GETSET trial
The GETSET trial (short for Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome) was a trial investigating the effectiveness of "guided graded exercise self-help" in patients with CFS/ME. The protocol was published in June 2016.[1] The results were published in June 2017.[2]
Researchers[edit | edit source]
Lead Author Lucy Clark, Peter White, Francesca Pesola, Janice M Thomas, Mario Vergara-Williamson and Michelle Beynon
Funding[edit | edit source]
The trial was funded in full by the National Institute for Health Research's Research for Patient Benefit programme.[3]
Protocol[edit | edit source]
The protocol of the trial was published in JMIR Research Protocols in June 2016.[1]
Publication[edit | edit source]
The results were published on 22 June 2017 in the Lancet: Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial[4]
Commentary was provided by Daniel Clauw in the Lancet: Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome.[5]
The Science Media Centre provided: Expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS).[6]
It was reported in the Telegraph as Exercise can help chronic fatigue syndrome, study shows and other media outlets: Defeating chronic fatigue thanks to guided self-help approach to exercise.[7]
Criticism[edit | edit source]
Dr David Tuller has criticized the trial Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet.
Spoonseekerdotcom has criticised the GETSET trial.[8][9] [10]
Professor Jonathan Edwards criticised the study for its "incompetent level of science".[11]
The ME Association has also criticised the trial ME Association Review: GETSET fails to demonstrate GET can significantly improve physical function.
Additional criticism has been published by other patients [12] [13].
Documents[edit | edit source]
- Lead author Lucy Clark had previously published a booklet called Graded Exercise Therapy - A self-help guide for those with chronic fatigue syndrome/myalgic encephalomyelitis. This booklet was apparently distributed to patients in the GETSET trial.
See also[edit | edit source]
References[edit | edit source]
- ↑ 1.0 1.1 Clark, Lucy V.; McCrone, Paul; Ridge, Damien; Cheshire, Anna; Vergara-Williamson, Mario; Pesola, Francesca; White, Peter D. (June 8, 2016), "Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome (GETSET): Protocol for a Randomized Controlled Trial and Interview Study", JMIR research protocols, 5 (2): 70, doi:10.2196/resprot.5395, PMC 4917732, PMID 27278762
- ↑ Clark, Lucy V.; Pesola, Francesca; Thomas, Janice; Vergara-Williamson, Mario; Beynon, Michelle; White, Peter D. (June 22, 2017), "Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial", The Lancet, doi:10.1016/S0140-6736(16)32589-2
- ↑ "ISRCTN - ISRCTN22975026: Graded Exercise Therapy guided SElf-help Treatment for CFS/ME". www.isrctn.com. Retrieved January 26, 2020.
- ↑ Clark, Lucy V.; Pesola, Francesca; Thomas, Janice M.; Vergara-Williamson, Mario; Beynon, Michelle; White, Peter D. (July 22, 2017). "Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial". The Lancet. 390 (10092): 363–373. doi:10.1016/S0140-6736(16)32589-2. ISSN 0140-6736. PMID 28648402.
- ↑ Clauw, Daniel J (July 2017). "Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome". The Lancet. 390 (10092): 335–336. doi:10.1016/S0140-6736(17)30577-9.
- ↑ "expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS) | Science Media Centre". Retrieved May 8, 2020.
- ↑ "Defeating chronic fatigue thanks to guided self-help approach to exercise". Emergency Live. Retrieved May 8, 2020.
- ↑ Spoonseeker, Author (May 23, 2016). "A Few Notes on GETSET". spoonseekerdotcom. Retrieved January 26, 2020.
- ↑ Spoonseeker, Author (June 29, 2017). "Do GET Yourself". spoonseekerdotcom. Retrieved January 26, 2020.
- ↑ Spoonseeker, Author (July 3, 2017). "Spotlight on GETSET Julie". spoonseekerdotcom. Retrieved January 26, 2020.
- ↑ "Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet". Phoenix Rising ME / CFS Forums. Retrieved January 26, 2020.
- ↑ Corsius, Lou (June 23, 2017). "Yet another publication with misleading conclusions from PACE-land". it's about ME (in Nederlands). Retrieved January 26, 2020.
- ↑ Johnson, Cort (June 26, 2017). "On Your Marks GETSET: Don't Go - Major Graded Exercise ME/CFS Trial Underwhelms (Again)". Health Rising. Retrieved January 26, 2020.