}}</ref> | *10 February 2016, [http://www.virology.ws/2016/02/10/open-letter-lancet-again/ An open letter to The Lancet, again - Virology blog]<ref>{{Cite web | url=http://www.virology.ws/2016/02/10/open-letter-lancet-again/ | title = An open letter to The Lancet, again | last = Tuller | first = Date | date = Feb 10, 2016 | website = [[Virology blog]]|language=en-US|archive-url=|archive-date=|url-status=|access-date=2018-08-14}}</ref> | ||
==Notable studies in ME/CFS== | ==Notable studies in ME/CFS== | ||
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*2008, Evidence of inflammatory immune signaling in chronic fatigue syndrome: A pilot study of [[gene expression]] in peripheral blood.<ref name="Aspler, 2008" /> [http://psycnet.apa.org/record/2008-15631-001 (Abstract)] | *2008, Evidence of inflammatory immune signaling in chronic fatigue syndrome: A pilot study of [[gene expression]] in peripheral blood.<ref name="Aspler, 2008" /> [http://psycnet.apa.org/record/2008-15631-001 (Abstract)] | ||
*2008, Neuroendocrine and immune network remodeling in chronic fatigue syndrome: an exploratory analysis<ref name="Fuite, 2010" /> [https://www.sciencedirect.com/science/article/pii/S0888754308001948?via%3Dihub (Full Text)] | *2008, Neuroendocrine and immune network remodeling in chronic fatigue syndrome: an exploratory analysis<ref name="Fuite, 2010" /> [https://www.sciencedirect.com/science/article/pii/S0888754308001948?via%3Dihub (Full Text)] | ||
*2010, [[Biomarker]]s in Chronic Fatigue Syndrome: Evaluation of [[NKC|Natural Killer Cell]] Function and Dipeptidyl Peptidase IV/CD26<ref>{{Cite journal|last=Fletcher|first=Mary A.| | *2010, [[Biomarker]]s in Chronic Fatigue Syndrome: Evaluation of [[NKC|Natural Killer Cell]] Function and Dipeptidyl Peptidase IV/CD26<ref>{{Cite journal | last = Fletcher | first = Mary A. | authorlink = Mary Ann Fletcher | last2 = Zeng | first2 = Xiao R. | authorlink2 = | last3 = Maher | first3 = Kevin | authorlink3 = | last4 = Levis | first4 = Silvina | authorlink4 = | last5 = Hurwitz | first5 = Barry | authorlink5 = | last6 = Antoni | first6 = Michael | authorlink6 = Michael Antoni | last7 = Broderick | first7 = Gordon | authorlink7 = Gordon Broderick | last8 = Klimas | first8 = Nancy G. | author-link8 = Nancy Klimas | date = 2010-05-25|editor-last = Unutmaz|editor-first = Derya | title = Biomarkers in Chronic Fatigue Syndrome: Evaluation of Natural Killer Cell Function and Dipeptidyl Peptidase IV/CD26| url = https://dx.plos.org/10.1371/journal.pone.0010817|journal=PLoS ONE|language=en|volume=5|issue=5| pages = e10817|doi=10.1371/journal.pone.0010817|issn=1932-6203|pmc=2876037|pmid=20520837|access-date=|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876037/ (Full Text)] | ||
*2010, A Formal Analysis of Cytokine Networks in Chronic Fatigue Syndrome<ref name="Broderick, 2010" /> | *2010, A Formal Analysis of Cytokine Networks in Chronic Fatigue Syndrome<ref name="Broderick, 2010" /> | ||
*2010, [[Cytokines]] across the night in chronic fatigue syndrome with and without [[fibromyalgia]]<ref name="Nakamura, 2010" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849324/ (Full Text)] | *2010, [[Cytokines]] across the night in chronic fatigue syndrome with and without [[fibromyalgia]]<ref name="Nakamura, 2010" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849324/ (Full Text)] | ||
*2010, Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome<ref>{{Citation|last1=Fletcher|first1=Mary Ann| | *2010, Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome<ref>{{Citation | last1 = Fletcher | first1 = Mary Ann | authorlink = Mary Ann Fletcher | last2 = Rosenthal | first2 = Martin | last3 = Antoni | first3 = Michael | authorlink3 =Michael Antoni | last4 = Ironson | first4 = Gail | last5 = Zeng | first5 = Xiao R | last6 = Barnes | first6 = Zachary | authorlink6 = Zachary Barnes | last7 = Harvey | first7 = Jeanna M | authorlink7 = Jeanna Harvey | last8 = Hurwitz | first8 = Barry | last9 = Levis | first9 = Silvina | last10 = Broderick | first10 = Gordon | authorlink10=Gordon Broderick | last11 = Klimas | first11 = Nancy G | authorlink11 = Nancy Klimas | title = Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome|journal = Behavioral and Brain Functions| volume = 6 | issue = 76| page = | date = 2010|doi= 10.1186/1744-9081-6-76}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024290/ (Full Text)] | ||
