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Decreased CBF, disturbed local blood flow regulation and neurovascular coupling, central adrenergic hyperactivity, hypocapnia and increase in intracranial presssure seem to play a strong role in the pathophysiology of the neurological symptoms in ME/CFS (Fig. 1). They can well explain cognitive impairment, brain fog, headache, psychomotor slowing, ataxia and loss of coordination of movements, hypersensitivity, sleep disturbances and dysautonomia.
Decreased CBF, disturbed local blood flow regulation and neurovascular coupling, central adrenergic hyperactivity, hypocapnia and increase in intracranial presssure seem to play a strong role in the pathophysiology of the neurological symptoms in ME/CFS (Fig. 1). They can well explain cognitive impairment, brain fog, headache, psychomotor slowing, ataxia and loss of coordination of movements, hypersensitivity, sleep disturbances and dysautonomia.
==== Author: (or citation) ====
==== Author: (or citation) ====
Wirth, K.J., Scheibenbogen, C. & Paul, F. [https://doi.org/10.1186/s12967-021-03143-3 An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.] An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. J Transl Med 19, 471 (2021). https://doi.org/10.1186/s12967-021-03143-3<ref name="Wirth2021b">{{Cite journal|last=Wirth | first = Klaus J.|author-link=|last2=Scheibenbogen | first2 = Carmen|author-link2=Carmen Scheibenbogen|last3=Paul|first3=Friedemann|author-link3=|date=2021-11-22|title=An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|url=https://doi.org/10.1186/s12967-021-03143-3|journal=Journal of Translational Medicine|volume=19|issue=1|pages=471|doi=10.1186/s12967-021-03143-3|issn=1479-5876|pmc=PMC8607226|pmid=34809664|access-date=|quote=|via=}}</ref>
Wirth, K.J., Scheibenbogen, C. & Paul, F. [https://doi.org/10.1186/s12967-021-03143-3 An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.] An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. J Transl Med 19, 471 (2021). https://doi.org/10.1186/s12967-021-03143-3<ref name="Wirth2021b">{{Cite journal|last=Wirth | first = Klaus J.|author-link= | last2 = Scheibenbogen | first2 = Carmen|author-link2=Carmen Scheibenbogen|last3=Paul|first3=Friedemann|author-link3=|date=2021-11-22|title=An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|url=https://doi.org/10.1186/s12967-021-03143-3|journal=Journal of Translational Medicine|volume=19|issue=1|pages=471|doi=10.1186/s12967-021-03143-3|issn=1479-5876|pmc=PMC8607226|pmid=34809664|access-date=|quote=|via=}}</ref>


==== Source: (e.g. internet address) ====
==== Source: (e.g. internet address) ====

Revision as of 00:04, December 1, 2022

Summary[edit | edit source]

Title: (or description)[edit | edit source]

Key neurological pathomechanisms in ME/CFS are intracranial hypertension, impaired cerebral blood flow, Hyperventilation/hypocapnia, and adrenergic hyperactivity.

Decreased CBF, disturbed local blood flow regulation and neurovascular coupling, central adrenergic hyperactivity, hypocapnia and increase in intracranial presssure seem to play a strong role in the pathophysiology of the neurological symptoms in ME/CFS (Fig. 1). They can well explain cognitive impairment, brain fog, headache, psychomotor slowing, ataxia and loss of coordination of movements, hypersensitivity, sleep disturbances and dysautonomia.

Author: (or citation)[edit | edit source]

Wirth, K.J., Scheibenbogen, C. & Paul, F. An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. J Transl Med 19, 471 (2021). https://doi.org/10.1186/s12967-021-03143-3[1]

Source: (e.g. internet address)[edit | edit source]

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

https://doi.org/10.1186/s12967-021-03143-3

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current21:46, February 28, 2022Thumbnail for version as of 21:46, February 28, 2022450 × 382 (45 KB)Notjusttired (talk | contribs)==== Title: (or description) ==== Key neurological pathomechanisms in ME/CFS are intracranial hypertension, impaired cerebral blood flow, Hyperventilation/hypocapnia, and adrenergic hyperactivity. Decreased CBF, disturbed local blood flow re...

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