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Genetics of chronic fatigue syndrome
(section)
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=== ME/CFS Gene Study === The [[ME/CFS Gene Study]] is still collecting data, but the initial pilot study by Perez et al. (2019) found 10 relatively common genes or gene variants were significantly more common in people with ME/CFS.<ref name="Nathanson2019" /> These were [[Cytochrome P450 2D6|CYP2D6]], [[Proline-rich transmembrane protein 4|PRRT4]], [[Serine Protease 56|PRSS56]], [[Armadillo Like Helical Domain Containing 4|C14orf37]], [[Ankyrin Repeat And Death Domain Containing 1B|ANKDD1B]], [[G protein-coupled bile acid receptor 1|GPBAR1]], [[Luteinizing hormone subunit beta|LHB]], [[ADAM metallopeptidase with thrombospondin type 1 motif 19|ADAMTS19]], [[Valyl-tRNA synthetase 2, mitochondrial|VARS2]], and [[Complexin 2|CPLX2]].<ref name="Nathanson2019" /> In 2021 the pilot was reviewed and found to have had serious methodological flaws that rendered its findings incorrect and conclusions spurious.<ref>{{Cite journal | title = Re-analysis of Genetic Risks for Chronic Fatigue Syndrome From 23andMe Data Finds Few Remain | date = 2021-03-18 | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012483/|journal=Frontiers in Pediatrics|volume=9|pages=590040 | last =Bedford | first =Felice L. | last2=Greshake Tzovaras | first2 = Bastian|doi=10.3389/fped.2021.590040|pmc=8012483|pmid=33816394|issn=2296-2360}}</ref> It is not clear how a study with such obvious and serious problems might even have passed peer review.
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