*2011, Myalgic encephalomyelitis: International Consensus Criteria<ref>{{Cite journal|last=Carruthers|first=Bruce M.| | *2011, Myalgic encephalomyelitis: International Consensus Criteria<ref>{{Cite journal | last = Carruthers | first = Bruce M. | authorlink = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = Kenny L. | authorlink3=Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | author-link4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | authorlink5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | authorlink6 = Terry Mitchell | last7 = Staines | first7 = Donald | author-link7 = Donald Staines | last8 = Powles | first8 = A.C. Peter | author-link8 = A C Peter Powles | last9 = Speight | first9 = Nigel | author-link9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | authorlink11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | authorlink12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | authorlink14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | authorlink15 = John Chia | last16 = Darragh | first16 = Austin | authorlink16 = Austin Darragh | last17 = Jo | first17 = Daehyun | authorlink17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria| url = https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4 | pages = 327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> | ||
*2012, Biomarkers for chronic fatigue.<ref name="Klimas, 2012" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373648/ (Full Text)] | *2012, Biomarkers for chronic fatigue.<ref name="Klimas, 2012" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373648/ (Full Text)] | ||
*2012, Cytokine expression profiles of immune imbalance in post-[[mononucleosis]] chronic fatigue<ref name="Broderick, 2012" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480896/ (Full Text)] | *2012, Cytokine expression profiles of immune imbalance in post-[[mononucleosis]] chronic fatigue<ref name="Broderick, 2012" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480896/ (Full Text)] | ||
*2014, A Role for Homeostatic Drive in the Perpetuation of Complex Chronic Illness: [[Gulf War Illness]] and Chronic Fatigue Syndrome<ref>{{Citation | *2014, A Role for Homeostatic Drive in the Perpetuation of Complex Chronic Illness: [[Gulf War Illness]] and Chronic Fatigue Syndrome<ref>{{Citation | last1 = Craddock | first1 = Travis J.A. | authorlink1 = Travis Craddock | last2 = Fritsch | first2 = Paul | authorlink2 = | last3 = Rice, Jr | first3 = Mark A. | authorlink3 = | last4 = del Rosario | first4 = Ryan M. | authorlink4 = | last5 = Miller | first5 = Diane B. | authorlink5 = | last6 = Fletcher | first6 = Mary Ann | authorlink6 = Mary Ann Fletcher | last7 = Klimas | first7 = Nancy G. | authorlink7 = Nancy Klimas | last8 = Broderick | first8 = Gordon | author-link8 = Gordon Broderick | title = A Role for Homeostatic Drive in the Perpetuation of Complex Chronic Illness: Gulf War Illness and Chronic Fatigue Syndrome | journal = PLOS One | volume = 9 | issue = 1 | page = e84839 | date = 2014 | pmid = | doi = 10.1371/journal.pone.0084839 }}</ref> [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084839 (Full Text)] | ||
| last1 | *2015, Using [[gene expression]] signatures to identify novel treatment strategies in gulf war illness<ref>{{Cite journal | last = Craddock | first = Travis J.A. | last2 = Harvey | first2 = Jeanna M. | last3 = Nathanson | first3 = Lubov | last4 = Barnes | first4 = Zachary M. | last5 = Klimas | first5 = Nancy G. | last6 = Fletcher | first6 = Mary Ann | last7 = Broderick | first7 = Gordon | date = 2015-07-09 | title = Using gene expression signatures to identify novel treatment strategies in gulf war illness| url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495687/|journal=BMC Medical Genomics|volume=8|doi=10.1186/s12920-015-0111-3|issn=1755-8794|pmc=4495687|pmid=26156520|issue= | pages = |quote= | author-link = Travis Craddock | authorlink2 = Jeanna Harvey | authorlink3 = Lubov Nathanson | authorlink4 = Zachary Barnes | authorlink5 = Nancy Klimas|via= | authorlink6 = Mary Ann Fletcher | authorlink7 = Gordon Broderick}}</ref> - [https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12920-015-0111-3 (Full text)] | ||
