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Decreased CBF, disturbed local blood flow regulation and neurovascular coupling, central adrenergic hyperactivity, hypocapnia and increase in intracranial presssure seem to play a strong role in the pathophysiology of the neurological symptoms in ME/CFS (Fig. 1). They can well explain cognitive impairment, brain fog, headache, psychomotor slowing, ataxia and loss of coordination of movements, hypersensitivity, sleep disturbances and dysautonomia. | Decreased CBF, disturbed local blood flow regulation and neurovascular coupling, central adrenergic hyperactivity, hypocapnia and increase in intracranial presssure seem to play a strong role in the pathophysiology of the neurological symptoms in ME/CFS (Fig. 1). They can well explain cognitive impairment, brain fog, headache, psychomotor slowing, ataxia and loss of coordination of movements, hypersensitivity, sleep disturbances and dysautonomia. | ||
==== Author: (or citation) ==== | ==== Author: (or citation) ==== | ||
Wirth, K.J., Scheibenbogen, C. & Paul, F. [https://doi.org/10.1186/s12967-021-03143-3 An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.] An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. J Transl Med 19, 471 (2021). https://doi.org/10.1186/s12967-021-03143-3<ref name="Wirth2021b">{{Cite journal|last=Wirth | first = Klaus J.|author-link= | last2 = Scheibenbogen | first2 = Carmen|author-link2=Carmen Scheibenbogen|last3=Paul|first3=Friedemann|author-link3=|date=2021-11-22|title=An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|url=https://doi.org/10.1186/s12967-021-03143-3|journal=Journal of Translational Medicine|volume=19|issue=1|pages=471|doi=10.1186/s12967-021-03143-3|issn=1479-5876|pmc=PMC8607226|pmid=34809664|access-date=|quote=|via=}}</ref> | Wirth, K.J., Scheibenbogen, C. & Paul, F. [https://doi.org/10.1186/s12967-021-03143-3 An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.] An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. J Transl Med 19, 471 (2021). https://doi.org/10.1186/s12967-021-03143-3<ref name="Wirth2021b">{{Cite journal|last=Wirth | first = Klaus J. | author-link = | last2 = Scheibenbogen | first2 = Carmen | author-link2 = Carmen Scheibenbogen | last3 = Paul | first3 = Friedemann | author-link3 = | date = 2021-11-22 | title = An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|url=https://doi.org/10.1186/s12967-021-03143-3|journal=Journal of Translational Medicine|volume=19|issue=1|pages=471|doi=10.1186/s12967-021-03143-3|issn=1479-5876|pmc=PMC8607226|pmid=34809664|access-date=|quote=|via=}}</ref> | ||
==== Source: (e.g. internet address) ==== | ==== Source: (e.g. internet address) ==== |
Latest revision as of 11:39, April 3, 2023
Summary[edit | edit source]
Title: (or description)[edit | edit source]
Key neurological pathomechanisms in ME/CFS are intracranial hypertension, impaired cerebral blood flow, Hyperventilation/hypocapnia, and adrenergic hyperactivity.
Decreased CBF, disturbed local blood flow regulation and neurovascular coupling, central adrenergic hyperactivity, hypocapnia and increase in intracranial presssure seem to play a strong role in the pathophysiology of the neurological symptoms in ME/CFS (Fig. 1). They can well explain cognitive impairment, brain fog, headache, psychomotor slowing, ataxia and loss of coordination of movements, hypersensitivity, sleep disturbances and dysautonomia.
Author: (or citation)[edit | edit source]
Wirth, K.J., Scheibenbogen, C. & Paul, F. An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. J Transl Med 19, 471 (2021). https://doi.org/10.1186/s12967-021-03143-3[1]
Source: (e.g. internet address)[edit | edit source]
https://doi.org/10.1186/s12967-021-03143-3
Other information:[edit | edit source]
See also[edit | edit source]
References[edit | edit source]
- ↑ Wirth, Klaus J.; Scheibenbogen, Carmen; Paul, Friedemann (November 22, 2021). "An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Journal of Translational Medicine. 19 (1): 471. doi:10.1186/s12967-021-03143-3. ISSN 1479-5876. PMC 8607226. PMID 34809664.
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