| last2 | *2016, Tracking post-infectious fatigue in clinic using routine Lab tests<ref name="Harvey2016">{{Cite journal | last = Harvey | first = Jeanna M. | authorlink = Jeanna Harvey | last2 = Broderick | first2 = Gordon | authorlink2 = Gordon Broderick | last3 = Bowie | first3 = Alanna | authorlink3 = Alanna Bowie | last4 = Barnes | first4 = Zachary M. | authorlink4 = Zachary Barnes | last5 = Katz | first5 = Ben Z. | authorlink5 = Ben Katz | last6 = O'Gorman | first6 = Maurice R.G. | author-link6 = Maurice O'Gorman | last7 = Vernon | first7 = SuzanneD. | authorlink7 = Suzanne Vernon | last8 = Fletcher | first8 = Mary Ann | author-link8 = Mary Ann Fletcher | last9 = Klimas | first9 = Nancy G. | author-link9 = Nancy Klimas | date = 2016-04-26 | title = Tracking post-infectious fatigue in clinic using routine Lab tests| url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847210/|journal=BMC Pediatrics|doi=10.1186/s12887-016-0596-8|issn=1471-2431|pmc=4847210|pmid=27118537|volume=15|issue= | pages = 54|quote=}}</ref> [https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-016-0596-8 (Full Text)] | ||
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*2015, Using [[gene expression]] signatures to identify novel treatment strategies in gulf war illness<ref>{{Cite journal|last=Craddock|first=Travis J.A.|last2=Harvey|first2=Jeanna M.|last3=Nathanson|first3=Lubov|last4=Barnes|first4=Zachary M.|last5=Klimas|first5=Nancy G.|last6=Fletcher|first6=Mary Ann|last7=Broderick|first7=Gordon|date=2015-07-09|title=Using gene expression signatures to identify novel treatment strategies in gulf war illness|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495687/|journal=BMC Medical Genomics|volume=8|doi=10.1186/s12920-015-0111-3|issn=1755-8794|pmc=4495687|pmid=26156520|issue=|pages=|quote=|author-link=Travis Craddock| | |||
*2016, Tracking post-infectious fatigue in clinic using routine Lab tests<ref>{{Cite journal|last=Harvey|first=Jeanna M.|last2=Broderick|first2=Gordon|last3=Bowie|first3=Alanna|last4=Barnes|first4=Zachary M.|last5=Katz|first5=Ben Z.|last6= | |||
*2016, Illness progression in chronic fatigue syndrome: a shifting immune baseline<ref name="Russell, 2016" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785654/ (Full Text)] | *2016, Illness progression in chronic fatigue syndrome: a shifting immune baseline<ref name="Russell, 2016" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785654/ (Full Text)] | ||
*2017, Neural Consequences of [[Post-exertional malaise|Post-Exertion Malaise]] in [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]]<ref name="Cook, 2017" /> [http://www.sciencedirect.com/science/article/pii/S088915911730051X (Full Text)] | *2017, Neural Consequences of [[Post-exertional malaise|Post-Exertion Malaise]] in [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]]<ref name="Cook, 2017" /> [http://www.sciencedirect.com/science/article/pii/S088915911730051X (Full Text)] | ||
*2018, High-fidelity discrete modeling of the [[HPA axis]]: a study of regulatory plasticity in biology<ref>{{Cite journal|last=Sedghamiz|first=Hooman|last2=Morris|first2=Matthew| | *2018, High-fidelity discrete modeling of the [[HPA axis]]: a study of regulatory plasticity in biology<ref>{{Cite journal | last = Sedghamiz | first = Hooman | last2 = Morris | first2 = Matthew | authorlink2 = Matthew Morris | last3 = Craddock | first3 = Travis J.A. | authorlink3 =Travis Craddock | last4 = Whitley | first4 = Darrell | last5 = Broderick | first5 = Gordon | authorlink5 = Gordon Broderick | date = July 17, 2018 | title = High-fidelity discrete modeling of the HPA axis: a study of regulatory plasticity in biology| url = https://bmcsystbiol.biomedcentral.com/articles/10.1186/s12918-018-0599-1|journal=BMC Systems Biology|volume=12|issue=76 | pages = |doi=10.1186/s12918-018-0599-1|via=}}</ref> [https://bmcsystbiol.biomedcentral.com/articles/10.1186/s12918-018-0599-1 (Abstract)] | ||
*2019, Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome<ref>{{Cite journal|last=Morris|first=Matthew C.| | *2019, Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome<ref>{{Cite journal | last = Morris | first = Matthew C. | authorlink = Matthew Morris | last10 = Fletcher | first10 = Mary Ann | authorlink10 = Mary Ann Fletcher | last2 = Cooney | first2 = Katherine E. | authorlink2 = | last3 = Sedghamiz | first3 = Hooman | authorlink3 = | last4 = Abreu | first4 = Maria | authorlink4 = | last5 = Collado | first5 = Fanny | authorlink5 = | last6 = Balbin | first6 = Elizabeth G. | authorlink6 = Elizabeth Balbin | last7 = Craddock | first7 = Travis J.A. | authorlink7 = Travis Craddock | last8 = Klimas | first8 = Nancy G. | author-link8 = Nancy Klimas | last9 = Broderick | first9 = Gordon | author-link9 = Gordon Broderick | date = Mar 2019 | title = Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome| url = https://linkinghub.elsevier.com/retrieve/pii/S0149291819301122|journal=Clinical Therapeutics|language=en|volume=|issue= | pages = |doi=10.1016/j.clinthera.2019.03.002|quote=|via=}}</ref> [https://www.sciencedirect.com/science/article/abs/pii/S0149291819301122?via%3Dihub (Abstract)] | ||
*2019, From [[Diagnostic biomarker|biomarkers]] to targeted treatment: The myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and gulf war illness (GWI) story<ref>{{Cite journal|last=Klimas|first=N.G.| | *2019, From [[Diagnostic biomarker|biomarkers]] to targeted treatment: The myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and gulf war illness (GWI) story<ref>{{Cite journal | last = Klimas | first = N.G. | authorlink = Nancy Klimas | last2 = Fletcher | first2 = M.A. | authorlink2 = Mary Ann Fletcher | last3 = Abreu | first3 = M.M. | authorlink3 = | last4 = Aenlle | first4 = K. | authorlink4 = | last5 = Craddock | first5 = T. | authorlink5 = Travis Craddock | last6 = Broderick | first6 = G. | authorlink6 = Gordon Broderick | date = Feb 2019 | title = From biomarkers to targeted treatment: The myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and gulf war illness (GWI) story| url = https://linkinghub.elsevier.com/retrieve/pii/S0889159118311413|journal=Brain, Behavior, and Immunity|language=en|volume=76|issue=| pages = e40|doi=10.1016/j.bbi.2018.11.301|quote=|via=}}</ref> [https://www.sciencedirect.com/science/article/pii/S0889159118311413?via%3Dihub (Abstract)] | ||
*2019, Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary<ref>{{Cite journal|last=Richman|first=Spencer| | *2019, Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary<ref>{{Cite journal | last = Richman | first = Spencer | authorlink = | last2 = Morris | first2 = Matthew C. | authorlink2 = Matthew Morris | last3 = Broderick | first3 = Gordon | authorlink3 = Gordon Broderick | last4 = Craddock | first4 = Travis J.A. | authorlink4 = Travis Craddock | last5 = Klimas | first5 = Nancy G. | authorlink5 = Nancy Klimas | last6 = Fletcher | first6 = Mary Ann | date = Mar 2019 | title = Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary| url = https://linkinghub.elsevier.com/retrieve/pii/S0149291819300712|journal=Clinical Therapeutics|language=en|volume=|issue= | pages = |doi=10.1016/j.clinthera.2019.02.011|quote=|via= | authorlink6 = Mary Ann Fletcher}}</ref> [[pubmed:30871727|(Abstract)]] | ||
*2019, Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of [[Gene expression|Gene-expression]] Modules<ref>{{Cite journal|last=Jeffrey|first=Mary G.| | *2019, Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of [[Gene expression|Gene-expression]] Modules<ref>{{Cite journal | last = Jeffrey | first = Mary G. | authorlink = | last2 = Nathanson | first2 = Lubov | authorlink2 = Lubov Nathanson | last3 = Aenlle | first3 = Kristina | authorlink3 = | last4 = Barnes | first4 = Zachary M. | authorlink4 = Zachary Barnes | last5 = Baig | first5 = Mirza | authorlink5 = | last6 = Broderick | first6 = Gordon | authorlink6 = Gordon Broderick | last7 = Klimas | first7 = Nancy G. | authorlink7 = Nancy Klimas | last8 = Fletcher | first8 = Mary Ann | author-link8 = Mary Ann Fletcher | last9 = Craddock | first9 = Travis J.A. | author-link9 = Travis Craddock | date = Mar 2019 | title = Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of Gene-expression Modules| url = https://linkinghub.elsevier.com/retrieve/pii/S0149291819300475|journal=Clinical Therapeutics|language=en|volume=|issue= | pages = |doi=10.1016/j.clinthera.2019.01.011|quote=|via=}}</ref> - [[pubmed:30851951|(Abstract)]] | ||
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==References== | ==References== | ||
<references> | <references> | ||
<ref name="Aspler, 2008">{{Citation | <ref name="Aspler, 2008">{{Citation | last1 = Aspler | first1 = AL | last2 = Bolshin | first2 = C | last3 = Vernon | first3 = SD | authorlink3 = Suzanne Vernon | last4 = Broderick | first4 = G | authorlink4 = Gordon Broderick | title = Evidence of inflammatory immune signaling in chronic fatigue syndrome: A pilot study of gene expression in peripheral blood | journal = Behavioral and Brain Functions | volume = 4 | issue = 44 | page = | date = 2008 | doi = 10.1186/1744-9081-4-44 }}</ref> | ||
| last1 | <ref name="Broderick, 2010">{{Citation | last1 = Broderick | first1 = Gordon | authorlink1 = Gordon Broderick | last2 = Fuite | first2 = Jim | author-link2 = | last3 = Kreitz | first3 = Andrea | authorlink3 = | last4 = Vernon | first4 = Suzanne | authorlink4 = Suzanne Vernon | last5 = Klimas | first5 = Nancy | authorlink5 = Nancy Klimas | last6 = Fletcher | first6 = Mary Ann | authorlink6 = Mary Ann Fletcher | title = A Formal Analysis of Cytokine Networks in Chronic Fatigue Syndrome | journal = Brain, Behavior, and Immunity | volume = 24 | issue = 7 | page = 1209–1217 | date = 2010 | doi = 10.1016/j.bbi.2010.04.012 }}</ref> | ||
| last2 | <ref name="Broderick, 2012">{{Citation | last1 = Broderick | first1 = Gordon | authorlink1 = Gordon Broderick | last2 = Katz | first2 = Ben Z | authorlink2 = Ben Katz | last3 = Fernandes | first3 = Henrique | authorlink3 = | last4 = Fletcher | first4 = Mary Ann | authorlink4 = Mary Ann Fletcher | last5 = Klimas | first5 = Nancy | authorlink5 = Nancy Klimas | last6 = Smith | first6 = Frederick A | authorlink6 = | last7 = O'Gorman | first7 = Maurice RG | authorlink7 = | last8 = Vernon | first8 = Suzanne D | author-link8 = Suzanne Vernon | last9 = Taylor | first9 = Renee | author-link9 = Renee Taylor | title = Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue | journal = Journal of Translational Medicine | volume = 10 | issue = 191 | page = | date = 2012 | doi = 10.1186/1479-5876-10-191 }}</ref> | ||
| last3 | <ref name="Cook, 2017">{{Citation | last1 = Cook | first1 = Dane B. | authorlink1 = Dane Cook | last2 = Light | first2 = Alan R. | authorlink2 = Alan Light | last3 = Light | first3 = Kathleen C. | authorlink3 = Kathleen Light | last4 = Broderick | first4 = Gordon | authorlink4 = Gordon Broderick | last5 = Shields | first5 = Morgan R. | authorlink5 = | last6 = Dougherty | first6 = Ryan J. | authorlink6 = | last7 = Meyer | first7 = JacobD. | authorlink7 = | last8 = VanRiper | first8 = Stephanie| author-link8 = | last9 = Stegner | first9 = Aaron J. | author-link9 = | last10 = Ellingson | first10 = LauraD. | authorlink10 = | last11 = Vernon | first11 = SuzanneD. | authorlink11 = Suzanne Vernon | title = Neural Consequences of Post-Exertion Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | journal = Brain, Behavior, and Immunity | volume = | issue = | page = | date = 2017 | pmid = | doi = 10.1016/j.bbi.2017.02.009 }}</ref> | ||
| last4 | <ref name="Fuite, 2010">{{Citation | last1 = Fuite | first1 = Jim | authorlink1 = | last2 = Vernon | first2 = Suzanne | authorlink2 = Suzanne Vernon | last3 = Broderick | first3 = Gordon | authorlink3 = Gordon Broderick | title = Neuroendocrine and immune network re-modeling in chronic fatigue syndrome: an exploratory analysis. | journal = Genomics | volume = 92 | issue = 6 | page = 393-9 | date = 2008 | doi = 10.1016/j.ygeno.2008.08.008 }}</ref> | ||
| title | <ref name="Klimas, 2012">{{Citation | last1 = Klimas | first1 = NG | authorlink1 = Nancy Klimas | last2 = Broderick | first2 = G | authorlink2 = Gordon Broderick | last3 = Fletcher | first3 = MA | authorlink3 = Mary Ann Fletcher | title = Biomarkers for chronic fatigue. | journal = Brain Behav Immun | volume = 26 | issue = 8 | page = 1202-10 | date = 2012 | pmid = 22732129 | doi = 10.1016/j.bbi.2012.06.006 }}</ref> | ||
| journal = Behavioral and Brain Functions | <ref name="Nakamura, 2010">{{Citation | last1 = Nakamura | first1 = T | authorlink1 = | last2 = Schwander | first2 = S | authorlink2 = | last3 = Donnelly | first3 = R | authorlink3 = | last4 = Ortega | first4 = F | authorlink4 = | last5 = Togo | first5 = F | authorlink5 = | last6 = Broderick | first6 = G | authorlink6 = Gordon Broderick | last7 = Yamamoto | first7 = Y | authorlink7 = | last8 = Cherniack | first8 = NS | author-link8 = | last9 = Rapoport | first9 = D | author-link9 = | last10 = Natelson | first10 = BH | authorlink10 = Benjamin Natelson | title = Cytokines across the Night in Chronic Fatigue Syndrome with and without Fibromyalgia | journal = Clinical and Vaccine Immunology | volume = 17 | issue = 4 | page = 582–587 | date = 2010 | pmid = | doi = 10.1128/CVI.00379-09 }}</ref> | ||
| date | <ref name="Russell, 2016">{{Citation | last1 = Russell | first1 = Lindsey | authorlink1 = | last2 = Broderick | first2 = Gordon | authorlink2 = Gordon Broderick | last3 = Taylor | first3 = Renee | authorlink3 = Renee Taylor | last4 = Fernandes | first4 = Henrique | authorlink4 = | last5 = Harvey | first5 = Jeanna| authorlink5 = | last6 = Barnes | first6 = Zachary | authorlink6 = Zachary Barnes | last7 = Smylie | first7 = AnneLiese | authorlink7 = | last8 = Collado | first8 = Fanny | author-link8 = | last9 = Balbin | first9 = Elizabeth G. | author-link9 = | last10 = Katz | first10 = Ben Z. | authorlink10 = Ben Katz | last11 = Klimas | first11 = Nancy| authorlink11 = Nancy Klimas | last12 = Fletcher | first12 = Mary Ann | authorlink12 = Mary Ann Fletcher | title = Illness progression in chronic fatigue syndrome: a shifting immune baseline | journal = BMC Immunology | volume = 17 | issue = 3 | page = | date = 2016 | doi = 10.1186/s12865-016-0142-3 }}</ref> | ||
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[[Category:Researchers]] | [[Category:Researchers]] |
Latest revision as of 19:50, April 2, 2023
Gordon Broderick, PhD, is an associate professor at the University of Alberta, as well as part of Dr. Nancy Klimas’ Institute for Neuro Immune Medicine at Nova Southeastern University (NSU). He regularly serves on National Institutes of Health (NIH) study sections for chronic fatigue syndrome research.[1]
Education[edit | edit source]
- Undergarduate - Mechanical Engineering from McGill University
- Masters - Chemical Engineering from McGill University
- Doctorate - Chemical Engineering from the University of Montreal
- Post-doctorate - McGill’s School of Computer Science in cancer genomics
- Research fellowship - Computational Biochemistry at the University of Alberta[2]
International Consensus Criteria[edit | edit source]
Dr Broderick participated in the team that authored the 2011 case definition, International Consensus Criteria (ICC).[3]
Open Letter to The Lancet[edit | edit source]
Two open letters to the editor of The Lancet urged the editor to commission a fully independent review of the PACE trial, which the journal had published in 2011. In 2016, Dr. Broderick, along with 41 colleagues in the ME/CFS field, signed the second letter.
- 10 February 2016, An open letter to The Lancet, again - Virology blog[4]
Notable studies in ME/CFS[edit | edit source]
- 2008, Evidence of inflammatory immune signaling in chronic fatigue syndrome: A pilot study of gene expression in peripheral blood.[5] (Abstract)
- 2008, Neuroendocrine and immune network remodeling in chronic fatigue syndrome: an exploratory analysis[6] (Full Text)
- 2010, Biomarkers in Chronic Fatigue Syndrome: Evaluation of Natural Killer Cell Function and Dipeptidyl Peptidase IV/CD26[7] - (Full Text)
- 2010, A Formal Analysis of Cytokine Networks in Chronic Fatigue Syndrome[8]
- 2010, Cytokines across the night in chronic fatigue syndrome with and without fibromyalgia[9] (Full Text)
- 2010, Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome[10] - (Full Text)
- 2011, Myalgic encephalomyelitis: International Consensus Criteria[11]
- 2012, Biomarkers for chronic fatigue.[12] (Full Text)
- 2012, Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue[13] (Full Text)
- 2014, A Role for Homeostatic Drive in the Perpetuation of Complex Chronic Illness: Gulf War Illness and Chronic Fatigue Syndrome[14] (Full Text)
- 2015, Using gene expression signatures to identify novel treatment strategies in gulf war illness[15] - (Full text)
- 2016, Tracking post-infectious fatigue in clinic using routine Lab tests[16] (Full Text)
- 2016, Illness progression in chronic fatigue syndrome: a shifting immune baseline[17] (Full Text)
- 2017, Neural Consequences of Post-Exertion Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[18] (Full Text)
- 2018, High-fidelity discrete modeling of the HPA axis: a study of regulatory plasticity in biology[19] (Abstract)
- 2019, Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome[20] (Abstract)
- 2019, From biomarkers to targeted treatment: The myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and gulf war illness (GWI) story[21] (Abstract)
- 2019, Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary[22] (Abstract)
- 2019, Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of Gene-expression Modules[23] - (Abstract)
Talks and interviews[edit | edit source]
- 2009, Gordon Broderick on ME/CFS: the PANDORA Interview (Phoenix Rising)
- 2014, Models Suggesting Chronic Fatigue Syndrome Is “Amenable to Intervention” Provide Hope: Dr. Broderick Talks (Health Rising)
- 2015, Modelling Exercise Dynamics to Restore Immune Signaling in ME/CFS (Institute for Neuro Immune Medicine)
Online presence[edit | edit source]
- PubMed
- ResearchGate
- Profile page for the Institute for Neuro Immune Medicine]
- Gordon Broderick, Ph.D. - University of Alberta
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- ↑ Gordon Broderick, Ph.D. - University of Alberta
- ↑ "NOVA bio".
- ↑ Carruthers, Bruce M.; van de Sande, Marjorie I.; De Meirleir, Kenny L.; Klimas, Nancy G.; Broderick, Gordon; Mitchell, Terry; Staines, Donald; Powles, A.C. Peter; Speight, Nigel; Vallings, Rosamund; Bateman, Lucinda; Baumgarten-Austrheim, Barbara; Bell, David; Carlo-Stella, Nicoletta; Chia, John; Darragh, Austin; Jo, Daehyun; Lewis, Donald; Light, Alan; Marshall-Gradisnik, Sonya; Mena, Ismael; Mikovits, Judy; Miwa, Kunihisa; Murovska, Modra; Pall, Martin; Stevens, Staci (August 22, 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327–338. doi:10.1111/j.1365-2796.2011.02428.x. ISSN 0954-6820. PMC 3427890. PMID 21777306.
- ↑ Tuller, Date (February 10, 2016). "An open letter to The Lancet, again". Virology blog. Retrieved August 14, 2018.
- ↑ Aspler, AL; Bolshin, C; Vernon, SD; Broderick, G (2008), "Evidence of inflammatory immune signaling in chronic fatigue syndrome: A pilot study of gene expression in peripheral blood", Behavioral and Brain Functions, 4 (44), doi:10.1186/1744-9081-4-44
- ↑ Fuite, Jim; Vernon, Suzanne; Broderick, Gordon (2008), "Neuroendocrine and immune network re-modeling in chronic fatigue syndrome: an exploratory analysis.", Genomics, 92 (6): 393-9, doi:10.1016/j.ygeno.2008.08.008
- ↑ Fletcher, Mary A.; Zeng, Xiao R.; Maher, Kevin; Levis, Silvina; Hurwitz, Barry; Antoni, Michael; Broderick, Gordon; Klimas, Nancy G. (May 25, 2010). Unutmaz, Derya (ed.). "Biomarkers in Chronic Fatigue Syndrome: Evaluation of Natural Killer Cell Function and Dipeptidyl Peptidase IV/CD26". PLoS ONE. 5 (5): e10817. doi:10.1371/journal.pone.0010817. ISSN 1932-6203. PMC 2876037. PMID 20520837.
- ↑ Broderick, Gordon; Fuite, Jim; Kreitz, Andrea; Vernon, Suzanne; Klimas, Nancy; Fletcher, Mary Ann (2010), "A Formal Analysis of Cytokine Networks in Chronic Fatigue Syndrome", Brain, Behavior, and Immunity, 24 (7): 1209–1217, doi:10.1016/j.bbi.2010.04.012
- ↑ Nakamura, T; Schwander, S; Donnelly, R; Ortega, F; Togo, F; Broderick, G; Yamamoto, Y; Cherniack, NS; Rapoport, D; Natelson, BH (2010), "Cytokines across the Night in Chronic Fatigue Syndrome with and without Fibromyalgia", Clinical and Vaccine Immunology, 17 (4): 582–587, doi:10.1128/CVI.00379-09
- ↑ Fletcher, Mary Ann; Rosenthal, Martin; Antoni, Michael; Ironson, Gail; Zeng, Xiao R; Barnes, Zachary; Harvey, Jeanna M; Hurwitz, Barry; Levis, Silvina; Broderick, Gordon; Klimas, Nancy G (2010), "Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome", Behavioral and Brain Functions, 6 (76), doi:10.1186/1744-9081-6-76
- ↑ Carruthers, Bruce M.; van de Sande, Marjorie I.; De Meirleir, Kenny L.; Klimas, Nancy G.; Broderick, Gordon; Mitchell, Terry; Staines, Donald; Powles, A.C. Peter; Speight, Nigel; Vallings, Rosamund; Bateman, Lucinda; Baumgarten-Austrheim, Barbara; Bell, David; Carlo-Stella, Nicoletta; Chia, John; Darragh, Austin; Jo, Daehyun; Lewis, Donald; Light, Alan; Marshall-Gradisnik, Sonya; Mena, Ismael; Mikovits, Judy; Miwa, Kunihisa; Murovska, Modra; Pall, Martin; Stevens, Staci (August 22, 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327–338. doi:10.1111/j.1365-2796.2011.02428.x. ISSN 0954-6820. PMC 3427890. PMID 21777306.
- ↑ Klimas, NG; Broderick, G; Fletcher, MA (2012), "Biomarkers for chronic fatigue.", Brain Behav Immun, 26 (8): 1202-10, doi:10.1016/j.bbi.2012.06.006, PMID 22732129
- ↑ Broderick, Gordon; Katz, Ben Z; Fernandes, Henrique; Fletcher, Mary Ann; Klimas, Nancy; Smith, Frederick A; O'Gorman, Maurice RG; Vernon, Suzanne D; Taylor, Renee (2012), "Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue", Journal of Translational Medicine, 10 (191), doi:10.1186/1479-5876-10-191
- ↑ Craddock, Travis J.A.; Fritsch, Paul; Rice, Jr, Mark A.; del Rosario, Ryan M.; Miller, Diane B.; Fletcher, Mary Ann; Klimas, Nancy G.; Broderick, Gordon (2014), "A Role for Homeostatic Drive in the Perpetuation of Complex Chronic Illness: Gulf War Illness and Chronic Fatigue Syndrome", PLOS One, 9 (1): e84839, doi:10.1371/journal.pone.0084839
- ↑ Craddock, Travis J.A.; Harvey, Jeanna M.; Nathanson, Lubov; Barnes, Zachary M.; Klimas, Nancy G.; Fletcher, Mary Ann; Broderick, Gordon (July 9, 2015). "Using gene expression signatures to identify novel treatment strategies in gulf war illness". BMC Medical Genomics. 8. doi:10.1186/s12920-015-0111-3. ISSN 1755-8794. PMC 4495687. PMID 26156520.
- ↑ Harvey, Jeanna M.; Broderick, Gordon; Bowie, Alanna; Barnes, Zachary M.; Katz, Ben Z.; O'Gorman, Maurice R.G.; Vernon, SuzanneD.; Fletcher, Mary Ann; Klimas, Nancy G. (April 26, 2016). "Tracking post-infectious fatigue in clinic using routine Lab tests". BMC Pediatrics. 15: 54. doi:10.1186/s12887-016-0596-8. ISSN 1471-2431. PMC 4847210. PMID 27118537.
- ↑ Russell, Lindsey; Broderick, Gordon; Taylor, Renee; Fernandes, Henrique; Harvey, Jeanna; Barnes, Zachary; Smylie, AnneLiese; Collado, Fanny; Balbin, Elizabeth G.; Katz, Ben Z.; Klimas, Nancy; Fletcher, Mary Ann (2016), "Illness progression in chronic fatigue syndrome: a shifting immune baseline", BMC Immunology, 17 (3), doi:10.1186/s12865-016-0142-3
- ↑ Cook, Dane B.; Light, Alan R.; Light, Kathleen C.; Broderick, Gordon; Shields, Morgan R.; Dougherty, Ryan J.; Meyer, JacobD.; VanRiper, Stephanie; Stegner, Aaron J.; Ellingson, LauraD.; Vernon, SuzanneD. (2017), "Neural Consequences of Post-Exertion Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome", Brain, Behavior, and Immunity, doi:10.1016/j.bbi.2017.02.009
- ↑ Sedghamiz, Hooman; Morris, Matthew; Craddock, Travis J.A.; Whitley, Darrell; Broderick, Gordon (July 17, 2018). "High-fidelity discrete modeling of the HPA axis: a study of regulatory plasticity in biology". BMC Systems Biology. 12 (76). doi:10.1186/s12918-018-0599-1.
- ↑ Morris, Matthew C.; Cooney, Katherine E.; Sedghamiz, Hooman; Abreu, Maria; Collado, Fanny; Balbin, Elizabeth G.; Craddock, Travis J.A.; Klimas, Nancy G.; Broderick, Gordon; Fletcher, Mary Ann (March 2019). "Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome". Clinical Therapeutics. doi:10.1016/j.clinthera.2019.03.002.
- ↑ Klimas, N.G.; Fletcher, M.A.; Abreu, M.M.; Aenlle, K.; Craddock, T.; Broderick, G. (February 2019). "From biomarkers to targeted treatment: The myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and gulf war illness (GWI) story". Brain, Behavior, and Immunity. 76: e40. doi:10.1016/j.bbi.2018.11.301.
- ↑ Richman, Spencer; Morris, Matthew C.; Broderick, Gordon; Craddock, Travis J.A.; Klimas, Nancy G.; Fletcher, Mary Ann (March 2019). "Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary". Clinical Therapeutics. doi:10.1016/j.clinthera.2019.02.011.
- ↑ Jeffrey, Mary G.; Nathanson, Lubov; Aenlle, Kristina; Barnes, Zachary M.; Baig, Mirza; Broderick, Gordon; Klimas, Nancy G.; Fletcher, Mary Ann; Craddock, Travis J.A. (March 2019). "Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of Gene-expression Modules". Clinical Therapeutics. doi:10.1016/j.clinthera.2019.01.011.